Tumor necrosis factor during pregnancy and at the onset of labor and spontaneous abortion

Daher, Sílvia; Fonseca, Flavia; Ribeiro, Orlando; Musatti, Chloé C.; Gerbase‐DeLima, Maria

doi:10.1016/s0301-2115(98)00252-8

Cited by 61 publications

(38 citation statements)

References 18 publications

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“…In present study similar to recent reports, we could not found correlation between maternal resistin and insulin resistance (Megia et al, 2008;Kulik-Rechberger and Mora-Janiszewska, 2009;Kuzmicki et al, 2009). Our results are in agreement with several previous observations that found an increase in TNF-α level in pregnant as compared non pregnant subjects (Melczer, 2002;Xue-Lian et al, 2008;Daher et al, 1999) but in contradiction with these studies, we found negative correlation between gestational age and TNF-α level. Explanation account for this finding may be related to lifestyle of our subjects.…”

Section: Discussionsupporting

confidence: 89%

Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Zareian¹,

Jahromi²,

Rad³

et al. 2010

American Journal of Biochemistry and Biotechnology

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Problem statement:The purpose of this study was to evaluate the role of resistin and Tumor Necrosis Factor-α (TNF-α) in insulin resistance during pregnancy. Approach: Serum resistin and TNF-α concentrations were measured by ELISA in 86 healthy pregnant women (26, 23 and 37 of them in the 1st, 2nd and 3rd trimesters, respectively) and in 21 healthy non pregnant women in a cross sectional study. Results: Resistin concentration was significantly higher in the third trimester (9.5±3.3 ng mL −1 ) as compared with non pregnant women (7±3.3 ng mL −1 ). Serum TNF-α level were also significantly increase in pregnant women (2.6±1.9 pg mL −1 ) as compared with maternal healthy controls (0.8 ±0.7 pg mL −1 ). There were significant correlation between gestational age and BMI (r = 0.28, p = 0.01), resistin (r = 0.36, p = 0.002) and TNF-α (r = -0.44, p<0.0001). There was not significant correlation between gestational age and Insulin Resistance (IR). We also did not found correlation between IR and resistin as well as between IR and TNF-α in pregnant women. Conclusion: TNF-α and resistin do not appear to contribute greatly to pregnancy induced insulin resistance in healthy pregnancy.

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Section: Discussionsupporting

confidence: 89%

Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Zareian¹,

Jahromi²,

Rad³

et al. 2010

American Journal of Biochemistry and Biotechnology

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“…72 In normal pregnancy, TNF-␣ is low in the first trimester and subsequently increases with advancing gestational age. 73 Some 74,75 but not all 76 studies report higher plasma TNF-␣ levels in women with established preeclampsia. In addition, increased levels of TNF-␣ antigen and mRNA have been described in placental tissue from preeclamptic women.…”

Section: Tumor Necrosis Factormentioning

confidence: 99%

Brief Review: Hypertension in Pregnancy

2001

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Abstract-Pregnancy-induced hypertension (PIH), which includes both gestational hypertension and preeclampsia, is a common and morbid pregnancy complication for which the pathogenesis remains unclear. Emerging evidence suggests that insulin resistance, which has been linked to essential hypertension, may play a role in PIH. Conditions associated with increased insulin resistance, including gestational diabetes, polycystic ovary syndrome, and obesity, may predispose to hypertensive pregnancy. Furthermore, metabolic abnormalities linked to the insulin resistance syndrome are also observed in women with PIH to a greater degree than in normotensive pregnant women: These include glucose intolerance, hyperinsulinemia, hyperlipidemia, and high levels of plasminogen activator inhibitor-1, leptin, and tumor necrosis factor-␣. These observations suggest the possibility that insulin resistance may be involved in the pathogenesis of PIH and that approaches that improve insulin sensitivity might have benefit in the prevention or treatment of this syndrome, although this requires further study. (Hypertension. 2001;37:232-239.)

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“…Another important issue concerns the characterization of the immunological profile of the maternal-fetal relationship. Several studies showed that the pattern of cytokines is variable throughout pregnancy, and the observed effects depend on the concentration and the period (Daher et al 1999). In this paper a non-well-defined pattern of response between cytokine relationships of Th1 and Th2 profiles in bitches is noticeable.…”

Section: Wegmannmentioning

confidence: 69%

Profile of IL-2, IL-4, IL-10, IFN- ? , TNF- ? and KC-like cytokines in pregnant bitches

Feliciano

Silva

Crivelaro

et al. 2014

Arq. Bras. Med. Vet. Zootec.

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The aim of this study was to determine the profile of IL-2, IL-4, IL-10, IFN-γ, and TNF-α cytokines and KC-like cells (natural killer) in pregnant bitches, unpublished values for the species. A total of 27 females of the Shi Tzu, Pug, English Bulldog and French breeds, weighing 4-20kg and aged 4-6 years were used. Blood samples were collected from bitches during the anestrous and on the 2nd, 5th, 6th, 7th and 8th week of pregnancy. Serum levels of cytokines were measured by panel MILLIPLEX MAP (CCYTO-90K, MILLIPORE, Billerica, Massachusetts, USA) validated for dogs. Twenty four females showed physiological pregnancy and three bitches showed pathological pregnancy. There was no difference between cytokine values during anestrous and gestational weeks of bitches (P>0.05). However, it was possible to verify the physiological behavior of serum levels during modulation of immune response in the gestational process of animals. In animals with gestational disorders, abnormal values for IL-2, IL-4 and INF-y were noted. It was concluded that serum levels of cytokines evaluated in pregnant bitches can help the better understanding of physiological and pathological gestational processes and correlated immunology in this species.Keywords: dog, immunity, pregnancy RESUMO Objetivou-se por meio deste estudo determinar o perfil das citocinas IL-2, IL-4, IL-10, IFN-γ, TNF-α e células KC-like

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Tumor necrosis factor during pregnancy and at the onset of labor and spontaneous abortion

Cited by 61 publications

References 18 publications

Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Do Resistin and Tumor Necrosis Factor-Î± Relate to Changes in Insulin Resistance in Normal Pregnancy?

Brief Review: Hypertension in Pregnancy

Profile of IL-2, IL-4, IL-10, IFN- ? , TNF- ? and KC-like cytokines in pregnant bitches

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