Tumor-reactive IgE antibodies in plasma of patients with gastrointestinal carcinomas

Berczi, István; Holford-Strevens, V.; McMorris, L S; Thorlakson, Robert H.; Thorlakson, T. Kenneth; Sehon, A.H.

doi:10.1007/bf00205357

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…Elevated serum IgE levels as prognostic indicators of malignancy have been suggested for breast cancers, carcinomas of the oral cavity, cervix and uterus, as well as bronchial carcinomas, compared to a control population (Blondal & Nou, 1981; Ownby et al ., 1982; Jankovic et al ., 1985; Vijayakumar et al ., 1986 Lal et al ., 1988). IgE tumour antibodies have been found in the plasma of gastrointestinal carcinoma patients, which decreased or disappeared after surgical treatment (Berczi et al ., 1983). Elevated serum IgE levels have also been found in Hodgkin's disease patients (Wiemels et al ., 2004).…”

Section: Discussionmentioning

confidence: 99%

“…A potential link between cancer and the immune system, particularly IgE, has been investigated by numerous researchers, with varied results (Winters & Heiner, 1976; Blondal & Nou, 1981; Ownby et al ., 1982; Berczi et al ., 1983; Jankovic et al ., 1985; Levo et al ., 1985; Vijayakumar et al ., 1986; Lal et al ., 1988; Eckschlager et al ., 2004; Wiemels et al ., 2004). However, there has been little or no research on the role of IgE in the pathogenesis and development of neurofibromatosis, particularly in neurofibromas and plexiform neurofibromas.…”

Section: Introductionmentioning

confidence: 99%

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Serum IgE levels in neurofibromatosis 1

Geller¹,

Ribeiro²,

Araujo³

et al. 2006

Int J Immunogenetics

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A descriptive case study was performed on 75 patients with NF1 (neurofibromatosis type 1) from the CNNF (Brazil) database. Serum IgE levels were determined using the IgE radioimmunosorbent test, with the reference values of 75-502 IU mL(-1). The patients were divided into groups, with 25 patients presenting plexiform neurofibromas, 25 presenting neurofibromas and 25 presenting no neurofibromas. The purposes of this study were to determine the serum IgE levels of patients with NF1 presenting plexiform neurofibromas, neurofibromas and no neurofibromas, as well as to determine possible correlations between serum IgE levels and the size of the plexiform neurofibromas and neurofibromas presented by these patients. Elevated serum IgE levels were observed in all the patient groups. We did not observe a correlation between IgE levels and age in these patients; however, we did observe correlations between IgE levels and neurofibroma and plexiform neurofibroma size. We suggest further studies to confirm these results and to investigate in greater depth the possible role of IgE in the development and growth of neurofibromas and plexiform neurofibromas in NF1.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum IgE levels in neurofibromatosis 1

Geller¹,

Ribeiro²,

Araujo³

et al. 2006

Int J Immunogenetics

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“…Moreover, the whealand-flare reaction could be transferred to healthy volunteers by the Prausnitz-Küstner test, in which the patient's serum was first injected intradermally and the tumor extract was injected into the same site 24 h later [22]. Tumorreactive IgE antibodies were also demonstrated in this laboratory by an appropriate "double-antibody" test in approximately one-third of patients with colon cancer [5]; these lgE antibodies decreased or disappeared 8-13 days after surgical removal of the tumor.…”

Section: Introductionmentioning

confidence: 99%

Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus

Nagy

Berczi

Sehon

1991

Cancer Immunol Immunother

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Two IgE-producing hybridomas were established from spleen cells of Balb/c mice, which had been immunized with mouse mammary tumor virus (MMTV). These IgE monoclonal antibodies (mAbs) reacted specifically with the major envelope glycoprotein (gp36) of MMTV, as established by the immunoblot assay and by passive cutaneous anaphylaxis. The effect of the IgE mAbs (produced by clone A8) on the growth of the MMTV-secreting mammary adenocarcinoma H2712 was investigated in syngeneic C3H/HeJ mice. The mice were inoculated s.c. with either 10(5) (approximately 100 x LD50) or 10(6) (approximately 1000 x LD50) tumor cells and received repeated i.p. injections of 25 micrograms anti-gp36 IgE mAbs at 4-day intervals for 8 weeks. This treatment prevented the development of subcutaneous tumors in 50% of the animals. Similar protection was observed when the tumor cells (10(5)/animal) were injected i.p. 4 days prior to the beginning of the i.p. treatment consisting of injections of 25 micrograms mAbs at 4-day intervals for 6 weeks. However, these mAbs did not protect C3H/HeJ mice against the MMTV-negative MA16/c carcinoma cells. Hence, these results support the view that IgE-mediated cytotoxic mechanisms may play an immunologically specific antitumor surveillance role and that laboratory-induced antitumor IgE mAbs have the potential of specific therapeutic agents for in vivo destruction of tumor cells.

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“…An additional observation is that in SJL mice, an strain which is genetically suppressed for IgE production, there is a high incidence of spontaneous lymphoreticular neoplasms [7], Furthermore, an IgE response di rected against tumor antigens has been described in the mouse [8] and human [9], but its importance in the in vivo host resistance against the tumor is not known.…”

Section: Introductionmentioning

confidence: 99%

A Role for Anaphylactic Sensitization in Tumor Control

Correnti¹,

Sanchez²,

Chacón³

1985

Int Arch Allergy Immunol

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In order to evaluate the possible preventive role of an anaphylactic condition on tumor development, C57BL/6J mice were immunized or hyperimmunized by the intraperitoneal route with egg albumin in alum before the chemical induction of fibrosarcoma. Preimmunization using a protocol which elicits an optimal IgE response produced: (1) a significant reduction of tumor incidence; (2) an increase of survival time, and (3) a decrease of tumor growth rate in animals with higher IgE titers (> 640). On the other hand, hyperimmunized mice, which were suppressed in their anti-egg albumin IgE response, showed no changes in tumor incidence and survival time when compared to controls. Our results suggest a suppressive effect on tumor development related to the ability of the animal to mount an IgE response to antigens unrelated to the tumor.

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Tumor-reactive IgE antibodies in plasma of patients with gastrointestinal carcinomas

Cited by 13 publications

References 24 publications

Serum IgE levels in neurofibromatosis 1

Serum IgE levels in neurofibromatosis 1

Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus

A Role for Anaphylactic Sensitization in Tumor Control

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