Tumor-Simulating Thoracic Extramedullary Hematopoiesis

Elbers, Hans R.J.; Stadt, J Van; Wagenaar, Sjoerd Sc.

doi:10.1016/s0003-4975(10)61735-3

Cited by 11 publications

(8 citation statements)

References 10 publications

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“…[1] Common settings in which extramedullary hematopoiesis can be seen include thalassemia, sickle cell disease, spherocytosis, and other hemoglobinopathies. [2] Chronic anemic conditions including pernicious anemia, vitamin B12 deficiency and Gaucher's disease predispose to extramedullary hematopoiesis.…”

Section: Discussionmentioning

confidence: 99%

“…[5] However, case reports have demonstrated this condition in patients without any apparent underlying blood disorder. [1]…”

Section: Discussionmentioning

confidence: 99%

“…[6] These intrathoracic tumors often localize between the 6 th and 12 th thoracic vertebrae. [1] They can present as unilateral, bilateral or as multiple masses in the paravertebral area, anterior mediastinum, pericardium and pleura. [34]…”

Section: Discussionmentioning

confidence: 99%

“…Extramedullary hematopoietic tissues are known to be radiosensitive and external beam radiation can effectively reduce mass size and associated symptoms. [1]…”

Section: Discussionmentioning

confidence: 99%

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Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

2007

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Extramedullary hematopoiesis is a rare cause of an intrathoracic mass in individuals with hemolytic disorders. It can be clinically confused with other tumors of the mediastinum. While radiologic studies often demonstrate findings suggesting intrathoracic extramedullary hematopoiesis, histology is usually required for diagnostic purposes. Thoracotomy was the mainstay procedure for obtaining tissue diagnosis and resection. However, video-assisted thoracoscopy (VATS) is an amendable and less-invasive means of tumor removal. We report a case of a posterior mediastinal extramedullary hematopoietic mass in a forty-two year old male in which VATS was utilized for diagnosis and resection.

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Section: Discussionmentioning

confidence: 99%

“…[5] However, case reports have demonstrated this condition in patients without any apparent underlying blood disorder. [1]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Extramedullary hematopoietic tissues are known to be radiosensitive and external beam radiation can effectively reduce mass size and associated symptoms. [1]…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

2007

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“…1 The intrathoracic area is another rare site of extramedullary erythropoiesis, where it occurs predominantly in the paravertebral area. 2,3 It is almost always accompanied by hemolytic anemia such as hereditary spherocytic anemia, pernicious anemia, or thalassemia and, in a few cases, blood disease is absent. Since intrathoracic extramedullary hematopoiesis was first noted clinically by Ash-Upmark in 1945, 4 about 40 cases have been reported in the world literature.…”

mentioning

confidence: 99%

Intrathoracic extramedullary hematopoiesis arising in marble bone disease

Shigemura

Akashi

Nakagiri

2002

Jpn J Thorac Caridovasc Surg

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We report a man with intrathoracic extramedullary hematopoiesis accompanied by marble bone disease who underwent thoracoscopic resection safely and definitively, followed by a radionuclide scan. Although intrathoracic extramedullary hematopoiesis is almost always accompanied by hemolytic anemia, this man's hematological data normalized. A consensus on the tumor genesis mechanism has yet to be reached, but the existence of marble bone disease in our case throws new light on the genetic mechanism in intrathoracic extramedullary hematopoiesis.

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Intrathoracic extramedullary hematopoietic tumor in hemoglobin H disease

Shih

Kuo

et al. 1992

American J Hematol

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We report a Chinese patient with hemoglobin H (Hb H) disease who developed intrathoracic extramedullary hematopoiesis (EMH) 17 years following splenectomy for a blunt abdominal injury. The patient initially presented with extreme hyperbilirubinemia and multiple intrathoracic tumors. Hb H disease was diagnosed after investigation, and the marked jaundice, which declined gradually after supportive treatment, was attributed to his chronic hemolysis superimposed on an acute hepatitis C virus infection. A biopsy of the intrathoracic tumors revealed an EMH. Intrathoracic EMH, which is usually encountered in patients with beta-thalassemia and hereditary spherocytosis, has never been reported in Hb H disease. In areas where thalassemia is prevalent, EMH should be considered in the differential diagnosis of patients who have chronic anemia with asymptomatic intrathoracic tumor to avoid unnecessary surgical interventions.

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Tumor-Simulating Thoracic Extramedullary Hematopoiesis

Cited by 11 publications

References 10 publications

Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

Video-assisted thoracoscopic surgery for intrathoracic extramedullary hematopoiesis

Intrathoracic extramedullary hematopoiesis arising in marble bone disease

Intrathoracic extramedullary hematopoietic tumor in hemoglobin H disease

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