Tumor-related prognostic factors for remission of brain metastases after radiotherapy

Nieder, Carsten; Berberich, W; Schnabel, K.

doi:10.1016/s0360-3016(97)00154-5

Cited by 105 publications

(41 citation statements)

References 15 publications

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“…As alluded to earlier, Nieder et al (1997) have demonstrated the complete remission rates differed by underlying histology when WBRT was applied. Certain histological types are thought to be more "radioresistant" than others.…”

mentioning

confidence: 70%

“…Response of BM to WBRT is related to lesion size, underlying histology and dose. Nieder et al (1997) demonstrated that complete radiological remission to WBRT differed by histology -37% for small-cell carcinoma, 35% for breast cancer, 25% for squamous cancer, and 14% for non-breast adenocarcinoma. The size of the underlying lesion significantly influenced response rate (52% for lesions below 0.5 cc and 0% for lesions above 10 cc).…”

Section: How Should We Treat Patients With Limited Bm?mentioning

confidence: 99%

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Brain Metastases

Vellayappan¹,

Sahgal²,

Redmond³

et al. 2017

Controversies in Radiation Oncology

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mentioning

confidence: 70%

Section: How Should We Treat Patients With Limited Bm?mentioning

confidence: 99%

Brain Metastases

Vellayappan¹,

Sahgal²,

Redmond³

et al. 2017

Controversies in Radiation Oncology

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“…WBRT is often used alone in RPA class III patients whose alternative is best supportive care. In this setting, both overall response rate and neurologic improvement range from 50% to 60% and survival improves from between 1 and 2 to 4 months in most series [22][23][24]. WBRT is often used in conjunction with local treatment (surgery or stereotactic radiosurgery) in RPA class I/II patients whose alternative is local treatment alone or local treatment combined with systemic treatment.…”

Section: Whole Brain Radiation Therapymentioning

confidence: 99%

Modern Multidisciplinary Management of Brain Metastases

Thomas¹,

Dunbar

2010

Curr Oncol Rep

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Ideal management of brain metastases (BMs) requires simultaneous control of the existing brain metastasis (local brain control), prevention of future BMs (distant brain control), and control of the systemic cancer (systemic control). Available tools include whole brain radiation therapy (WBRT), surgery, stereotactic radiosurgery (SRS), and systemic therapies, such as chemotherapies, biologic agents, and radiosensitizing agents. Selecting the combination of these tools is highly individualized and is impacted by numerous factors involving the tumor, patient, provider, and evolving evidence. Historically, patients received WBRT, either alone or with local treatments (surgery or SRS). However, concern about the effects of WBRT, coupled with improvements in local control and survival in select patients, with the combination treatment, has led to a reconsideration of the role of WBRT. Additionally, there have been advancements in the efficacy and tolerance of systemic therapies and clarification regarding the relative risks and symptoms of tumor recurrence versus treatment complications. Thankfully, individualizing modern multidisciplinary management for patients with BMs is being aided by numerous recently completed, ongoing, and planned prospective series.

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Section: Introductionmentioning

confidence: 99%

“…Melanoma is regarded as a radioresistant histology due to the observed poor response to conventional radiation therapy [1]. Historically, whole brain radiotherapy has been used to treat melanoma brain metastasis yielding poor outcomes [1]. Stereotactic radiosurgery (SRS), which involves the delivery of an ablative dose of radiation to an intracranial tumor using a highly focused technique, has been used to treat melanoma brain metastases.…”

Section: Introductionmentioning

confidence: 99%

Pathologic complete response of a solitary melanoma brain metastasis after local ablative radiation therapy: case report

Clarke

Chaudhury

et al. 2009

Med Oncol

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A 73-year-old female with malignant melanoma metastatic to her left frontal lobe status post-gross total resection of the metastasis, whole brain radiotherapy, and Gamma Knife-based stereotactic radiosurgery for local recurrence presented with an area of increasing enhancement on follow-up magnetic resonance imaging (MRI) and hypermetabolic lesions on 18-fluorodeoxyglucose positron emission tomography/computerized tomography (18FDG PET/CT) of the brain suspicious for tumor recurrence. Surgical resection of the lesion was performed showing radiation necrosis with no evidence of tumor. The patient was alive 1 year after her second craniotomy. This case illustrates that despite being perceived as a radioresistant histology, complete local eradication of melanoma is possible with ablative dose regimens. Prolonged survival is possible in patients with limited metastatic melanoma if local tumor control is achieved.

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Tumor-related prognostic factors for remission of brain metastases after radiotherapy

Cited by 105 publications

References 15 publications

Brain Metastases

Brain Metastases

Modern Multidisciplinary Management of Brain Metastases

Pathologic complete response of a solitary melanoma brain metastasis after local ablative radiation therapy: case report

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