Tumor Necrosis Factor (TNF) –308G&gt;A, Nitric Oxide Synthase 3 (NOS3) +894G&gt;T Polymorphisms and Migraine Risk: A Meta-Analysis

Chen, Min; Tang, Wenjing; Hou, Lei; Liu, Ruozhuo; Dong, Zhao; Han, Xun; Zhang, Xiaofei; Wan, Dongjun; Yu, Shengyuan

doi:10.1371/journal.pone.0129372

Cited by 16 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 10) There is a relationship between the presences of the gene NOS3 Single-nucleotide polymorphism T-786 (SNP T-786) with the occurrence of preeclampsia. (14) This could be elucidated if a further study was done in this study subjects to examine the association between NOS3 gene/ polymorphism of the NOS3 gene, NOS3 enzyme level, L-citrulline level, and blood pressure. If those studies were also proven to be wrong, it could be concluded that the main etiopathogenesis of preeclampsia in this study subjects was not due to vascular factor.…”

Section: Discussionmentioning

confidence: 96%

The Correlation of L-citrulline Levels with Blood Pressure in Severe Preeclampsia

et al. 2020

View full text Add to dashboard Cite

BACKGROUND: Based on 'vascular disorder of pregnancy' terminology, preeclampsia primarily was not a hypertensive disorder, but a vascular disorder (general vasospasm) in pregnancy due to idiopathic etiology. The overall incidence of preeclampsia was 5-14% of all pregnancies. One of the substances responsible for regulating vascular tone is nitric oxide (NO), which produced in endothelial blood vessels. NO and L-citrulline are produced altogether by the reaction between L-arginine and oxygen. L-citrulline levels reflected NO production. This study was aimed to assess the correlation between the L-citrulline level and blood pressure in severe preeclampsia.METHODS: This cross-sectional study was done in Dr. M. Djamil Central General Hospital, Padang, Indonesia The sample size was 36 samples of pregnant women with severe preeclampsia and had yet been given antihypertensive therapy. Sampling was done by consecutive sampling from Obstetrics and Gynecology Division. After maternal examination and measurements L-citrulline levels of cubital venous blood by using enzyme-linked immunosorbent assay (ELISA) method, Pearson correlation was performed to assess the relationship between variables for normally distributed data and Spearman's correlation for abnormal distribution data with significance level p<0.05.RESULTS: Means of L-citrulline levels, systolic blood pressure, diastolic blood pressure, and arterial pressure (MAP) were 87.21 nmol/mL, 179.4 mmHg, 108.3mmHg, and 132.1 mmHg, respectively. Correlation of the L-citrulline level with systolic blood pressure, diastolic blood pressure, and MAP were -0.08, -0.175, and -0.136 (p>0.05), respectively.CONCLUSION: L-citrulline levels had no correlation with blood pressure in severe preeclampsia.KEYWORDS: L-citrulline levels, blood pressure, severe preeclampsia

show abstract

Section: Discussionmentioning

confidence: 96%

The Correlation of L-citrulline Levels with Blood Pressure in Severe Preeclampsia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Despite denying an overall association between this polymorphism and migraine risk, subgroup analyses demonstrated, in line with previous results, that the ‘A’ allele of the TNF -308G>A variant increases the risk of migraine among non-Caucasians (pooled OR = 1.82). Moreover, the risk for MA was slightly increased among both Caucasians and non-Caucasians [ 43 ].…”

Section: Genetic Findings Related To the Immune System In Migraineursmentioning

confidence: 99%

Immunological findings in patients with migraine and other primary headaches: a narrative review

Biscetti

Vanna

Cresta

et al. 2021

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Experimental findings suggest an involvement of neuroinflammatory mechanisms in the pathophysiology of migraine. Specifically, preclinical models of migraine have emphasized the role of neuroinflammation following the activation of the trigeminal pathway at several peripheral and central sites including dural vessels, the trigeminal ganglion and the trigeminal nucleus caudalis. The evidence of an induction of inflammatory events in migraine pathophysiological mechanisms has prompted researchers to investigate the Human leukocyte antigen (HLA) phenotypes as well as cytokine genetic polymorphisms in order to verify their potential relationship with migraine risk and severity. Furthermore, the role of neuroinflammation in migraine seems to be supported by evidence of an increase in pro-inflammatory cytokines, both ictally and interictally, together with the prevalence of Th1 lymphocytes and a reduction in regulatory lymphocyte subsets in peripheral blood of migraineurs. Cytokine profiles of cluster headache patients and those of tension-type headache patients further suggest an immunological dysregulation in the pathophysiology of these primary headaches, although evidence is weaker than for migraine. The present review summarizes available findings to date from genetic and biomarker studies that have explored the role of inflammation in primary headaches.

show abstract

“…[ 16 ] A recent meta-analysis indicated that “T” allele of the eNOS +894G > T variant increased the risk of migraine among non-Caucasians. [ 17 ] The substitution of thymine by cytosine in the 5′ promoter region at nucleotide—786 (−786T>C) results in a significant reduction in eNOS gene promoter activity and in decreased basal NO production. [ 16 ] Similarly, there are some controversies for the connection between eNOS polymorphism (−786T>C) and migraine risk.…”

Section: Introductionmentioning

confidence: 99%

Endothelial nitric oxide synthase (−786T>C) polymorphism and migraine susceptibility

Han

Wang²,

Dong³

et al. 2018

Medicine

View full text Add to dashboard Cite

Background:The aim of this study was to evaluate the correlation between endothelial nitric oxide synthase (eNOS) polymorphism (−786T>C) and migraine susceptibility in a meta-analysis.Methods:A literature search was performed for case–control studies from inception to July 30, 2018 focusing on eNOS polymorphism (−786T>C) and risk of migraine. From 454 full-text articles, 6 were included in this study. Heterogeneity was assessed with the I2 index and quality assessment was performed using the Newcastle–Ottawa scale.Results:CC genotype was not related to higher susceptibility of migraine compared with TT+ TC genotypes with significant difference (fixed effects model; OR = 1.27; 95% CI = 0.90–1.80; P = .17; I2 = 18%). However, subgroup analysis showed CC variant increase the risk for migraine compared with TT+ TC genotypes in Caucasian populations (fixed effects model; OR = 1.62; 95% CI = 1.03–2.56; P = .04; I2 = 18%), which could not be observed in non-Caucasian populations (fixed effects model; OR = 0.88; 95% CI = 0.51–1.53; P = .66; I2 = 0%). There was no significant difference for other genotypes and alleles between patients with migraine and healthy controls (all P > .05).Conclusion:This meta-analysis indicated that CC variant increases the risk for migraine compared with TT + TC genotypes in Caucasian populations.

show abstract

Tumor Necrosis Factor (TNF) –308G>A, Nitric Oxide Synthase 3 (NOS3) +894G>T Polymorphisms and Migraine Risk: A Meta-Analysis

Cited by 16 publications

References 55 publications

The Correlation of L-citrulline Levels with Blood Pressure in Severe Preeclampsia

The Correlation of L-citrulline Levels with Blood Pressure in Severe Preeclampsia

Immunological findings in patients with migraine and other primary headaches: a narrative review

Endothelial nitric oxide synthase (−786T>C) polymorphism and migraine susceptibility

Contact Info

Product

Resources

About