Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Dürr, Claudia; Hanna, Bola S.; Schulz, Angela; Lucas, Fabienne; Zucknick, Manuela; Benner, Axel; Clear, Andrew; Öhl, S.; Öztürk, Selcen; Zenz, Thorsten; Stilgenbauer, Stephan; Li‐Weber, Min; Krammer, Peter H.; Gribben, John G.; Lichter, Peter; Seiffert, Martina

doi:10.3324/haematol.2017.177808

Cited by 29 publications

(30 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2) is a plant flavonoid extracted from roots of Scutellaria baicalensis, Scutellaria amoena and Scutellaria rivularis, and stem of Anodendron affine Druce, and has many pharmacological effects including anti-viral, anti-oxidative, anti-inflammatory, anti-cancer and neuroprotective activities [702][703][704][705]. It has various anti-cancer effects in many cancers, including lung, breast, head and neck, gastric and colorectal cancers, glioma, leukemia, lymphoma, and osteosarcoma, through the induction of apoptosis and cell cycle arrest, and inhibition of cell growth, migration, invasion, and angiogenesis [706][707][708][709][710][711][712][713][714][715][716].…”

Section: Wogoninmentioning

confidence: 99%

See 1 more Smart Citation

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

View full text Add to dashboard Cite

Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

show abstract

Section: Wogoninmentioning

confidence: 99%

“…Moreover, immunization with wogonintreated tumor cell vaccine effectively inhibits tumor growth in MFC xenograft mice [732]. Targeting TNF receptor with wogonin is also suggested to be a potential strategy for the treatment of chronic lymphocytic leukemia [712].…”

Section: Wogoninmentioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The treatment of leukemia caused a reduced expression of TNF R-1 on B-CLL cells and their passage to blood. Affecting TNF R-1 signaling is an interesting option for B-CLL therapy [219].…”

Section: Future Perspectivesmentioning

confidence: 99%

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Allegra

Musolino

Tonacci

et al. 2020

Cancers

View full text Add to dashboard Cite

B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate immune elements and adaptive immune factors are interconnected in B-CLL and are decisive for its onset, evolution, and therapeutic response. Modifications in the cytokine balance could support the growth of the leukemic clone via a modulation of cellular proliferation and apoptosis, as some cytokines have been reported to be able to affect the life of B-CLL cells in vivo. In this review, we will examine the role played by cytokines in the cellular dynamics of B-CLL patients, interpret the contradictions sometimes present in the literature regarding their action, and evaluate the possibility of manipulating their production in order to intervene in the natural history of the disease.

show abstract

“…59 In vivo studies have shown that wogonin has a significant inhibitory effect on early chronic lymphoid leukemia, mouse gastric cancer xenografts, and gliomas. 35,59,109 Apigenin (Fig. 1), is a bioavailable flavonoid, derived from a variety of fruits, vegetables, and drinks.…”

Section: Resveratrolmentioning

confidence: 99%

“…Most polyphenols contribute to pharmacologic activities, such as anti‐inflammatory, immunemodulatory, and anticancer actions 30,31 . For instance, curcumin, 32 resveratrol, 33 apigenin, 34 wogonin, 35 epigallocatechin‐3‐gallate, 36 and icariin 37 have demonstrated efficacy as anticancer compounds. Polyphenols are commonly found in vegetables, fruits, and cereals as glycoside esters or free aglycones; they are mainly classified into two groups: nonflavonoids and flavonoids 38 …”

Section: Molecular Mechanisms On Natural Products In Tumor Immunotherapymentioning

confidence: 99%

Natural products and their derivatives: Promising modulators of tumor immunotherapy

Deng

et al. 2020

Journal of Leukocyte Biology

138

View full text Add to dashboard Cite

A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid-derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF-B, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research.

show abstract

Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin

Cited by 29 publications

References 52 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Natural products and their derivatives: Promising modulators of tumor immunotherapy

Contact Info

Product

Resources

About