Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3′-untranslated region of ErbB4 in breast cancer

Bagheri, Fatemeh; Tanha, Hamzeh Mesrian; Naeini, Marjan Mojtabavi; Ghaedi, Kamran; Azadeh, Mansoureh

doi:10.3892/mmr.2016.5078

Cited by 24 publications

(19 citation statements)

References 25 publications

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“…Single-nucleotide polymorphisms (SNPs) in miRNAs or miRNAs-targets are associated with the development of several tumors. For example, in breast cancer, polymorphisms in the 3′-UTR of the ErbB4 gene could affect miRNA binding sites resulting in post-translational dysregulation of mRNA and a predisposition to tumor development (128). In gastric cancer, SNPs in miRNA machinery genes was strictly associated with cancer susceptibility and malignant behavior (Dicer and GEMIN4), or lymphatic metastasis (GEMIN4 and Ago1) (129).…”

Section: Mirna In Tumorsmentioning

confidence: 99%

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

et al. 2020

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microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They target more than one mRNAs, thus influencing multiple molecular pathways, but also mRNAs may bind to a variety of miRNAs, either simultaneously or in a context-dependent manner. miRNAs biogenesis, including miRNA transcription, processing by Drosha and Dicer, transportation, RISC biding, and miRNA decay, are finely controlled in space and time.miRNAs are critical regulators in various biological processes, such as differentiation, proliferation, apoptosis, and development in both health and disease. Their dysregulation is involved in tumor initiation and progression. In tumors, they can act as onco-miRNAs or oncosuppressor-miRNA participating in distinct cellular pathways, and the same miRNA can perform both activities depending on the context.In tumor progression, the angiogenic switch is fundamental. miRNAs derived from tumor cells, endothelial cells, and cells of the surrounding microenvironment regulate tumor angiogenesis, acting as pro-angiomiR or anti-angiomiR.In this review, we described miRNA biogenesis and function, and we update the non-classical aspects of them. The most recent role in the nucleus, as transcriptional gene regulators and the different mechanisms by which they could be dysregulated, in tumor initiation and progression, are treated. In particular, we describe the role of miRNAs in sprouting angiogenesis, vessel co-option, and vasculogenic mimicry. The role of miRNAs in lymphoma angiogenesis is also discussed despite the scarcity of data.The information presented in this review reveals the need to do much more to discover the complete miRNA network regulating angiogenesis, not only using high-throughput computational analysis approaches but also morphological ones.

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Section: Mirna In Tumorsmentioning

confidence: 99%

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

et al. 2020

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“…Lately, it was indicated that SNPs' existence at 3′ UTR of target gene in place of binding site for micro-RNAs has an important role in the development of breast cancer. Interaction of microRNAs with 3′UTR of ErbB4 mRNA is more frequent when T allele at the rs1836724 position is replaced by C allele [54]. Micro-RNAs show oncogenic or tumor suppressor activity in cancerous cells.…”

Section: Regulation Of Msi1 In Different Cancersmentioning

confidence: 99%

Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells

et al. 2020

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RNA-binding protein, musashi1 (MSI1), is a main protein in asymmetric cell division of the sensory organ precursor cells, whereas its expression is reported to be upregulated in cancers. This protein is a critical element in proliferation of stem and cancer stem cells, which acts through Wnt and Notch signaling pathways. Moreover, MSI1 modulates malignancy and chemoresistance of lung cancer cells via activating the Akt signaling. Due to the main role of MSI1 in metastasis and cancer development, MSI1 would be an appropriate candidate for cancer therapy. Downregulation of MSI1 inhibits proliferation of cancer stem cells and reduces the growth of solid tumors in several cancers. On the other hand, MSI1 expression is regulated by microRNAs in such a way that several different tumor suppressor miRNAs negatively regulate oncogenic MSI1 and inhibit migration and tumor metastasis. The aim of this review is summarizing the role of MSI1 in stem cell proliferation and cancer promotion.

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“…MiRNAs are chief regulators of the cell and their deregulation has been recognized in many cancer kinds with high clinical consequence . During tumorigenesis and progression of various types of cancer, dysregulated miRNAs play either tumor‐suppressor or oncogenic roles, depending on their target genes.…”

Section: Discussionmentioning

confidence: 99%

Down‐regulation of microRNA‐19b in hormone receptor‐positive/HER2‐negative breast cancer

Maleki

Ghaedi

Shahanipoor

et al. 2018

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miR-19b (miR-19b-3p) has been reported to be correlated with either favorable or unfavorable events in several cancers. However, no study has been conducted to evaluate the expression level of miR-19b in patients with breast cancer (BC). This study was aimed to investigate the expression level of miR-19b in human malignant and healthy breast tissues with histopathology of ER+/PR+/HER2-. We performed a miRNA real-time PCR to detect differential expression of miR-19b in 40 BC, including 17 BC with familial background and 23 BC without familial background, and 12 non-tumoral tissues. Moreover, a bioinformatics prediction upon miR-19b functionality in BC cells was performed. The miR-19b expression level was significantly down-regulated in BC, BC with familial background, and BC without familial background compared with its expression in normal tissue (p value, <0.0001; fold change, -7.45; p value, 0.0003; fold change, -6.45; and p value, 0.0005; fold change, -8.41, respectively). Moreover, according to the AUCs (area under curve) of receiver operating characteristic (ROC) curves, miR-19b can significantly distinguish all defined categories. Last, in agreement with our experimental findings, proteoglycans in cancer, pathways in cancer, FoxO signaling pathway, central carbon metabolism in cancer, p53 signaling pathway, transcriptional misregulation in cancer, and prolactin signaling pathway were predicted as miR-19b-related signaling pathways. In summary, down-regulation of miR-19b in BC vs healthy tissue suggests that mir-19b can function as a tumor suppressor. Our results shed additional information on controversial expression pattern of miR-19b depending on different cancer types.

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Tumor-promoting function of single nucleotide polymorphism rs1836724 (C3388T) alters multiple potential legitimate microRNA binding sites at the 3′-untranslated region of ErbB4 in breast cancer

Cited by 24 publications

References 25 publications

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells

Down‐regulation of microRNA‐19b in hormone receptor‐positive/HER2‐negative breast cancer

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