Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in peroxinectin gene expression in Fenneropenaeus penicillatus

Cai, Shuanghu; Huang, Yucong; Wang, Bei; Jian, Jichang; Xu, Youhou

doi:10.1016/j.fsi.2017.03.026

Cited by 17 publications

(4 citation statements)

References 31 publications

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“…This may suggest that TRAF-6 may be a relay protein between the S. domuncula TLR and further signaling pathways since both the TLR and TRAF-6 genes expression evolved in the same way in the presence of LPS. This is in agreement with some recent results found in the literature concerning mammals [43,44,45] as well as marine invertebrates [46,47,48,49]. Furthermore, concerning the pathogenic bacterium, it seems that TRAF-6 gene expression is mainly affected in response to one/several secreted molecules or vesicles.…”

Section: Discussionsupporting

confidence: 92%

The Challenge of the Sponge Suberites domuncula (Olivi, 1792) in the Presence of a Symbiotic Bacterium and a Pathogen Bacterium

Pennec

Gardères

2019

Genes

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Sponges, which are in close contact with numerous bacteria in prey/predator, symbiotic and pathogenic relationships, must provide an appropriate response in such situations. This starts with a discriminating recognition of the partner either by a physical contact or through secreted molecules or both. We investigated the expression of the Toll-like receptor, Caspase 3/7, Tumor Necrosis Factor receptor-associated factor 6, Bcl-2 homology protein-2 and macrophage expressed genes of axenic sponge cells in the presence of a symbiotic bacterium (Endozoicomonas sp. Hex311), a pathogen bacterium (Pseudoalteromonas sp. 1A1), their exoproducts and lipopolysaccharides. The vast majority of answers are in line with what could be observed with the symbiotic bacterium. The pathogenic bacterium seems to profit from the eukaryotic cell: suppression of the production of the antibacterial compound, inhibition of the apoptosis caspase-dependent pathway, deregulation of bacterial recognition. This work contributes new scientific knowledge in the field of immunology and apoptosis in early branching metazoan harboring within its tissue and cells a large number of symbiotic bacteria.

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Section: Discussionsupporting

confidence: 92%

The Challenge of the Sponge Suberites domuncula (Olivi, 1792) in the Presence of a Symbiotic Bacterium and a Pathogen Bacterium

Pennec

Gardères

2019

Genes

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“…TRAF6 is a central signaling adapter protein that activates nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK), phosphoinositide 3-kinase (PI3K) and interferon regulatory factor pathways via its TRAF domain and a RING finger domain [ 30 ]. The role of TRAF6 in the antiviral response has been shown in two kinds of shrimp [ 31 , 32 ]. SOCS2 is an inhibitor of the JAK/STAT pathway that mediates antiviral immune response, and knockdown of SOCS2 could enhance resistance against pathogens in both Marsupenaeus japonicus and L. vannamei [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Different Immune Responses of the Lymphoid Organ in Shrimp at Early Challenge Stage of Vibrio parahaemolyticus and WSSV

Wang

2021

Animals

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The lymphoid organ is an essential part of the immune system involved in cellular and humoral immune responses in shrimp. However, its roles in the immune responses against different pathogens are still largely unclear. In the present study, transcriptomic analysis was applied to compare the differentially expressed genes (DEGs) in the lymphoid organ of shrimp after Vibrio or WSSV challenge. In total, 2127 DEGs were screened in the lymphoid organ of shrimp at 6 h post Vibrio parahaemolyticus injection, and 1569 DEGs were obtained at the same time after WSSV challenge. KEGG pathway enrichment analysis of these DEGs revealed that two significantly enriched pathways including “neuroactive ligand–receptor interaction” and “protein digestion and absorption” were responsive to both pathogens. In contrast, “lysosome” was the significantly enriched pathway only in Vibrio challenge whereas carbohydrate metabolism related pathways were the significantly enriched pathways only in WSSV challenge. Further analysis on immune-related DEGs showed that Vibrio challenge induced broad immune responses in the lymphoid organ including activation of several pattern recognition receptors, the proPO activating system, phagocytosis related genes, and immune effectors. In contrast, the immune responses seemed to be inhibited after WSSV infection. The data suggest that the shrimp lymphoid organ plays different functions in response to the infection of distinct pathogens at the early stage, which provides new insights into the immune functions of lymphoid organ in shrimp.

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“…TRAF6, one of the most evolutionarily ancient members of TRAF family, is ubiquitously expressed in various tissues and cell types (Cai et al, 2017;Jiang et al, 2017;Lalani et al, 2018). It contains a characteristic C-terminal TRAF domain, a similar N-terminal RING domain, followed by at least four zinc fingers (Hu et al, 2017;Fu et al, 2018).…”

Section: Traf6mentioning

confidence: 99%

“…TRAF4 is a unique member of the TRAF family, in terms of both structure and function. Firstly, TRAF4 is an ancestral member, due to the fact that other TRAFs members (except TRAF6) have evolved to a certain extent ( Cai et al, 2017 ). Secondly, TRAF4 is the only member that has three cysteine-rich motifs associated with TRAF and RING domains, followed by seven zinc fingers ( Rousseau et al, 2014 ; Yang et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Roles of TRAFs in Ischemia-Reperfusion Injury

Wei

Lin

Zhong

et al. 2020

Front. Cell Dev. Biol.

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Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAFdependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.

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Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in peroxinectin gene expression in Fenneropenaeus penicillatus

Cited by 17 publications

References 31 publications

The Challenge of the Sponge Suberites domuncula (Olivi, 1792) in the Presence of a Symbiotic Bacterium and a Pathogen Bacterium

The Challenge of the Sponge Suberites domuncula (Olivi, 1792) in the Presence of a Symbiotic Bacterium and a Pathogen Bacterium

Different Immune Responses of the Lymphoid Organ in Shrimp at Early Challenge Stage of Vibrio parahaemolyticus and WSSV

Roles of TRAFs in Ischemia-Reperfusion Injury

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