Tumor Necrosis Factor-α-mediated Protein Kinases in Regulation of Scavenger Receptor and Foam Cell Formation on Macrophage

Hsu, Han‐Shui; Twu, Yuh-Ching

doi:10.1074/jbc.m003464200

Cited by 55 publications

(43 citation statements)

References 71 publications

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“…Our results show that TNFα is also capable of causing a decrease in both CD36 and MSR1 which has been confirmed by several in vitro studies in different models [53][54][55][56]. MSR1 expression appears to be regulated both transcriptionally and post-transcriptionally and likely involves the phosphatidylinositol 3-kinase/Rac1/PAK/JNK and phosphatidylinositol 3-kinase/Rac1/PAK/p38 pathways [53,54].…”

Section: Discussionsupporting

confidence: 58%

“…MSR1 expression appears to be regulated both transcriptionally and post-transcriptionally and likely involves the phosphatidylinositol 3-kinase/Rac1/PAK/JNK and phosphatidylinositol 3-kinase/Rac1/PAK/p38 pathways [53,54]. Boyer et al also found that CD36 expression is downregulated by TNFα in primary human MDMs, but in contrast to our results reported that TNFα treatment was sufficient to prevent rosiglitazone-mediated PPARγ activation [56].…”

Section: Discussioncontrasting

confidence: 55%

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Macrophage heterogeneity and cholesterol homeostasis: Classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL

Chu¹,

Tai²,

Beer³

et al. 2013

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Macrophages are centrally involved during atherosclerosis development and are the predominant cell type that accumulates cholesterol in the plaque. Macrophages however, are heterogeneous in nature reflecting a variety of microenvironments and different phenotypes may be more prone to contribute towards atherosclerosis progression. Using primary human monocyte-derived macrophages, we sought to evaluate one aspect of atherogenic potential of different macrophage phenotypes by determining their propensity to associate with and accumulate oxidized low density lipoprotein (oxLDL). Classically-activated macrophages treated simultaneously with interferon γ (IFNγ) and tumour necrosis factor α (TNFα) associated with less oxLDL and accumulated less cholesterol compared to untreated controls. The combined treatment of IFNγ and TNFα reduced the mRNA expression of CD36 and the expression of both cell surface CD36 and macrophage scavenger receptor 1 (MSR1) protein. Under oxLDL loaded conditions, IFNγ and TNFα did not reduce macrophage protein expression of the transcription factor peroxisome proliferator-actived receptor γ (PPARγ) which is known to positively regulate CD36 expression. However, macrophages treated with IFNγ did prevent the PPARγ-specific agonist rosiglitazone from upregulating cell surface CD36 protein expression. Our results demonstrate that the observed reduction of cholesterol accumulation in macrophages treated with IFNγ and TNFα following oxLDL treatment was due at least in part to reduced cell surface CD36 and MSR1 protein expression.

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Section: Discussionsupporting

confidence: 58%

Section: Discussioncontrasting

confidence: 55%

Macrophage heterogeneity and cholesterol homeostasis: Classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL

Chu¹,

Tai²,

Beer³

et al. 2013

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…1C and data not shown). Next, we examined the effect of Fab A77 on TNF-␣-initiated activation of p38, ERK and JNK in MonoMac 6 cells, which can also be activated through TNF receptors (27). TNF-␣ readily induced phosphorylation of p38, ERK and JNK MAPK (Fig.…”

Section: Fc␣ri-fcr␥-mediated Inhibitory Signaling Inhibits Non-itam-amentioning

confidence: 99%

Inhibitory ITAM Signaling by FcαRI-FcRγ Chain Controls Multiple Activating Responses and Prevents Renal Inflammation

Kanamaru

Pfirsch

Aloulou

et al. 2008

The Journal of Immunology

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Inhibitory signaling is an emerging function of ITAM-bearing immunoreceptors in the maintenance of homeostasis. Monovalent targeting of the IgA Fc receptor (FcαRI or CD89) by anti-FcαRI Fab triggers potent inhibitory ITAM (ITAMi) signaling through the associated FcRγ chain (FcαRI-FcRγ ITAMi) that prevents IgG phagocytosis and IgE-mediated asthma. It is not known whether FcαRI-FcRγ ITAMi signaling controls receptors that do not function through an ITAM and whether this inhibition requires Src homology protein 1 phosphatase. We show in this study that FcαRI-Fcγ ITAMi signals depend on Src homology protein 1 phosphatase to target multiple non-ITAM-bearing receptors such as chemotactic receptors, cytokine receptors, and TLRs. We found that anti-FcαRI Fab treatment in vivo reduced kidney inflammation in models of immune-mediated glomerulonephritis and nonimmune obstructive nephropathy by a mechanism that involved decreased inflammatory cell infiltration and fibrosis development. This treatment also prevented ex vivo LPS activation of monocytes from patients with lupus nephritis or vasculitis, as well as receptor activation through serum IgA complexes from IgA nephropathy patients. These findings point to a crucial role of FcαRI-FcRγ ITAMi signaling in the control of multiple heterologous or autologous inflammatory responses. They also identify anti-FcαRI Fab as a new potential therapeutic tool for preventing progression of renal inflammatory diseases.

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“…Various studies have shown the activation of JNK and p38 were mediated via PI 3-kinase/Rac1/PAK signaling pathway (2,47,70). Rac1 is important to LPS-induced pro-IL-1 in at least two aspects as follows: first the role of Rac1 in NADPH oxidase assemble/function (71), and second its role in PI 3-kinase/Rac1/ PAK signaling pathway.…”

Section: Lps Induces Ptp As Well As the Effect Of Lps-induced Ros Andmentioning

confidence: 99%

“…It is known that LPS has multiple and different effects on macrophages, such as the regulation of macrophage functions (1,2) and the induction of inflammatory cytokines such as IL-1, IL-6, and TNF (12,15,18,19). Although IL-1 is a potent inflammatory cytokine with various biological activities regulating host defense and immune responses (20), there has been less investigation of LPS induction of IL-1.…”

mentioning

confidence: 99%

Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

Hsu

Wen

2002

Journal of Biological Chemistry

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462

354

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Tumor Necrosis Factor-α-mediated Protein Kinases in Regulation of Scavenger Receptor and Foam Cell Formation on Macrophage

Cited by 55 publications

References 71 publications

Macrophage heterogeneity and cholesterol homeostasis: Classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL

Macrophage heterogeneity and cholesterol homeostasis: Classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL

Inhibitory ITAM Signaling by FcαRI-FcRγ Chain Controls Multiple Activating Responses and Prevents Renal Inflammation

Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

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