Tumor necrosis factor &amp;alpha; modulates sodium-activated potassium channel SLICK in rat dorsal horn neurons via p38 MAPK activation pathway

Wang, Kun; Wang, Feng; Bao, Jun-Ping; Xie, Zhi‐Yang; Chen, Lu; Zhou, Baoyi; Xie, Xing-Hui; Wu, Xiao‐Tao

doi:10.2147/jpr.s132185

Cited by 11 publications

(3 citation statements)

References 25 publications

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“…It is known that at the early stage after peritoneal injury, inflammatory responses occur at traumatized sites, in which various proinflammatory factors (e.g., TGF-b1, TNF-a, IL-1b, and IL-6) are released (Zhang et al, 2014). The MAPK inflammation signaling pathway has been reported to be activated by these proinflammatory cascades (Wang et al, 2017). As TGF-b1 and TNF-a were effectively suppressed by CCS (Figs.…”

Section: Discussionmentioning

confidence: 98%

“…10). It has been reported that the activation of the MAPK pathway can also be regulated by IL-1b and IL-6, causing inflammation within injured tissues (Wang et al, 2017). In addition to the MAPK pathway, inflammatory pathways such as Nuclear Factor-k-gene Binding(NF-kB) (Tsai et al, 2013), MEK/ERK (Samarakoon et al, 2005), and Ras homologue protein/Rho associated coiled coil forming protein (Rao et al, 2017) are associated with the formation of intra-abdominal adhesion (Supplemental Fig.…”

Section: Discussionmentioning

confidence: 99%

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A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats

Tian

et al. 2017

J Pharmacol Exp Ther

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Intra-abdominal adhesion is a common complication after laparotomy. Conventional therapeutic strategies still cannot safely and effectively prevent this disorder. In this study, a combination of chitosan, cellulose, and seaweed polysaccharide (thereafter referred as CCS) was developed to significantly alleviate the formation of postoperative adhesion in rats with abdominal trauma. Transforming growth factor 1 (TGF-1, an important promoter of fibrosis) and its downstream factors-namely, alpha-smooth muscle actin and plasminogen activator inhibitor-1 (PAI-1)-were effectively suppressed by CCS in vivo, and as a result, the activation of tissue plasminogen activator (tPA, may generate plasmin that is a fibrinolytic factor capable of breaking down fibrin) was significantly promoted, presenting antifibrosis effects of CCS. In addition, the activity of kinases [e.g., transforming growth factor-activated kinase 1 (TAK1), c-Jun N-terminal kinase (JNK)/Stress-activated Protein Kinase (SAPK), and p38] in the mitogen-activated protein kinase (MAPK) inflammation signaling pathway was also significantly suppressed by CCS in vivo, demonstrating anti-inflammatory functions of CCS. The histologic studies further confirmed the role of CCS in the inhibition of fibrosis, collagen deposition, inflammation, and vascular proliferation. These results indicate the clinical potential of CCS in the treatment of postoperative intra-abdominal adhesion. CCS may induce both antifibrosis and anti-inflammatory effects, potentially inhibiting the postoperative intra-abdominal adhesion. For antifibrosis effects, the expression of PAI-1 (a key factor for the adhesion formation) can be regulated by different TGF-1-associated signaling pathways, such as the Smads/p53 pathway, metalloproteinase/tissue inhibitor of matrix metalloproteinases pathway, Mitogen-activated Extracellular signal-regulated Kinase (MEK)/extracellular regulated protein kinase (ERK) pathway, and Yes-associated protein/transcriptional coactivator with PDZ-binding motif pathway. Following the downregulation of PAI-1 achieved by CCS, the activation of tPA (which may generate plasmin that is a fibrinolytic factor capable of breaking down fibrin) is significantly promoted. For anti-inflammation effects, CCS may suppress the phosphorylation of classic kinases (e.g., TAK1, JNK, and p38) in the MAPK signaling pathway. In addition to the MAPK pathway, inflammatory pathways, such as Nuclear Factor-κ-gene Binding(NF-κB), MEK/ERK, and Ras homologue protein/Rho associated coiled coil forming protein, are associated with the formation of intra-abdominal adhesion. Therefore, the prevention mechanisms of CCS will be further investigated in the future, with a hope of fully understanding of antiadhesion effects.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats

Tian

et al. 2017

J Pharmacol Exp Ther

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“…P38 MAPK, ERK1/2, and JNK pathways are different MAPKs pathway isoforms. When stimulated by different growth factors, cytokines, or pathogens, the MAPKs signaling pathways are activated to participate in the regulation of immune response or inflammatory response by influencing the pathway downstream of multiple cytokines [29][30][31][32]. The MAPK/ERK pathway can also be activated by stressful stimuli and plays an important role in pain development [33].…”

Section: Kyoto Encyclopedia Of Genes and Genomes And Gene Ontology Pa...mentioning

confidence: 99%

Quality evaluation of the classical prescription, Danggui Jianzhong decoction, using ultra‐high‐performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology

Feng

Wang

et al. 2022

J of Separation Science

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Danggui Jianzhong decoction is a classical prescription that has been widely used for thousands of years. However, the quality of this formula is difficult to control owing to its complex chemical component system. In this study, a simple and efficient method comprising ultra-high-performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology was established to evaluate the quality of this decoction. A total of 20 common peaks were obtained by fingerprint analysis and 19 chemicals were identified. The fingerprint similarity of 15 batch samples ranged from 0.963 to 0.991. Chemical pattern recognition analysis could clearly classify 15 batches of Danggui Jianzhong decoction into three groups. Further, seven chemical markers were screened out. A herbs-active components-targets-disease network was constructed and enrichment analyses were performed, which indicated that these 19 chemical components are the medicinal substances of Danggui Jianzhong decoction. Further, the mechanism employed by this formula to treat primary dysmenorrhea may be related to the regulation of inflammatory response. In conclusion, this combination approach enables accurate evaluation and prediction of the quality of Danggui Jianzhong decoction, and lays the foundation for studies on the material basis and exploration of the mechanism of Danggui Jianzhong decoction in the treatment of primary dysmenorrhea.

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Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury

Liu,

Sun,

Shi

et al. 2023

Neurochem Res

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Tumor necrosis factor α modulates sodium-activated potassium channel SLICK in rat dorsal horn neurons via p38 MAPK activation pathway

Cited by 11 publications

References 25 publications

A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats

A Combination of Chitosan, Cellulose, and Seaweed Polysaccharide Inhibits Postoperative Intra-abdominal Adhesion in Rats

Quality evaluation of the classical prescription, Danggui Jianzhong decoction, using ultra‐high‐performance liquid chromatography fingerprint, chemical pattern recognition, and network pharmacology

Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Injury

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