Tumor Necrosis Factor-   Regulates the Gene Expression of Macrophage Migration Inhibitory Factor through Tyrosine Kinase-Dependent Pathway in 3T3-L1 Adipocytes

Hirokawa, Jun; Sakaue, Shinji; Furuya, Yukiko; Ishii, Jun; Hasegawa, Atsushi; Tagami, Seiichi; Kawakami, Yoshikazu; Sakai, Masaharu; Nishi, Shinzo; Nishihira, Jun

doi:10.1093/oxfordjournals.jbchem.a021998

Cited by 56 publications

(32 citation statements)

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“…Study of MIF knockout mice suggests that MIF is required for normal function of macrophage (43). MIF is produced by many types of cells, including adipocytes, monocytes/macrophages, and lymphocytes (19,49). In human adipocytes, MIF expression is positively associated with patient body mass index and negatively correlated with insulin sensitivity (49,58).…”

Section: Discussionmentioning

confidence: 99%

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue ofob/oband dietary obese mice

Ye¹,

Gao²,

Yin³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

735

727

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Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293: E1118-E1128, 2007. First published July 31, 2007; doi:10.1152/ajpendo.00435.2007.-Chronic inflammation and reduced adiponectin are widely observed in the white adipose tissue in obesity. However, the cause of the changes remains to be identified. In this study, we provide experimental evidence that hypoxia occurs in adipose tissue in obese mice and that adipose hypoxia may contribute to the endocrine alterations. The adipose hypoxia was demonstrated by a reduction in the interstitial partial oxygen pressure (PO2), an increase in the hypoxia probe signal, and an elevation in expression of the hypoxia response genes in ob/ob mice. The adipose hypoxia was confirmed in dietary obese mice by expression of hypoxia response genes. In the adipose tissue, hypoxia was associated with an increased expression of inflammatory genes and decreased expression of adiponectin. In dietary obese mice, reduction in body weight by calorie restriction was associated with an improvement of oxygenation and a reduction in inflammation. In cell culture, inflammatory cytokines were induced by hypoxia in primary adipocytes and primary macrophages of lean mice. The transcription factor NF-B and the TNF-␣ gene promoter were activated by hypoxia in 3T3-L1 adipocytes and NIH3T3 fibroblasts. In addition, adiponectin expression was reduced by hypoxia, and the reduction was observed in the gene promoter in adipocytes. These data suggest a potential role of hypoxia in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissue in obesity.partial oxygen pressure; obesity; type 2 diabetes; insulin resistance IN OBESITY, chronic inflammation and reduced adiponectin in the white adipose tissue (WAT) contribute to pathogenesis of insulin resistance, which links obesity to many complications, such as type 2 diabetes and cardiovascular diseases (23,24,30). The chronic inflammation is indicated by an increased expression of proinflammatory cytokines and elevated infiltration of macrophages into adipose tissue. Of the proinflammatory cytokines, TNF-␣ and IL-6 reduce insulin sensitivity and impair the homeostasis of lipid and glucose metabolism. Monocyte chemoattractant protein-1 (MCP-1) promotes macrophage infiltration into adipose tissue. Although expression of these cytokines is increased in adipose tissue of obese subjects, it is not clear what induces expression of these inflammatory cytokines in obesity. A decrease in adiponectin (ACRP30) production contributes to pathogenesis of insulin resistance (23). However, it remains to be investigated what obesityassociated factor leads to suppression of adiponectin.Systemic hypoxia is associated with insulin resistance in human and animal. In patients with obstructive sleep apnea or sleep-disordered breathing, intermittent hypoxia is associated with a high risk for insulin resistance (...

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Section: Discussionmentioning

confidence: 99%

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue ofob/oband dietary obese mice

Ye¹,

Gao²,

Yin³

et al. 2007

American Journal of Physiology-Endocrinology and Metabolism

735

727

View full text Add to dashboard Cite

show abstract

“…Thus, a diminished total antioxidant capacity could reflect an increased antioxidant uptake by immune cells in order to help neutralize the increasing expression of adhesion molecules and other oxidative-stress-related events. In addition, higher TNF-a levels may contribute to impaired chemotactic function since this cytokine has been shown to induce the expression of macrophage-migration-inhibitory factor [37].…”

Section: Discussionmentioning

confidence: 99%

Impairment of several immune functions in anxious women

Arranz

Guayerbas

Fuente

2007

Journal of Psychosomatic Research

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“…TNF-α induces the expression of MIF in adipocytes. 84,85 Conversely, MIF leads to the killing of Leishmania major by macrophages through the induction of TNF-α and reactive oxygen intermediates. 86 This effect of MIF is inhibited by the Th-2 related cytokines, IL-10 and IL-13.…”

Section: Th-1 and Th-2 Responses In Malariamentioning

confidence: 99%

Major Hematologic Diseases in the Developing World— New Aspects of Diagnosis and Management of Thalassemia, Malarial Anemia, and Acute Leukemia

Greenberg¹,

Issaragrisil²,

Siritanaratkul³

et al. 2001

Hematology

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The three presentations in this session encompass clinical, pathophysiological and therapeutic aspects of hematologic diseases which impact most heavily on developing world countries. Dr. Victor Gordeuk discusses new insights regarding the multi-faceted pathogenesis of anemia in the complicated malaria occurring in Africa. He describes recent investigations indicating the possible contribution of immune dysregulation to this serious complication and the implications of these findings for disease management. Dr. Surapol Issaragrisil and colleagues describe epidemiologic and clinical characteristics of the thalassemic syndromes. In addition to being considered a major health problem in Southeast Asia, the migration throughout the world of people from this region has caused the disease to have global impact. A unique thalassemia variant, Hb Eβ-thalassemia, with distinctive clinical features, has particular relevance for this demographic issue. Special focus will be reported regarding recent prenatal molecular screening methods in Thailand which have proven useful for early disease detection and disease control strategies. Dr. Raul Ribeiro describes a clinical model for providing effective treatment for a complex malignancy (childhood acute lymphoblastic leukemia) in countries with limited resources. With the multidisciplinary approach in Central American of the joint venture between St. Jude Children's Research Hospital International Outreach Program and indigenous health care personnel, major therapeutic advances for this disease have been achieved. Given the major demographic population shifts occurring worldwide, these illnesses also have important clinical implications globally. These contributions demonstrate that lessons learned within countries of disease prevalence aid our understanding and management of a number of disorders prominently seen in developed countries. They will show how effective partnerships between hematologists in more and less developed nations may work together to produce important advances for treating major hematologic diseases in less developed regions. A major focus relates to the socio-economic and medical burden of these diseases in developing countries with limited resources. As such, these problems provide a challenge and an opportunity for collaborative interaction between hematologists and policy makers worldwide.

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Tumor Necrosis Factor- Regulates the Gene Expression of Macrophage Migration Inhibitory Factor through Tyrosine Kinase-Dependent Pathway in 3T3-L1 Adipocytes

Cited by 56 publications

References 0 publications

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue ofob/oband dietary obese mice

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue ofob/oband dietary obese mice

Impairment of several immune functions in anxious women

Major Hematologic Diseases in the Developing World— New Aspects of Diagnosis and Management of Thalassemia, Malarial Anemia, and Acute Leukemia

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