“…In addition to its acid-suppressing effects, lansoprazole have been shown to modulate the inflammatory status, reduce oxidative stress, and ameliorate mucosal injuries in the esophagus [23,24], intestine [25,26], and lung [27], in addition to the stomach [28,29]. It has been also demonstrated by in vitro studies that lansoprazole inhibits the increased expression of vascular adhesion molecules, the activation of neutrophils, and the production of pro-inflammatory cytokines from activated endothelial cells [30,31]. We recently demonstrated using in vivo models that lansoprazole inhibits acute inflammatory reactions as well as intestinal mucosal injuries induced by ischemia-reperfusion [25] or indomethacin administration in rats [26].…”