Abstract:Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor radiosensitization. Two prominent targets are endoglin (CD105), a transforming growth factor β co-receptor, and the melanoma cell adhesion molecule (CD1046), present also on many tumors. In our recent in vitro study, we constructed and evaluated a plasmid for simultaneous silencing of these two targets. In the current study, our aim was to explore the therapeu… Show more
“…This approach allows for the direct transfer of therapeutic genes into tumor cells, thereby exerting direct or indirect anti-tumor effects. [124][125][126] Using GET technology, the successful delivery of the IL-12 gene into tumor cells has been achieved, effectively activating T cells, NK cells, and tumor-infiltrating lymphocytes in the tumor microenvironment. This has significantly inhibited tumor growth and induced apoptosis in tumor cells.…”
Section: Tumor Treatmentmentioning
confidence: 99%
“…This approach allows for the direct transfer of therapeutic genes into tumor cells, thereby exerting direct or indirect anti-tumor effects. 124–126…”
Section: Electroporation For Gene Therapy In Clinical Settingsmentioning
Gene therapy is a promising disease treatment approach by editing target genes, and thus plays a fundamental role in precision medicine. To ensure gene therapy efficacy, the effective delivery of...
“…This approach allows for the direct transfer of therapeutic genes into tumor cells, thereby exerting direct or indirect anti-tumor effects. [124][125][126] Using GET technology, the successful delivery of the IL-12 gene into tumor cells has been achieved, effectively activating T cells, NK cells, and tumor-infiltrating lymphocytes in the tumor microenvironment. This has significantly inhibited tumor growth and induced apoptosis in tumor cells.…”
Section: Tumor Treatmentmentioning
confidence: 99%
“…This approach allows for the direct transfer of therapeutic genes into tumor cells, thereby exerting direct or indirect anti-tumor effects. 124–126…”
Section: Electroporation For Gene Therapy In Clinical Settingsmentioning
Gene therapy is a promising disease treatment approach by editing target genes, and thus plays a fundamental role in precision medicine. To ensure gene therapy efficacy, the effective delivery of...
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