Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia

Ando, Ken; Suzuki, Yoshiyuki; Kaminuma, Takuya; Yoshimoto, Yuya; Oike, Takahiro; Okonogi, Noriyuki; Sato, Hiro; Tamaki, Tomoaki; Noda, Shin‐ei; Mimura, Kosaku; Nakano, Takashi

doi:10.1080/02656736.2018.1492027

Cited by 10 publications

(8 citation statements)

References 28 publications

(32 reference statements)

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“…Recently, several groups have reported the combined effects of local HT with ICI. Ando et al reported that the addition of C4 to local HT at 42.5 C for 60 min in a water bath did not significantly inhibit the growth of HT tumors compared with local HT monotherapy in EL-4 lymphoma-bearing mice [32]. Chao et al reported that magnetic HT at 50 C for 10 min with PD-L1 blockade and poly (lactic-co-glycolic) acid R837 nanoparticles induced both local and abscopal effects in back skin tumors in B16-bearing mice [33].…”

Section: Discussionmentioning

confidence: 99%

Local hyperthermia combined with CTLA-4 blockade induces both local and abscopal effects in a murine breast cancer model

Ibuki

Takahashi

Tamari

et al. 2021

International Journal of Hyperthermia

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Purpose: To evaluate the antitumor efficacy in local and distant tumors induced by local hyperthermia with CTLA-4 blockade Methods: A mouse breast cancer cell line was inoculated into both sides of the legs of mice. The mice were treated with three administrations of CTLA-4 blockade, a single application of local hyperthermia (42.5 C for 20 min) to the tumor on one side of the leg, or the combination of the two. Tumor growth in locally heated tumors (HT tumors) and unheated distant tumors (UnHT tumors) and overall survival were evaluated. Results: In the combination group, tumor volume significantly decreased for both HT and UnHT tumors compared with the tumors in the untreated and local hyperthermia monotherapy groups. Remarkable efficacy was only observed in the combination therapy group, in which 7 of 18 mice responded to HT and UnHT tumors, with significant prolonged overall survival. Conclusions: Combination therapy enhanced the antitumor response not only in HT tumors but also in UnHT tumors and prolonged overall survival.

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Section: Discussionmentioning

confidence: 99%

Local hyperthermia combined with CTLA-4 blockade induces both local and abscopal effects in a murine breast cancer model

Ibuki

Takahashi

Tamari

et al. 2021

International Journal of Hyperthermia

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“…The literature regarding heat and the immune system varies largely depending on the heating methods and treatment durations used; what is well known, however, is that controlled, localized heat can elicit a systemic anti-tumor immune response. [200][201][202][203] The evidence associated with this immune stimulation strongly suggests an induction of dendritic cell (DC) maturation and cross-presentation to CD8 + T cells, while other findings hint at a heightened cytotoxicity profile of NK cells. [200,204]…”

Section: Localized Heat and The Immune Systemmentioning

confidence: 99%

“…[212,213] DC can then home to the draining lymph node and cross-present tumor antigens to CD8 + T cells, enabling their effector function to expand and migrate to the tumor site and elicit a cytotoxic response. [201,214] Numerous in vivo studies have confirmed this adaptive immune response by treating tumor-bearing rodents with moderate hyperthermia and then re-challenging them with the same tumors at a later time to observe if a memory response exists. Some notable examples of this response are discussed next.…”

Section: Adaptive Immunitymentioning

confidence: 99%

The Effects of Localized Heat on the Hallmarks of Cancer

Hannon

Tansi

Hilger

et al. 2021

Advanced Therapeutics

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Heat has been used to treat tumors for thousands of years. There are reports of the Egyptians and Greek philosophers using such treatments as far back as 3000 BC and 500 BC respectively for various solid tumors. Albeit, in these cases, the treatment was not very controlled and consisted of hot sticks or blades placed against tissue in order to thermally ablate the tumor. It was not until recent times that the application of heat through various mediums enabled a more controlled, localized, and consistent method of treating tumors. While the therapeutic potential of this treatment has become more apparent, the mechanisms related to its efficacy are only recently beginning to surface. This review discusses the evidence associated with the effects of localized heat on the hallmarks of cancer. Key literature describing modulations to vasculature, cell viability, DNA damage and repair, metabolism, immune system, and tumor metastasis in response to heat will be reviewed along with considerations for its optimal implementation in the clinic to enhance the efficacy of conventional treatments.

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“…HT elicits innate and adaptive immune responses which may enhance its treatment effects [3,42,43]. Studies have found that HT may increase the cytotoxic activity of natural killer (NK) and CD8þ T cells against tumor cells [44,45]. Preclinical studies have demonstrated that immunotherapy following HT may enhance antitumor immune responses [46][47][48][49].…”

Section: Ht and Immunomodulationmentioning

confidence: 99%

Hyperthermia treatment advances for brain tumors

Skandalakis

Rivera

Rizea

et al. 2020

International Journal of Hyperthermia

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Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of new technologies, HT approaches are now important for the treatment of brain tumors. We review current clinical applications of HT in neuro-oncology and ongoing preclinical research aiming to advance HT approaches to clinical practice. Laser interstitial thermal therapy (LITT) is currently the most widely utilized thermal ablation approach in clinical practice mainly for the treatment of recurrent or deepseated tumors in the brain. Magnetic hyperthermia therapy (MHT), which relies on the use of magnetic nanoparticles (MNPs) and alternating magnetic fields (AMFs), is a new quite promising HT treatment approach for brain tumors. Initial MHT clinical studies in combination with fractionated radiation therapy (RT) in patients have been completed in Europe with encouraging results. Another combination treatment with HT that warrants further investigation is immunotherapy. HT approaches for brain tumors will continue to a play an important role in neuro-oncology.

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Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia

Abstract: CD8-positive T cell-mediated antitumor immunity significantly contributes to the antitumor effect of LH.

Cited by 10 publications

References 28 publications

Local hyperthermia combined with CTLA-4 blockade induces both local and abscopal effects in a murine breast cancer model

Local hyperthermia combined with CTLA-4 blockade induces both local and abscopal effects in a murine breast cancer model

The Effects of Localized Heat on the Hallmarks of Cancer

Hyperthermia treatment advances for brain tumors

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