Tumor necrosis factor-α is a novel biomarker for peripheral neuropathy in type II diabetes mellitus: a clinical and electrophysiological study

EL-Badawy, Mohja A.; Farrag, Dina A.; El-Rehem, Samia M.R Abd; Elmahdi, Amira R; El-Sherbeny, Alyaa A; Hady, Emad A.M Abdel; Abdelsattar, Hoda A.; Abdelaziz, Doaa M.

doi:10.4103/1110-161x.205663

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…On contrast, EL-Badawy et al found nonsignificant negative correlation with conduction velocity of motor and sensory nerves of upper and lower limbs. This difference may be due to that the patients in EL-Badawy et al's study were 65% mixed axonal and demyelinating neuropathy and 35% only demyelinating neuropathy [46].…”

Section: Discussionmentioning

confidence: 83%

Tumor necrosis factor alpha in peripheral neuropathy in type 2 diabetes mellitus

Sheikh¹,

Alahmar²,

Salem³

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Objective: To compare serum levels of tumor necrosis factor alpha (TNF-α) between type 2 diabetes mellitus patients with and without peripheral neuropathy (PN). Also, to study the relation between peripheral nerves conduction velocity and serum level of TNF-α in those patients. Patients and methods: This study included three groups with 40 patients in each group. Diabetic PN patients (groups I and II) were compared with diabetic patients without PN (group III). Groups I and II differed in the duration of clinical neuropathy with less than 5 years in group I and more than 5 years in group II. All patients were subjected to general and neurological examination, neuropathy symptom score (NSS), neuropathy disability score (NDS), glycosylated hemoglobin (HbA1c), serum level of TNF-α and both sensory and motor nerve conduction study. Results: This study showed raised serum levels of TNF-α in diabetic patients with PN, more with increased duration of neuropathy. TNF-α levels showed statistically significant negative correlation with nerve conduction velocity but positive correlations with each of neuropathy disability score, neuropathy symptom score, and glycosylated hemoglobin. Conclusion: TNF-α might be involved in the pathogenesis of diabetic PN, and its serum level might be used as a biomarker for the severity of diabetic PN.

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Section: Discussionmentioning

confidence: 83%

Tumor necrosis factor alpha in peripheral neuropathy in type 2 diabetes mellitus

Sheikh¹,

Alahmar²,

Salem³

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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“…The role of TNF-α in DN has been verified in TNF-α(−/−) diabetic mice, which exhibited protection from SNCV and MNCV deficiency in contrast to normal mice. Based on various investigational studies, enhanced expressions of TNF-α and iNOS levels had an increased risk of developing DN [215,216]. In an in vitro research, treating rat microglia with more glucose boosted their mRNA expression of TNF-α and monocyte chemoattractant protein-1 (MCP-1), along with their production of these cytokines [217].…”

Section: Tnf-αmentioning

confidence: 99%

Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy

Ratan,

Rajput,

Pareek

et al. 2024

Biomedicines

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Diabetic neuropathy (DN) is a neurodegenerative disorder that is primarily characterized by distal sensory loss, reduced mobility, and foot ulcers that may potentially lead to amputation. The multifaceted etiology of DN is linked to a range of inflammatory, vascular, metabolic, and other neurodegenerative factors. Chronic inflammation, endothelial dysfunction, and oxidative stress are the three basic biological changes that contribute to the development of DN. Although our understanding of the intricacies of DN has advanced significantly over the past decade, the distinctive mechanisms underlying the condition are still poorly understood, which may be the reason behind the lack of an effective treatment and cure for DN. The present study delivers a comprehensive understanding and highlights the potential role of the several pathways and molecular mechanisms underlying the etiopathogenesis of DN. Moreover, Schwann cells and satellite glial cells, as integral factors in the pathogenesis of DN, have been enlightened. This work will motivate allied research disciplines to gain a better understanding and analysis of the current state of the biomolecular mechanisms behind the pathogenesis of DN, which will be essential to effectively address every facet of DN, from prevention to treatment.

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TNF-α levels, hypertension, glycated hemoglobin, and lower limb pain are predictors of diabetic neuropathy

Lima

Stival²,

Funghetto³

et al. 2023

Int J Diabetes Dev Ctries

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Tumor necrosis factor-α is a novel biomarker for peripheral neuropathy in type II diabetes mellitus: a clinical and electrophysiological study

Cited by 5 publications

References 36 publications

Tumor necrosis factor alpha in peripheral neuropathy in type 2 diabetes mellitus

Tumor necrosis factor alpha in peripheral neuropathy in type 2 diabetes mellitus

Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy

TNF-α levels, hypertension, glycated hemoglobin, and lower limb pain are predictors of diabetic neuropathy

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