Tumor profiles and carcinogenic potency in rodents and humans: Value for cancer risk assessment

Benigni, Romualdo; Giuliani, Alessandro

doi:10.1080/10590509909373507

Cited by 11 publications

(1 citation statement)

References 26 publications

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“…When considering the prediction of mutagenicity and carcinogenicity, we have generally been considering the results from the rodent assay. It is accepted that the rodent assay is a satisfactory method to identify whether or not a chemical may be carcinogenic to humans, even if it is not possible to extrapolate with certainty specific tumor responses [49]. It should, therefore, be possible to extrapolate carcinogenic potency to predict the effects on ecologically relevant species.…”

Section: Introductionmentioning

confidence: 99%

Quantitative structure‐activity relationships for human health effects: Commonalities with other endpoints

Cronin

Dearden

Walker

et al. 2003

Enviro Toxic and Chemistry

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Abstract-This article describes the use of quantitative structure-activity relationships (QSARs) to predict toxicity endpoints for ecologically relevant and human-surrogate species. The interrelationships between the endpoints, and the possibilities of exploring the commonalities of chemical action from one species to another as well as from one endpoint to another, are evaluated. A number of toxic endpoints are discussed including mutagenicity and carcinogenicity; developmental toxicity (teratogenicity); acute toxicity; skin sensitization; skin, eye, and sensory irritation; and the modeling of membrane permeability. A number of electrophilic molecular substructures have been identified that are common to a number of toxicities. It is postulated that if such a substructure is observed in a molecule, it may exhibit a range of toxicities. Further, there appear to be relationships between the toxicity to ecologically relevant and human-surrogate species, which may allow for appreciation and possible extrapolation in both directions. Overall, however, QSARs are limited by the paucity of available toxicological data and information.

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Section: Introductionmentioning

confidence: 99%