Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapy

Abstract

TF-PEG-BSH is a potent BDS for BNCT not only in terms of delivering a high concentration of (10)B into tumor tissue, but also the selective delivery of (10)B into the tumor cells.

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

“…Transferrin liposomes have been reported to be able to deliver borocaptate (BSH) and small interfering RNA (siRNA) into the CNS, which is highly significant, because these compounds do not readily cross the BBB. 224,246,263 In the same way, the covalent binding of lactoferrin to the liposome surface proved to be an effective strategy for the treatment of brain tumors. 244 In glioma therapy, similarly to the BBB, the BBTB also represents a challenge for glioma-targeted delivery.…”

Enhancing effect of ultrasound on boron concentrations in an oral squamous cell carcinoma cell line SAS for boron neutron capture therapy

“…Active transport of BSH is not expected. Thus, modifications of BSH such as the use of anti-EGFR antibodyconjugated or transferrin-conjugated liposomes to transfer BSH into tumor cells specifically have been investigated [29][30][31].…”

The “fate” of polymeric and lipid nanoparticles for brain delivery and targeting: Strategies and mechanism of blood–brain barrier crossing and trafficking into the central nervous system

“…Glioma is unfortunately the most frequent primary CNS tumor in humans: the various types of gliomas can be identified by histological characteristics reflecting cellular differentiation lineages: astrocytomas, oligodendrogliomas and mixed oligoastrocytomas [94]. Glioma is highly infiltrative, leading to the complete disruption of normal tissue architecture and displays angiogenic features and high degree of vascular proliferation along with endothelial cell hyperplasia [95].…”