Tumor seeding along the needle track after percutaneous lung biopsy

Valle, Leonardo Guedes Moreira; Rocha, Rafael Dahmer; Mendes, Guilherme Falleiros; Succi, José Ernesto; Andrade, Juliano Ribeiro de

doi:10.1590/s1806-37562016000000280

Cited by 7 publications

(5 citation statements)

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“…Tumor cell seeding after percutaneous needle biopsies can occur in various types of cancers [ 5 , 9 , 10 ]. In this study, we studied subcutaneously grown SKMEL2, a highly aggressive human melanoma xenograft, to test tumor seeding after core needle biopsy and the efficacy of GDS.…”

Section: Resultsmentioning

confidence: 99%

Prevention of tumor seeding during needle biopsy by chemotherapeutic-releasing gelatin sticks

et al. 2017

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Needle biopsy is an indispensable diagnostic tool in obtaining tumor tissue for diagnostic examination. Tumor cell seeding in the needle track during percutaneous needle biopsies has been reported for various types of cancers. The mechanical force of the biopsy both directly displaces the malignant cells and causes bleeding and fluid movement that can further disseminate cells. To prevent the risk of tumor cell seeding during biopsy, we developed a gelatin stick loaded with chemotherapeutics such as doxorubicin (DXR) that was inserted into the biopsy canal. The gelatin-doxorubicin sticks (GDSs) were created by passively loading precut gelatin foam strips (Gelfoam) with doxorubicin solution. The dried GDSs were inserted into the needle track through the sheath during the needle biopsy and eventually self-absorbed. We showed that this procedure prevented iatrogenic tumor seeding during needle biopsies in two subcutaneous tumor models. In an alternative application, using GDSs in intracranial brain tumor implantation avoided the outgrowth of tumor from the rodent brain, which could otherwise potentially fuse the tumor with the meninges and distort the results in therapeutic studies in rodent brain tumor models.

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Section: Resultsmentioning

confidence: 99%

Prevention of tumor seeding during needle biopsy by chemotherapeutic-releasing gelatin sticks

et al. 2017

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“…A comprehensive review of the literature reveals that the observed incidence of tumor seeding after biopsy of hepatocellular carcinoma ranges from 0.6% to 5.1% of cases [25]. Furthermore, there have been reports of lung cancer tumor seeding with chest wall implantation in several documented cases [26,27]. Therefore, tract seeding is not unique to renal mass biopsy, and prior experience is largely anecdotal, with few reported cases.…”

Section: Discussionmentioning

confidence: 99%

Safety and Diagnostic Efficacy of Image-Guided Biopsy of Small Renal Masses

Serhal,

Rangwani,

Seedial

et al. 2024

Cancers

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Introduction: Image-guided renal mass biopsy is gaining increased diagnostic acceptance, but there are limited data concerning the safety and diagnostic yield of biopsy for small renal masses (≤4 cm). This study evaluated the safety, diagnostic yield, and management after image-guided percutaneous biopsy for small renal masses. Methods: A retrospective IRB-approved study was conducted on patients who underwent renal mass biopsy for histopathologic diagnosis at a single center from 2015 to 2021. Patients with a prior history of malignancy or a renal mass >4 cm were excluded. Descriptive statistics were used to summarize patient demographics, tumor size, the imaging modality used for biopsy, procedure details, complications, pathological diagnosis, and post-biopsy management. A biopsy was considered successful when the specimen was sufficient for diagnosis without need for a repeat biopsy. Complications were graded according to the SIR classification of adverse events. A chi-squared test (significance level set at p ≤ 0.05) was used to compare the success rate of biopsies in different lesion size groups. Results: A total of 167 patients met the inclusion criteria. The median age was 65 years (range: 26–87) and 51% were male. The median renal mass size was 2.6 cm (range: one–four). Ultrasound was solely employed in 60% of procedures, CT in 33%, a combination of US/CT in 6%, and MRI in one case. With on-site cytopathology, the median number of specimens obtained per procedure was four (range: one–nine). The overall complication rate was 5%. Grade A complications were seen in 4% (n = 7), consisting of perinephric hematoma (n = 6) and retroperitoneal hematoma (n = 1). There was one grade B complication (0.5%; pain) and one grade D complication (0.5%; pyelonephritis). There was no patient mortality within 30 days post-biopsy. Biopsy was successful in 88% of cases. A sub-group analysis showed a success rate of 85% in tumors <3 cm and 93% in tumors ≥3 cm (p = 0.01). Pathological diagnoses included renal cell carcinoma (65%), oncocytoma (18%), clear cell papillary renal cell tumors (9%), angiomyolipoma (4%), xanthogranulomatous pyelonephritis (1%), lymphoma (1%), high-grade papillary urothelial carcinoma (1%), and metanephric adenoma (1%), revealing benign diagnosis in 30% of cases. The most common treatment was surgery (40%), followed by percutaneous cryoablation (22%). In total, 37% of patients were managed conservatively, and one patient received chemotherapy. Conclusion: This study demonstrates the safety and diagnostic efficacy of image-guided biopsy of small renal masses. The diagnostic yield was significantly higher for masses 3–4 cm in size compared to those <3 cm. The biopsy results showed a high percentage of benign diagnoses and informed treatment decisions in most patients.

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“…The complication rate and diagnostic performance are the two main factors to consider when choosing a diagnostic procedure. Until now, several complications have been reported in patients underwent PNB, including pneumothorax, hemorrhage, tumor seeding, and air embolism . Pneumothorax and hemorrhage are the most two common complications, with reported frequencies of 17%‐26.6% and 4%‐27%, respectively .…”

Section: Discussionmentioning

confidence: 99%

Comparison of computed tomography‐guided percutaneous needle biopsy and endobronchial biopsy in the diagnosis of multifocal pulmonary lesions

Zheng

et al. 2019

Clinical Laboratory Analysis

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BackgroundThe retrospective study aimed to compare computed tomography (CT)‐guided percutaneous needle biopsy (PNB) and endobronchial biopsy (EB) in the diagnosis of multifocal pulmonary lesions with endobronchial involvement.MethodsBetween November 2014 and June 2017, consecutive patients who had underwent both CT‐guided PNB and EB via bronchoscopy for diagnosis of pulmonary lesions were evaluated retrospectively. Tissue samples were submitted for pathological examination, acid‐fast bacilli, TB RT‐PCR, and mycobacterial culture. Sensitivities of the two methods alone or in combination were calculated and compared using Fisher's exact test.ResultsSixty‐seven patients (46 men and 21 women) were enrolled and could be diagnosed (32 malignant, 18 TB, and 17 benign). A final diagnosis of either malignant or TB diseases was made in 34 (68.0%) patients for CT‐guided PNBs, 19 (38.0%) patients for EBs, and 42 (84.0%) patients for the combination of both methods. Further statistical analysis showed significant difference in sensitivity between CT‐guided PNBs, or the combination of both methods, and EBs (all P < 0.05), and no difference between CT‐guided PNBs and the combination (P > 0.05). However, the combination of both methods appears to have the highest sensitivity in the detection of malignancies or TB diseases.ConclusionCompared with EB, CT‐guided PNB has a high diagnostic yield for the detection of TB and malignancy in patients with multifocal pulmonary lesions with endobronchial involvement. When the two biopsies are combined, it appears to provide an incremental diagnostic value for the pulmonary lesions.

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Tumor seeding along the needle track after percutaneous lung biopsy

Cited by 7 publications

References 1 publication

Prevention of tumor seeding during needle biopsy by chemotherapeutic-releasing gelatin sticks

Prevention of tumor seeding during needle biopsy by chemotherapeutic-releasing gelatin sticks

Safety and Diagnostic Efficacy of Image-Guided Biopsy of Small Renal Masses

Comparison of computed tomography‐guided percutaneous needle biopsy and endobronchial biopsy in the diagnosis of multifocal pulmonary lesions

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