Tumor pH and metastasis: a malignant process beyond hypoxia

Thews, Oliver; Riemann, Anne

doi:10.1007/s10555-018-09777-y

Cited by 136 publications

(101 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, pH levels can reect variations in the local, regional, and systemic acid-base balance which is related to health and disease. 48 Furthermore, the variation in pH values can reect the activity of many physiological, biological and medical processes such as enzymatic reaction, tumour metastasis, 49,50 wound healing 51,52 cellular growth 13,53 etc. Therefore, in situ assessment of the pH levels of body uids, such as sweat, tears, urine and saliva could provide the relevant information necessary for the early detection of many diseases.…”

Section: Importance Of Wearable Ph Sensing For Health Monitoringmentioning

confidence: 99%

Flexible potentiometric pH sensors for wearable systems

2020

View full text Add to dashboard Cite

show abstract

Section: Importance Of Wearable Ph Sensing For Health Monitoringmentioning

confidence: 99%

Flexible potentiometric pH sensors for wearable systems

2020

View full text Add to dashboard Cite

show abstract

“…Chronic acidosis, such as hypoxia, induces LD formation in cancer cells in the primary tumor microenvironment, with TGF-β2 as a key signaling actor to drive LD biogenesis through the uptake of FAs. Furthermore, TGF-β2-stimulated LD accumulation promotes acidosisadapted cancer cell invasiveness by inducing EMT, which represents a prerequisite to support distant metastatic spreading 114,115 . In addition, primary tumor cells produce exosomes that deliver various kinds of functional molecules, including metabolites (lipids and regulatory proteins), contribute to MDSC recruitment in secondary target organs and are taken up by organ-specific cells to prepare the PMN 116 .…”

Section: The Priming Phasementioning

confidence: 99%

The dynamic behavior of lipid droplets in the pre-metastatic niche

2020

View full text Add to dashboard Cite

The pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed.

show abstract

“…Lactate accumulation and extracellular matrix acidification due to the enhanced glycolytic rate can promote EMT by regulating the expression of EMT-related proteins (25). Moreover, extracellular acidosis can activate matrix-metalloproteinases (MMPs), which play a crucial role in the degradation of extracellular matrix and subsequent invasion of cancer cells into the vascular wall (26). The increase in the levels of the glycolysis byproduct methylglyoxal, as well as the overexpression of glucose transporter 1 (GLUT1) and hexokinase 2 (HK2), have also FIGURE 1 | The effects of metabolic reprogramming in cancer development and metastasis.…”

Section: Metabolic Reprogramming and Metastatic Potential Of Tumor Cellsmentioning

confidence: 99%

The Role of Aberrant Metabolism in Cancer: Insights Into the Interplay Between Cell Metabolic Reprogramming, Metabolic Syndrome, and Cancer

Gong²,

2020

Front. Oncol.

View full text Add to dashboard Cite

Metabolic syndrome (MetS) is characterized by hyperglycemia, hypertension, dyslipidemia and abdominal obesity. Patients with MetS or other metabolic disorders are more susceptible to cancer development and recurrence and have a worse long-term prognosis. Moreover, the metabolic reprogramming observed in cancer cells has also been described as one of the new hallmarks of cancer. Thus, aberrant metabolism has been proposed as an important risk factor for cancer. Chronic inflammation, reactive oxygen species (ROS), and oncogenic signaling pathways are considered as main potential triggers. Considering the strong association between metabolism and cancer, metabolism-modulating drugs, including metformin and statins, as well as adopting a healthy lifestyle, have been extensively investigated as strategies to combat cancer. Furthermore, strategies that interfere with the metabolic rewiring of cells may also have potent anti-cancer effects. In this article, we provide a comprehensive review of current knowledge on the relationship between aberrant metabolism and cancer and discuss the potential use of metabolism-targeting strategy for the treatment of cancer.

show abstract

Tumor pH and metastasis: a malignant process beyond hypoxia

Cited by 136 publications

References 186 publications

Flexible potentiometric pH sensors for wearable systems

Flexible potentiometric pH sensors for wearable systems

The dynamic behavior of lipid droplets in the pre-metastatic niche

The Role of Aberrant Metabolism in Cancer: Insights Into the Interplay Between Cell Metabolic Reprogramming, Metabolic Syndrome, and Cancer

Contact Info

Product

Resources

About