Tumor size is an independent predictor of lymph node metastasis and survival in early stage endometrioid endometrial cancer

Abstract

TS was an independent predictor of lymph node metastasis and disease-specific survival in patients with EEC grossly confined to the uterus. Tumor >5 cm was a predictor of disease-specific survival but no difference in outcome was noted between tumor >2-5 cm and tumor ≤2 cm.

Is Tumor Size Really Important for Prediction of Lymphatic Dissemination in Grade 1 Endometrial Carcinoma With Superficial Myometrial Invasion?

“…Given these findings, the authors have concluded that it may be reasonable to defer LND in all grade 1 tumors with less than 50% MMI, irrespective of tumor size. 24 Our finding of 0% rate of LN involvement in this subgroup of patients may be attributed to the limited number of patients (n =120) in our study when compared with those of Mahdi et al 23 and Vargas et al 24 (ns =1914 and 3816, respectively). We showed that only 1 of 120 women in this subgroup had LVSI, whereas no information is available about LVSI in those studies that analyzed SEER data.…”

“…In a Surveillance, Epidemiology, and End Results (SEER) data analysis, Mahdi et al 23 23 The rate of LN involvement has been reported to be 1.46% (28/1914) in this subgroup of patients. However, no information was given about LVSI in that study.…”

“…However, no information was given about LVSI in that study. 23 Vargas et al 24 have reported approximately 19,329 women with surgically staged EEC using the SEER data. Of those, 14,934 fulfilled the current Mayo criteria for complete surgical staging (3816 women with FIGO grade 1, PTD 9 2 cm, and e50% MMI; 3860 women with FIGO grade 2, PTD 9 2 cm, and e50% MMI; 2591 women with FIGO grade 3 histology; and 4667 women with 950% MMI).…”

Identifiable Risk Factors for Lymph Node Metastases in Grade 1 Endometrial Carcinoma

“…With regards to this study, we identified that this relationship also stands for grade 1 carcinomas with less than 50% invasion of the myometrium. In a similar study, Mahdi et al 25 reported that tumors larger than 5 cm had a greater possibility to present with nodal disease in carcinomas of any grade and stage. These results are closer to the ones of our study in which the greatest relationship between tumor size and nodal diseaseValthough not totally statistically importantVwas when the comparison was made between tumors larger than 4 cm and tumors measuring 4 cm or smaller.…”

Risk Factors for Recurrence in Low-Risk Endometrial Cancer: A Case-Control Study

“…According to the Surveillance, Epidemiology and End Results (SEER) data, low-risk EC patients represent approximately 61% of endometrioid ECs grossly confined to the uterus [22,23]. Although the recurrence rate is very low in this subgroup of patients (1-7%), the absolute number of recurrences in low-risk EC seems to be actually considerable as approximately 70% of women with EC are given a diagnosis while the disease is confined to the uterus [24].…”