Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer

Bernstein, Jonathan M; Kershaw, Lucy; Withey, Stephanie; Lowe, Natalie; Homer, Jarrod J; Slevin, Nicholas J; Bonington, Suzanne C; Carrington, Bernadette M; West, Catharine M L

doi:10.1016/j.oraloncology.2015.01.013

Cited by 19 publications

(27 citation statements)

References 26 publications

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“…Pretreatment K trans (median value=0.19–0.64min −1 ) has been reported to predict treatment response to CRT, 4–6 induction therapy, 7 and short-term survival in patients with HNSCC. 8, 9 We also observed that higher pretreatment K trans was associated with better OS.…”

Section: Discussionmentioning

confidence: 99%

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Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τ_i): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Chawla¹,

Loevner²,

Kim

et al. 2017

AJNR Am J Neuroradiol

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Background and Purpose Shutter speed model analysis of DCE-MRI allows estimation of τi, a measure of cellular energy metabolism and Ktrans, a measure of hemodynamics. The purpose of this study was to investigate the prognostic utility of pretreatment τi and Ktrans in predicting OS in patients with HNSCC and to stratify p16-positive patients based upon survival outcome. Materials and Methods A cohort of 60 patients underwent DCE-MRI prior to treatment. Median τi and Ktrans values from metastatic nodes were computed from each patient. Kaplan-Meier analyses were performed to associate τi and Ktrans and their combinations with OS for first 2, 5-years and beyond (median duration>7-years). Results By last date of observation, 18 patients had died and median follow-up for surviving patients (n=42) was 8.32-years. Patients with high τi (4-deaths) had significantly (p=0.014) prolonged OS by 5-years compared to those with low τi (13-deaths). Similarly, patients with high τi (4-deaths) had significantly (p=0.006) longer OS at long-term duration than those with low τi (14-deaths). However, Ktrans was a significant predictor for only 5-years follow-up period. There was some evidence (p<0.10) to suggest that τi and Ktrans were associated with OS for first 2-years. Patients with high τi and high Ktrans were associated with significantly (p<0.01) longer OS compared to other groups for all follow-up periods. Additionally, p16-positive patients with high τi and high Ktrans demonstrated a trend towards the longest OS. Conclusions Combined analysis of τi and Ktrans provided the best model to predict OS in HNSCC patients.

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Section: Discussionmentioning

confidence: 99%

“…The potential of pretreatment K trans in predicting short-term response 4–7 as well as OS in HNSCC patients has been reported. 8, 9 Patients treated with CRT and with high baseline K trans from metastatic nodes were associated with an improved prognosis compared to patients with low baseline K trans 8, 9 .…”

Section: Introductionmentioning

confidence: 99%

Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τ_i): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Chawla¹,

Loevner²,

Kim

et al. 2017

AJNR Am J Neuroradiol

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“…A study was performed on 37 HNSCC patients undergoing induction chemotherapy (IC) by Bernstein et al 46 and the median baseline tumor plasma flow (F p ) was 53.2 ml/100 ml/min in 25 responders and 23.9 in 12 non-responders (P = 0.027). Median baseline F p in lymph nodes was 25.8 ml/100 ml/min for 37 nodes in 25 responders and 17.1 for 15 nodes in 12 non-responders (p = 0.066) and frequency of IC response in 37 patients was 68% overall, 83% for tumor F p above the median (40.6 ml/100 ml/min) and 45% below the median.…”

Section: Imaging Findingsmentioning

confidence: 99%

Evaluation of Head and Neck Tumors with Functional MR Imaging

Jansen

Parra

et al. 2016

Magnetic Resonance Imaging Clinics of North America

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Synopsys Head and neck (HN) cancer is one of the most common cancers worldwide. Magnetic Resonance Imaging (MRI) based diffusion and perfusion techniques enable the non-invasive assessment of tumor biology and physiology, which supplement information obtained from standard structural scans. Diffusion and perfusion MRI techniques provide novel biomarkers that can aid the monitoring pre-, during, and post-treatment stages to improve patient selection for therapeutic strategies, provide evidence for change of therapy regime, and evaluation of treatment response. This review discusses pertinent aspects of the role of diffusion and perfusion MRI and computational analysis methods in studying HN cancer.

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“…Also plasma flow has shown to react in patients undergoing induction chemotherapy for the regional tumor [ 47 ]. The median baseline tumor plasma flow was 53 ml/100 ml/min in 25 responders and 24 ml/100 ml/min in 12 non-responders.…”

Section: Response Evaluation During Therapymentioning

confidence: 99%

“…The median baseline tumor plasma flow was 53 ml/100 ml/min in 25 responders and 24 ml/100 ml/min in 12 non-responders. In lymph nodes, differences were not significantly different between non-responders and responders [ 47 ]. After appropriate validation, this method may be potentially used to guide treatment modification in patients.…”

Section: Response Evaluation During Therapymentioning

confidence: 99%

Functional MRI for Treatment Evaluation in Patients with Head and Neck Squamous Cell Carcinoma: A Review of the Literature from a Radiologist Perspective

et al. 2018

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Purpose of reviewTo show the role of functional MRI in patients treated for head and neck squamous cell carcinoma.Recent findingsMRI is commonly used for treatment evaluation in patients with head and neck tumors. However, anatomical MRI has its limits in differentiating between post-treatment effects and tumor recurrence. Recent studies showed promising results of functional MRI for response evaluation.SummaryThis review analyzes possibilities and limitations of functional MRI sequences separately to obtain insight in the post-therapy setting. Diffusion, perfusion and spectroscopy show promise, especially when utilized complimentary to each other. These functional MRI sequences aid in the early detection which might improve survival by increasing effectiveness of salvage therapy. Future multicenter longitudinal prospective studies are needed to provide standardized guidelines for the use of functional MRI in daily clinical practice.

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Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer

Cited by 19 publications

References 26 publications

Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τ_i): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τ_i): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Evaluation of Head and Neck Tumors with Functional MR Imaging

Functional MRI for Treatment Evaluation in Patients with Head and Neck Squamous Cell Carcinoma: A Review of the Literature from a Radiologist Perspective

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Tumor plasma flow determined by dynamic contrast-enhanced MRI predicts response to induction chemotherapy in head and neck cancer

Cited by 19 publications

References 26 publications

Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τi): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τi): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Evaluation of Head and Neck Tumors with Functional MR Imaging

Functional MRI for Treatment Evaluation in Patients with Head and Neck Squamous Cell Carcinoma: A Review of the Literature from a Radiologist Perspective

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Product

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Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τ_i): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas

Dynamic Contrast-Enhanced MRI–Derived Intracellular Water Lifetime (τ_i): A Prognostic Marker for Patients with Head and Neck Squamous Cell Carcinomas