Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer

Abstract

Background: Tumor purity plays a vital role in the biological process of solid tumors, but its function in gynecologic cancers remains unclear. This study explored the correlation between tumor purity and immune function of gynecological cancers and its reliability as a prognostic indicator of immunotherapy. Methods: Gynecological cancer-related datasets were downloaded from The Cancer Genome Atlas (TCGA). Tumor purity was calculated by the ESTIMATE algorithm. A LASSO Cox regression analysis was performed to construct the risk score model. A Kaplan–Meier Plotter was used to explore the relationships between tumor purity and cancer prognosis. We performed the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) to explore the pathways in the subgroups. A nomogram was used to quantitatively assess the cancer prognosis. Results: Tumor purity was negatively correlated with B cell infiltration in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Approximately 420 genes were positively associated with B cell infiltration and CESC prognosis and were enriched in immune-related signaling pathways. There were 11 key genes used to construct a risk score model. The low-risk group had a higher immune score and better prognosis than the high-risk group. A nomogram based on risk score, T stage, and clinical-stage had good predictive value in quantitatively evaluating CESC prognosis. Conclusions: This study is the first to reveal the correlation between tumor purity and immunity in CESC and suggests that low-risk patients may be more sensitive to immunotherapy. This provides a theoretical basis for the clinical treatment of CESC.

A novel anoikis-related gene signature to predict the prognosis, immune infiltration, and therapeutic outcome of lung adenocarcinoma

“…Our conclusion agrees with the report by Qu et al , who constructed a risk model according to immune-related genes ( 39 ). Deng et al reported that the low tumor purity group was mainly enriched in immune-related pathways, such as T cell, B cell, and macrophage pathways, they thought immune cells might kill tumor cells leading to low tumor purity associated with better prognosis ( 40 ). In this study, we found that high tumor purity suggested poor prognosis which is consistent with the conclusion of Deng.…”

RBM15 m6A modification‐mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling

“…[39][40][41] Despite great advancement in the therapeutic approaches for CC in recent years, the median survival period of CC patients at advanced stages remains only 16.8 months. 42,43 This raises As a widely recognized oncogene, OTUB2 has been identified as a contributor to cancer stemness and metastasis. 44 Additionally, OTUB2 is deeply involved in the regulation of cellular behaviors of cancer cells.…”

Values of a novel pyroptosis-related genetic signature in predicting outcome and immune status of pancreatic ductal adenocarcinoma

“…Besides, the antitumor immune cells, such as CD8 + T cells, activated B cells, and natural killer T cells, were upregulated in the C1 cluster. The reason might be that lower tumor purity, consistent with a higher immune score, was related to more robust immune responses, leading to a longer OS [ 16 ].…”