Tumor size is of prognostic value in surgically treated FIGO stage II cervical cancer

Horn, Lars‐Christian; Fischer, Uta; Raptis, Georgios; Bilek, K; Hentschel, Bettina

doi:10.1016/j.ygyno.2007.06.026

Cited by 92 publications

(45 citation statements)

References 38 publications

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“…Horn et al reported that the lesion diameter >4 cm indicated a poor prognosis, and Plante et al reported that the lesion diameter >2 cm had a high risk of recurrence (Horn et al, 2007;Plante et al, 2011). In this study, subjects were divided into three groups based on the maximum diameter of tumors: <2 cm, 2-4 cm, 4 cm.…”

Section: Discussionmentioning

confidence: 90%

Clinical and Pathological Factors Related to the Prognosis of Chinese Patients with Stage Ⅰb To Ⅱb Cervical Cancer

Xie

Song²,

Cui³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 90%

Clinical and Pathological Factors Related to the Prognosis of Chinese Patients with Stage Ⅰb To Ⅱb Cervical Cancer

Xie

Song²,

Cui³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…The treatment approach of cervical cancer depends on the stage and tumour size, age of the patient and comorbidities (Balkin, 2007;Horn et al, 2007). Usually, the standard first line treatments used are radiation therapy (RT), surgery and adjuvant chemotherapy with RT (Balkin, 2007;Ferlay et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Survival Rates of Cervical Cancer Patients in Malaysia

Muhamad¹,

Kamaluddin²,

Adon³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the most common malignant cancer of the female reproductive organs worldwide. Currently, cervical cancer can be prevented by vaccination and detected at an early stage via various screening methods. Malaysia, as a developing country faces a heavy disease burden of cervical cancer as it is the second most common cancer among Malaysian women. This population based study was carried out to fulfil the primary aim of determining the survival rates of Malaysian women with cervical cancer and associated factors. Data were obtained from two different sources namely, the Malaysian National Cancer Registry (MNCR) and National Health Informatics Centre (NHIC) from 1st January 2000 to 31st December 2005. Kaplan Meier analyses were conducted to identify the overall survival rates and median survival time. Differences in survival among different ethnic and age group were compared using the log-rank test. A total of 5,859 patients were included. The median survival time for cervical cancer in this study was 65.8 months and the 5-year survival rate was 71.1% . The overall observed survival rates at 1, 3 and 5 years were 94.1%, 79.3% and 71.1% respectively. The log-rank test finding also showed that there were significant differences in the 5-year survival rate among different ethnic groups. Malays had the lowest survival rate of 59.2% followed by Indians (69.5%) and Chinese (73.8%). The overall 5-year survival rate among patients with cervical cancer in Malaysia is relatively good. Age and ethnic groups remain as significant determining factors for cervical cancer survival rate.

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“…and treatment related factors (5,(10)(11)(12). In this study clinical, histopathologic and socio-demographic factor were analyzed to assess their prognostic significance.…”

Section: Discussionmentioning

confidence: 99%

“…Many investigators have emphasized the importance of patient characteristics (age, and anemia), tumor (stage, size, lymph node, and grade) and treatment factors (treatment modality, irradiation technique, dose, and duration) and indicated influence on outcome (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological, but not socio-demographic factors affect the prognosis in cervical carcinoma

Munagala

Shesh²,

Ganesarajah³

et al. 2010

Oncol Rep

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Abstract. The purpose of this study was to investigate the prognostic factors, such as clinical, histological and sociodemographic features affecting the event-free and overall survival of the patients with stage I-III carcinoma of the cervix. Eighty-nine patients with International FIGO stage I-III cervical cancer were treated radiation therapy and follow-up of 5-7 years were analyzed for various clinical, histopathological and socio-demographic factors influencing prognosis. Survival estimations were performed using the Kaplan-Meier method, and were compared using the un-weighted log-rank test and multivariable analysis using the Cox proportional hazards model. The median age was 46 years (range, 28-65 years). The 5-year event-free survival (EFS) and overall survival (OAS), along with standard error (SE), were 65.2% (7.0%) and 81.4% (6.1%), respectively. Significant prognostic factors for EFS include, stage (P=0.019), pelvic lymph node metastasis (P=0.013), parametrial (PMT) involvement (P=0.025), number of parametria involved (P=0.000) and tumor size (P=0.034). However, number of parametrial invasion was only significant prognostic factors for overall survival (P=0.015); 5-year survival rate was significantly lower in patients with both PMT involved (58%) than with one PMT involved (>85%). Using a multivariable analysis, we found that number of PMT involved being the only independent significant factor for the development of recurrent disease. None of the socio-demographic factors analyzed were of prognostic importance on event-free and overall survival in cervical cancer patients. Several clinicopathological factors were of prognostic significance but none of the socio-demographic factors analyzed had any role in determining patient outcome. Hence, in cervical cancer, prognosis is more likely dependent on clinical than sociodemographic factors unlike several other cancers where their significant role is well documented. Study of clinical and demographic characteristics for their influence on patient survival could help design better patient management strategies.

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Tumor size is of prognostic value in surgically treated FIGO stage II cervical cancer

Cited by 92 publications

References 38 publications

Clinical and Pathological Factors Related to the Prognosis of Chinese Patients with Stage Ⅰb To Ⅱb Cervical Cancer

Clinical and Pathological Factors Related to the Prognosis of Chinese Patients with Stage Ⅰb To Ⅱb Cervical Cancer

Survival Rates of Cervical Cancer Patients in Malaysia

Clinicopathological, but not socio-demographic factors affect the prognosis in cervical carcinoma

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