Tumor necrosis factor-α soluble receptor p55 (sTNFp55) and risk of preeclampsia in Peruvian women

Sanchez, Sixto E.; Zhang, Cuilin; Williams, Michelle A.; Ware-Jauregui, Suzie; Larrabure, Gloria; Bazul, Víctor; Farrand, Allen L.

doi:10.1016/s0165-0378(99)00064-9

Cited by 24 publications

(12 citation statements)

References 31 publications

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“…It was found that sub-Saharan African women with PE and eclampsia had a significantly higher sTNFp55 concentration than normotensive controls (eclampsia levels were greater than PE levels) [32]. Similarly, other authors noted that concentrations of sTNFp55 were correlated with the severity of PE [32][33][34].…”

Section: Discussionmentioning

confidence: 92%

Association of the TNF2 Allele with Eclampsia

Kaiser

Grehan

Brennecke

et al. 2004

Gynecol Obstet Invest

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The genetic background predisposing pregnant women to the disorder pre-eclampsia/eclampsia (PE/E) is still unknown. There is compelling evidence to suspect involvement of the immune system in the development of PE/E. The aim of this current study was to investigate whether there is an association between the tumor necrosis factor (TNF)-α –307 polymorphism and PE or eclampsia. In this study, 51 cases of eclampsia, 122 cases of PE and 100 normotensive control cases were genotyped for the TNF-α –307 polymorphism. We found a significant difference between the TNF2 allele frequencies of eclamptic and normotensive controls (χ² = 6.3 and p = 0.025), but not of pre-eclamptic and normotensive controls (χ² = 0.5 and p = 1.0). We conclude from this study that the TNF2 allele contributes to the occurrence of eclampsia in our population.

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Section: Discussionmentioning

confidence: 92%

Association of the TNF2 Allele with Eclampsia

Kaiser

Grehan

Brennecke

et al. 2004

Gynecol Obstet Invest

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“…The concentrations of TNF-α and its receptor have both been seen to be elevated in serum and amniotic fluid of preeclamptic patients [9]. Sanchez et al [25] showed that the plasma level of soluble TNF receptor (sTNFp55), which indicated excessive release of TNF-α, was intensively associated with the occurrence of pre-eclampsia. However, not all experiments showed the same results.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the expression of cytokine – receptor genes in normal and preeclamptic human placentas using DNA microarrays

Pang¹,

Xing²

2003

Journal of Perinatal Medicine

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“…The design of the study was previously described [6,10]. During the study period, women with preeclampsia and normotensive women were recruited from labor and delivery wards at the Materno-Perinatal Institute and the Dos de Mayo Hospital in Lima, Peru.…”

Section: Methodsmentioning

confidence: 99%

“…Metabolic disturbances consistently noted in preeclamptics include hypertriglyceridemia [1,2], excessive lipid peroxidation or oxidative stress [3], insulin resistance [1], sympathetic nervous system overreactivity [4], plasma elevation of proinflammatory cytokines [5,6], an imbalance in thromboxane and prostacyclin in favor of vasoconstriction [7,8] and elevated plasma homocysteine concentrations [9,10]. There is also considerable overlap between the epidemiological risk factors of preeclampsia and coronary heart disease given that obesity, sedentary life style, history of diabetes, and chronic hypertension are risk factors for both disorders.…”

Section: Introductionmentioning

confidence: 99%

Family History of Hypertension and Diabetes in Relation to Preeclampsia Risk in Peruvian Women

Sanchez

Zhang

Qiu

et al. 2003

Gynecol Obstet Invest

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In a case-control study of 169 preeclamptics and 201 controls, we assessed maternal parental history of chronic hypertension and diabetes in relation to preeclampsia risk among Peruvian women. Participants provided information on parental history of the two conditions and other covariates during postpartum interviews. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for confounding by age, parity and prepregnancy adiposity. In this population, women were more likely to know the diabetes status of their parents than their hypertension status. Compared with women without a parental history of hypertension, women with a parental history of hypertension experienced a 20% increased risk of preeclampsia (OR = 1.2; 95% CI 0.7–2.2) that did not reach statistical significance. Women with a positive parental history for diabetes had a 3.4-fold increased risk of preeclampsia (95% CI 1.4–8.4). Women with a positive parental history of both hypertension and diabetes, as compared with those whose parents had neither condition, experienced a 4.6- fold increased risk of preeclampsia (OR = 4.6; 95% CI 0.9–23.0). Our results are generally consistent with the thesis that parental history of hypertension and diabetes reflects genetic and behavioral factors whereby women may be predisposed to an increased risk of preeclampsia.

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Tumor necrosis factor-α soluble receptor p55 (sTNFp55) and risk of preeclampsia in Peruvian women

Cited by 24 publications

References 31 publications

Association of the TNF2 Allele with Eclampsia

Association of the TNF2 Allele with Eclampsia

Comparative study on the expression of cytokine – receptor genes in normal and preeclamptic human placentas using DNA microarrays

Family History of Hypertension and Diabetes in Relation to Preeclampsia Risk in Peruvian Women

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