Tumor Necrosis Factor α-Dependent Neutrophil Priming Prevents Intestinal Ischemia/Reperfusion-Induced Bacterial Translocation

Abstract

TNFα-primed neutrophils by HPC act as effectors cells for enhancing barrier integrity under gut ischemia.

Hypoxia‐induced intestinal barrier changes in balloon‐assisted enteroscopy

“…; Lu et al . ). Physical compression of gut tissue may lead to temporary lack of vascular blood flow that reduces the delivery of oxygen to tissues.…”

“…; Lu et al . , ). Whether short‐ or long‐term hypoxia by balloon distension in BAE elicits differential barrier‐modulating effects in intestinal epithelium remains elusive.…”

“…The mucosal barrier plays a pivotal role in shielding the body proper against the influx of intestinal bacteria and microbial antigens. The loss of barrier integrity results in translocation of bacteria to systemic bloodstream and aseptic viscera, predisposing the host to septic complications and systemic inflammatory syndrome Lu et al 2017). Physical compression of gut tissue may lead to temporary lack of vascular blood flow that reduces the delivery of oxygen to tissues.…”

“…Paradoxically, protective effects in tissues and cells have also been found after intermittent hypoxia. Hypoxic preconditioning ameliorated the histopathological injury caused by subsequent ischaemia in various organs (Ahmad et al 2003;Liu et al 2005;Bernhardt et al 2006;Lu et al 2012Lu et al , 2017. Whether short-or long-term hypoxia by balloon distension in BAE elicits differential barrier-modulating effects in intestinal epithelium remains elusive.…”

Estudo da interação dos hormônios sexuais femininos na inflamação local, sistêmica e pulmonar causada pela isquemia e reperfusão intestinal em camundongos fêmeas obesas.

“…Há relatos que tais eventos provoquem lesão da barreira intestinal (LU et al, 2017) É importante salientar que estudos clínicos e experimentais relatam que danos causados pela IR intestinal levam a alterações no pulmão .…”