Tumor Necrosis Factor-α Gene Polymorphism Relationship to Seminal Variables in Infertile Men

Zalata, Adel; Atwa, Ahmed; Badawy, Abd El-Naser; Aziz, Ahmed Abdel; Elbaz, Rizk; Elhanbly, Samir; Mostafa, Taymour

doi:10.1016/j.urology.2013.01.026

Cited by 21 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…substitution level from G to A in the TNF-α gene was significantly higher in the infertile subjects as compared to fertile controls 18 . Likewise, Egyptian population report by Zalata et al documented significant overrepresentation of TNF -308AA carriers among patients diagnosed with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia 19 . The latter study revealed also that TNF-α -308AA genotype was significantly associated with decreased sperm count, sperm motility, normal sperm morphology in the above mentioned groups of infertile patients.…”

Section: Discussionmentioning

confidence: 88%

TGFβ3 (TGFB3) polymorphism is associated with male infertility

Droździk

Kaczmarek

Malinowski

et al. 2015

Sci Rep

View full text Add to dashboard Cite

Factors affecting the blood-testis barrier function may be involved in testicular damage and male infertility. Two cytokines play an important role in the barrier regulation, namely transforming growth factor beta 3 (TGF-β3) and tumor necrosis factor (TNF-α). The aim of this study was to investigate the potential association between TGF-β3 (TGFB3) and TNF-α (TNF) gene polymorphisms and male infertility. A total of 846 subjects, 423 diagnosed with male infertility and 423 fertile men were enrolled. TGFB3 (rs2268626:T > C, rs3917158:C > T, rs2284792:A > G, rs2268625:T > C, rs3917187:C > T) and TNF (rs1800629:-308G > A) gene polymorphisms were genotyped. No association between TNF genotype and infertility was observed. As for TGFB3, the genotypes distribution was similar in infertile and fertile men. However, rs2284792 minor allele frequency was significantly higher among infertile subjects. Heterozygous rs2284792 AG genotype was associated with increased odds for infertility [OR = 1.40 (95% CI 1.05–1.86), p = 0.021] and similar results were observed for G allele carrier status [OR = 1.40 (95% CI 1.06–1.84), p = 0.017]. Heterozygosity in TGFB3 rs3917158 was also associated with the infertility [OR = 1.37 (95% CI 1.01–1.87), p = 0.041]. The TGFB3 variant genotypes were associated with lower spermatozoa motility parameters in fertile men. The results indicate that variants in TGFB3 gene may be associated with male infertility. However, the findings require further replication and validation.

show abstract

Section: Discussionmentioning

confidence: 88%

TGFβ3 (TGFB3) polymorphism is associated with male infertility

Droździk

Kaczmarek

Malinowski

et al. 2015

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Disruption of the blood-testis barrier by the inflammatory cytokines TNF-α and interleukin-6 have been found to significantly reduce sperm motility [1112]. Another study revealed that TNF-α was significantly associated with decreased sperm count, sperm motility, and normal sperm morphology among infertile patients [13]. While these inflammatory markers may improve our understanding of infertility, the technical difficulties and costs associated with measuring them in routine clinical practice limit their use.…”

Section: Discussionmentioning

confidence: 99%

Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio?

Aykan

Canat

Gönültaş

et al. 2017

World J Mens Health

View full text Add to dashboard Cite

PurposeThe aim of this study was to evaluate the relationship of seminal parameters with the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), which are inflammatory markers, in men with an abnormal semen analysis and men with normozoospermia.Materials and MethodsFifty-seven men with abnormal semen analyses and 59 men with normozoospermia were included in this cross-sectional study. A complete blood count was recorded, and the NLR and PLR were calculated from the hematologic parameters.ResultsThe NLR was 1.84±0.78 in the normozoospermic group and 1.80±0.75 in the abnormal semen analysis group. The PLR was 95.32±35.47 in the normozoospermic group and 93.57±28.09 in the abnormal semen analysis group. No significant differences were found between the normozoospermic and the abnormal semen analysis group in the NLR (p=0.828) or the PLR (p=0.768). In addition, no seminal parameters were correlated with the NLR or the PLR (p>0.05).ConclusionsWe do not recommend using the NLR or the PLR as markers to screen for abnormal semen parameters or male infertility.

show abstract

“…[14,15] İnfertil hastalarda yapılan başka bir çalışmada da TNF-α'nın sperm sayı, motilite ve morfolojisinde belirgin azalma ile ilişkili olabileceği ileri sürülmüştür. [16] Bu çalışmalarla inflamasyonun sperm parametreleri üzerinde olumsuz etkileri olduğu ortaya konsa da inflamatuar sitokinlerin semende değerlendirilmesinin teknik zorlukları ve yüksek maliyeti bu incelemelerin klinik pratikte kullanımını sınırlandırmıştır. Bu nedenle daha ucuz ve hızlı değerlendirilebilen inflamasyon belirteçleri olan NLR, PLR ve MER değerlerinin sperm parametreleri ile ilişkisinin incelenmesi gündeme gelmiştir.…”

Section: Sonuçunclassified

İnfertil erkeklerde seminal parametreler ile inflamasyon belirteçleri (Nötrofil-lenfosit, plateletlenfosit ve monosit-eozinofil oranları) ve serum vitamin D düzeyleri arasında ilişki yoktur

Küçükdurmaz¹,

Doğan²,

Olmez³

et al. 2019

Androl Bul

View full text Add to dashboard Cite

OBJECTIVES: Several hematological parameters are being investigated as useful prognostic markers based on host-related systemic inflammatory response. Although they are used to predict prognosis of patients in many conditions including various cancer types and inflammatory diseases, little is known about their prognostic efficacy in male infertility. Therefore, the aim of this study was to evaluate the relationship of seminal parameters with the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR) and monocyte-to-eosinophil (MER) ratio, which are inflammatory markers, in men with an abnormal semen analysis, and men with normozoospermia. We also investigated the correlation between vitamin D levels and seminal parameters. MATERIAL and METHODS: One hundred and twenty-six men with abnormal semen analyses and 79 men with normozoospermia were included in this cross-sectional study. A complete blood count was recorded, and the NLR, PLR and MER were calculated from the hematologic parameters. Vitamin D levels were also noted for participants. RESULTS: The NLR was 1.80±0.65 in the normozoospermic group and 1.82±0.66 in the abnormal semen analysis group. The PLR was 104.28±30.55 in the normozoospermic group and 106.73±35.01 in the abnormal semen analysis group. MER was 2.99±1.74 in normozoospermic men and 7.24±16.57 in abnormal semen analysis group. No significant differences were found between the normozoospermic and the abnormal semen analysis group in the NLR (p=0.911), the PLR (p=0.746) or MER (0.166). Vitamin D levels were also nonsignificant between two groups (37.62±1.91 vs. 38.43±2.51, p=0.103). In addition, no seminal parameters were correlated with the NLR, PLR or MER (p>0.05). CONCLUSION: According to our results, it is not possible to recommend using the NLR, PLR or MER as markers to screen for abnormal semen parameters or male infertility.

show abstract

Tumor Necrosis Factor-α Gene Polymorphism Relationship to Seminal Variables in Infertile Men

Cited by 21 publications

References 21 publications

TGFβ3 (TGFB3) polymorphism is associated with male infertility

TGFβ3 (TGFB3) polymorphism is associated with male infertility

Are There Relationships between Seminal Parameters and the Neutrophil-to-Lymphocyte Ratio or the Platelet-to-Lymphocyte Ratio?

İnfertil erkeklerde seminal parametreler ile inflamasyon belirteçleri (Nötrofil-lenfosit, plateletlenfosit ve monosit-eozinofil oranları) ve serum vitamin D düzeyleri arasında ilişki yoktur

Contact Info

Product

Resources

About