Tumor necrosis factor α (−308), interleukin-6 (−174) and interleukin-10 (−1082) gene polymorphisms in polycystic ovary syndrome

Vural, Pervin; Değirmencioğlu, Sevgin; Saral, Neslihan Yıldırım; Akgül, Cemil

doi:10.1016/j.ejogrb.2010.02.010

Cited by 64 publications

(78 citation statements)

References 31 publications

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“…Eight publications were excluded for insufficient or uncorrelated data according to our inclusion criteria [9,11,10,14,13,23,24,30]. Finally, 18 articles met the inclusion criteria and were selected [8,7,27,12,28,18,15,17,20,19,22,21,25,26,29,31,16]. The study selection process is shown in Fig.…”

Section: Search Resultsmentioning

confidence: 99%

“…The etiology involves multiple genetic and epigenetic alterations that are still indistinct, but the imbalance between pro-and antiinflammatory cytokines and polymorphisms in cytokine genes may play roles in the etiology of PCOS [17]. Identification of crucial genetic markers such as inflammation-related genes could help clarify the pathogenesis of PCOS.…”

Section: Discussionmentioning

confidence: 99%

“…For -308G>A, 582 PCOS cases and 563 controls from 4 articles [32,31,17,27] were included. For -805C>T, 87 cases and 115 controls were analyzed from the study by Korhonen [29].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…For the IL-1B +3953C>T polymorphism (rs1143634) in exon 5, 223 cases and 188 controls from 2 studies were included [18,25]. For IL-6 -174G>C (rs1800795), 416 cases and 569 controls from 5 studies were analyzed [7,17,19,21,26]. For IL-10 -819C> T polymorphism (rs1800871) we looked at 91 cases and 75 controls from 1 article [22], and we included 188 cases and 170 cases from 2 studies for the IL-10 -1082A>G polymorphism (rs1800896) [17,22].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…For IL-6 -174G>C (rs1800795), 416 cases and 569 controls from 5 studies were analyzed [7,17,19,21,26]. For IL-10 -819C> T polymorphism (rs1800871) we looked at 91 cases and 75 controls from 1 article [22], and we included 188 cases and 170 cases from 2 studies for the IL-10 -1082A>G polymorphism (rs1800896) [17,22]. For the IL-18 -607C>A polymorphism (rs1946518), we analyzed 118 cases and 79 controls from 1 study [15], and for IL-18 -137G>C (rs187238), we included 244 cases and 192 controls from 2 studies [12,15].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Associations between TNF-α and interleukin gene polymorphisms with polycystic ovary syndrome risk: a systematic review and meta-analysis

Yang

2015

J Assist Reprod Genet

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Background The associations between TNF-α and Interleukin gene polymorphisms and polycystic ovary syndrome (PCOS) risk have been studied in numerous epidemiological studies, but the results remain controversial. To investigate whether these polymorphisms facilitate susceptibility to PCOS, we conducted a comprehensive systematic review and meta-analysis. Methods PubMed, Embase, Web of Science, Medline, CNKI, and Google Scholar were searched to obtain the genetic association studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Odds ratios (OR) with corresponding 95 % confidence intervals (CI) were used to assess the strengths of the associations. Funnel plots and Egger's tests were performed to test for possible publication bias. All statistical analyses were performed using Review No associations were found with the other genetic models. Conclusion The results of the meta-analysis suggest positive associations between the TNF-α -1031 T> C and IL-6 -174G>C polymorphisms and the risk of PCOS. No associations are found between PCOS risk and the TNF-α -308G>A, TNF-α -805C>T, IL-1A -889C>T, IL-1B -511C>T, IL-1B + 3953C>T, IL-10 -819C>T, IL-10 -1082 A>G, IL-18 -607C> A, and IL-18 -137G>C polymorphisms. However, due to the heterogeneity and low quality of the studies related to PCOS polymorphisms in the meta-analysis, the results should be interpreted with caution. Future multi-ethnicity studies of homogeneous populations of PCOS patients with larger sample sizes and well-matched controls are needed.

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Section: Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…For -308G>A, 582 PCOS cases and 563 controls from 4 articles [32,31,17,27] were included. For -805C>T, 87 cases and 115 controls were analyzed from the study by Korhonen [29].…”

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Associations between TNF-α and interleukin gene polymorphisms with polycystic ovary syndrome risk: a systematic review and meta-analysis

Yang

2015

J Assist Reprod Genet

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Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update

Gnanadass

Prabhu

Gopalakrishnan

2021

Arch Gynecol Obstet

141

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Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women

Zhang

Xia

et al. 2012

Mol Biol Rep

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The cholesterol side chain cleavage enzyme (CYP11A1) gene plays an important part in the synthesis of sex hormones and has been reported to be involved in the pathogenesis of polycystic ovary syndrome. A case-control study including 314 PCOS patients and 314 controls was conducted to assess the association of the SNPs rs4077582 and rs11632698 in CYP11A1 with PCOS using the polymerase chain reaction-restriction fragment length polymorphism method. Thereafter, 100 DNA samples were re-genotyped by direct sequencing for confirmation. The genotypic distribution of rs4077582 in women with PCOS differed from that in controls (P = 0.002). No such distributional difference was found in rs11632698 (P = 0.912). Data from our previous study of these two SNPs in another population including 290 PCOS patients and 344 controls was combined with the current data. Combined analysis (a total of 1262 participants, including 604 PCOS patients and 658 control women) showed a much more significant difference in the genotypic distribution of rs4077582 between PCOS and controls (P < 0.001). The T allele was more prevalent in PCOS patients (Odds ratio = 1.314; 95 % CI 1.122-1.540). The testosterone levels among the three genotypes for rs4077582 were different in the control group, as were the LH levels and the LH/FSH ratio. Therefore, SNP rs4077582 in CYP11A1 is strongly associated with susceptibility to PCOS and may alter the testosterone levels by the regulation of LH in different genotypes. No association was observed in rs11632698.

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Tumor necrosis factor α (−308), interleukin-6 (−174) and interleukin-10 (−1082) gene polymorphisms in polycystic ovary syndrome

Cited by 64 publications

References 31 publications

Associations between TNF-α and interleukin gene polymorphisms with polycystic ovary syndrome risk: a systematic review and meta-analysis

Associations between TNF-α and interleukin gene polymorphisms with polycystic ovary syndrome risk: a systematic review and meta-analysis

Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update

Association between polymorphisms of the CYP11A1 gene and polycystic ovary syndrome in Chinese women

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