Tumor necrosis factor-like weak inducer of apoptosis expression in healthy oral mucosa, oral dysplasia and oral squamous cell carcinoma

Acharya, Swetha; Prabhu, Prashant; Patil, Vijay S.; Acharya, Anirudh B.; Desai, Anil Kumar; Nikhil, Krithi

doi:10.4103/jomfp.jomfp_151_19

Cited by 1 publication

(1 citation statement)

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“…TB in biopsy material is better defined as intratumoral budding as it is not possible to consider a biopsy as representative of the entire tumor invasion front 18 . Few studies 24,78–80 assessed TB in preoperative biopsies, and in all the cases the TB resulted a reliable marker for tumor aggressiveness, suggesting that TB seemed to maintain in biopsies the same clinical relevance observed in surgical specimens. In any case, the real impact of intratumoral budding in preoperative biopsies deserves further investigations.…”

Section: Discussionmentioning

confidence: 99%

Tumor budding to investigate local invasion, metastasis, and prognosis of head and neck carcinoma: A systematic review

Zanoletti,

Daloiso,

Nicolè

et al. 2023

Head & Neck

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The aim of this systematic review is to shed light on the role of tumor budding (TB) in the biology, behavior, and prognosis of head and neck squamous cell carcinoma (HNSCC). A search was run in PubMed, Scopus, and Embase databases following PRISMA guidelines. After full‐text screening and application of inclusion/exclusion criteria, 36 articles were included. Several investigations support the prognostic role of TB, which might play a role in selecting rational treatment strategies. To achieve this goal, further research is needed for greater standardization in TB quantification. Although TB is not included as a negative prognostic factor in the current management guidelines, it might be reasonable to consider a closer follow‐up for HNSCC cases with high histopathological evidence of TB.

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Section: Discussionmentioning

confidence: 99%