Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features

Mercado, Mónica Vázquez-Del; Navarro-Hernández, Rosa Elena; Torres-Carrillo, Norma; Martínez-Bonilla, Gloria; Estrada-Garcı́a, Iris; Rangel-Villalobos, Héctor; Muñoz‐Valle, José Francisco

doi:10.1007/s00296-006-0159-7

Cited by 19 publications

(14 citation statements)

References 25 publications

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“…However, the actions of TNF-α are mediated through binding to TNFR2. A genetic abnormality of cytokine regulation that may play a role in the pathophysiology of acne has been examined in a series of studies [16,17,28] , further exploring the TNFR2 gene polymorphisms which affect the production of inflammatory mediators. Peral's [16] results have suggested that the TNFR2 genotype may influence hyperandrogenism and PCOS, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.…”

Section: Discussionmentioning

confidence: 99%

“…The TNFR2 mediates most of the metabolic effects of TNF-α. Some studies have proposed that the M196R (676 T→G) variant in exon 6 of TNFR2 is associated with hyperandrogenism [16] , polycystic ovary syndrome (PCOS) [16] , rheumatoid arthritis and osteoarthritis [17] , and SLE [18] etc., further suggesting the role of inflammatory cytokines such as TNFR2 in the pathogenesis of the inflammation-and immune-related diseases.…”

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confidence: 99%

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TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: A case-control study

Tian

Xie

Yang

et al. 2010

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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In this case-control study, the relationship between M196R (676 T-->G) variant in exon 6 of tumor necrosis factor receptor type 2 (TNFR2) gene and genetic susceptibility of acne vulgaris in Han Chinese was investigated. A total of 93 acne vulgaris patients and 90 healthy subjects from Han Chinese ethnic group were enrolled in this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was adopted to analyze the single nucleotide polymorphisms (SNPs) of TNFR2 M196R gene, and to examine the association between acne vulgaris and the polymorphisms in TNFR2 M196R gene. The relationship between different genotypes and the susceptibility of acne vulgaris was analyzed. The results showed that there was significant difference in the frequency of the genotype M/R+R/R in the TNFR2 M196R genetic polymorphisms between acne vulgaris patients and healthy controls (chi2=4.343; P=0.037; OR=1.899; 95% CI: 1.036-3.445); and there was significant difference in the allele (R) frequency between acne vulgaris patients and healthy controls (chi2=5.588; P=0.018; OR=1.838; 95% CI: 1.105-3.057). It was concluded that the high frequency of 196R allele in the functional M196R polymorphism of TNFR2 is a risk factor for acne vulgaris in Han Chinese.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: A case-control study

Tian

Xie

Yang

et al. 2010

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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show abstract

“…However, the actions of TNF-α are mediated by binding to TNFR2. A genetic abnormality of TNFR2 regulation that may play a role in the pathophysiology of acne has been examined in a series of studies [16,17,28], further exploring the TNFR2 gene polymorphisms which affect the production of inflammatory mediators [16,17,57]. The results of Peral et al [16] suggest that the TNFR2 genotype may influence hyperandrogenism and polycystic ovary syndrome, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have proposed that the M196R (676 T→G) variant in exon 6 of TNFR2 is associated with e.g. hyperandrogenism [16], polycystic ovary syndrome [16], rheumatoid arthritis and osteoarthritis [17] or systemic lupus erythematosus [18], further suggesting the role of inflammatory cytokines such as TNFR2 in the pathogenesis of these disorders.…”

Section: Introductionmentioning

confidence: 99%

Association Study of Tumor Necrosis Factor Receptor Type 2 M196R and Toll-Like Receptor 2 Arg753Gln Polymorphisms with Acne Vulgaris in a Chinese Han Ethnic Group

Tian

Xie

Yang³

et al. 2010

Dermatology

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Background: Inflammatory cytokines such as tumor necrosis factor receptor 2 (TNFR2) and Toll-like receptor 2 (TLR2) are the main responsible mediators of inflammatory acne. Factors affecting their production may possibly influence the degree of inflammatory response and hence may account for the clinical severity of acne. However, the roles of TNFR2 and TLR2 in the pathophysiology of acne vulgaris are poorly understood. We therefore investigated the relationship between acne vulgaris susceptibility and the polymorphisms in the TNFR2 M196R as well as TLR2 Arg753Gln gene. Methods: A total of 93 acne vulgaris patients and 90 healthy subjects from the Chinese Han ethnic group were enrolled in the study. The polymerase chain reaction restriction fragment length polymorphism technique was adopted to analyze the single-nucleotide polymorphisms of the TNFR2 M196R and TLR2 Arg753Gln gene, and to examine the association between acne vulgaris and the polymorphisms in the TNFR2 M196R as well as TLR2 Arg753Gln gene. The relationship between different genotypes and the susceptibility to acne vulgaris was analyzed. Results: There is a significant difference in the frequency of TNFR2 M196R genetic polymorphisms between the moderate-acne to severe-acne subgroups and the control group (p < 0.05), and there is also a significant difference in the frequency of TLR2 Arg753Gln genetic polymorphisms between the severe-acne subgroup and control group (p < 0.05). Conclusion: The 196R allele of TNFR2 M196R as well as the 753Gln allele of TLR2 Arg753Gln are risk factors for acne vulgaris in Chinese Han patients, further supporting the contribution of inflammatory cytokines to the pathogenesis of acne.

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“…It was shown that single-nucleotide polymorphisms (SNP) or elevated plasma levels are associated to some degree with the risk and clinical outcome of some subtypes of lymphomas, solid tumors, and autoimmune diseases such as rheumatoid arthritis or allergy/asthma (16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Circulating Levels of TNF Receptor II Are Prognostic for Patients with Peripheral T-cell Non–Hodgkin Lymphoma

Heemann

Kreuz²,

Stoller³

et al. 2012

Clinical Cancer Research

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Purpose: Peripheral T-cell non–Hodgkin lymphomas (T-NHL) represent a small but heterogeneous and clinically aggressive subset of NHLs with a poor outcome. Cytokines or their receptors might be associated with the clinical outcome of these lymphomas. Therefore, we tested whether gene variations and serum levels of soluble TNF receptor (TNFR)I (sTNFRI), sTNFRII, interleukin (IL)-10, or sIL-4R are predictive for treatment response in T-NHLs. Experimental Design: Peripheral blood DNA from 117 patients with T-NHL treated in prospective clinical trials was subjected to genotyping analysis. Whenever possible, pretreatment sera were obtained, and circulating levels of sTNFRI, sTNFRII, IL-10, and sIL-4R were determined with a specific capture enzyme-linked immunoassay. Results: Patients characterized by TNFRI-609GG (rs4149570) showed a trend toward better event free survival [EFS; univariate: P = 0.041; multivariate: HR, 1.76; confidence interval (CI), 0.99–3.14 with P = 0.056]. A protective role of IL-10–1087A, −824T, and −597A reported in another study was not confirmed in our cohort. Patients with circulating levels of soluble TNFRII ≥2.16 ng/mL had a 2.07-fold increased relative risk for shorter overall survival (OS; univariate: P = 0.0034; multivariate: HR, 2.07; CI, 0.92–4.70 with P = 0.081) and a 2.49-fold higher risk for shorter EFS (univariate: P = 0.00068; multivariate: HR, 2.49; CI, 1.22–5.08 with P = 0.012). Elevations of circulating levels of sTNFRI, IL-10, and sIL-4R are frequent, but the clinical response in these patients is not significantly different. Conclusions: Our findings suggest a critical role for TNF-TNFR signaling for the clinical outcome of patients with peripheral T-NHLs. Clin Cancer Res; 18(13); 3637–47. ©2012 AACR.

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Tumor necrosis factor receptor 2 M196R polymorphism in rheumatoid arthritis and osteoarthritis: relationship with sTNFR2 levels and clinical features

Cited by 19 publications

References 25 publications

TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: A case-control study

TNFR 2 M196R polymorphism and acne vulgaris in Han Chinese: A case-control study

Association Study of Tumor Necrosis Factor Receptor Type 2 M196R and Toll-Like Receptor 2 Arg753Gln Polymorphisms with Acne Vulgaris in a Chinese Han Ethnic Group

Circulating Levels of TNF Receptor II Are Prognostic for Patients with Peripheral T-cell Non–Hodgkin Lymphoma

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