Tumor Necrosis Factor Alpha Influences the Inflammatory Response After Coronary Surgery

Bittar, Mohamad; Carey, John A.; Barnard, James; Pravica, Vera; Deiraniya, Abdul K.; Yonan, N.; Hutchinson, Ian V.

doi:10.1016/j.athoracsur.2005.07.037

Cited by 40 publications

(30 citation statements)

References 21 publications

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“…22,[25][26][27][28] As a pro-inflammatory cytokine, TNF plays a key role in the inflammatory response after CPB. 29 TNF-a level peaks shortly after surgery and is rapidly degraded afterwards. Excessive production of TNF-a may lead to organ dysfunction or death.…”

Section: Introductionmentioning

confidence: 99%

“…30,31 There is increasing evidence that inter-individual differences in TNF-a productions are caused by genetic variability. 8,14,27,29,[32][33][34] Nevertheless, the clinical impact of those genetic variants needs validation in large cohorts. This study investigates in a large, prospectively enrolled patient cohort whether the individual variability in the ApoE (E2,E3,E4) genotype or TNFa-308 G4A has an influence on the development of postoperative CSA-AKI.…”

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

et al. 2013

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Objectives: Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short-and long-term outcome. We analyzed two common genetic polymorphisms that have previously been linked to renal failure and inflammation, and have been supposed to be associated with cardiac surgery associated-acute kidney injury (CSA-AKI). Methods: A total of 1415 consecutive patients who underwent elective cardiac surgery with CPB at our institution were prospectively enrolled. Patients were genotyped for Apolipoprotein E (ApoE E2,E3,E4) (rs429358 and rs7412) and TNF-a-308 G4A (rs1800629). Results: Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between ApoE (E2,E3,E4) and TNF-a-308 G4A genotypes and the RIFLE criteria could be detected. Several multiple linear regression analyses for postoperative creatinine increase revealed highly significant associations for aortic cross clamp time (p50.001), CPB-time (p50.001), norepinephrine (p50.001), left ventricular function (p ¼ 0.004) and blood transfusion (p50.001). No associations were found for ApoE (E2,E3,E4) and TNF-a-308 G4A genotypes or baseline creatinine. When the sample size is 1415, the multiple linear regression test of R 2 ¼ 0 for seven covariates assuming normal distribution will have at least 99% power with significance level 0.05 to detect an R 2 of 0.108 or 0.107 as observed in the data. Conclusions: ApoE (E2,E3,E4) polymorphism and the TNF-a-308 G4A polymorphism are not associated with renal injury after CPB.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

et al. 2013

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“…Compared to TNF-α-308 G, the TNF-α-308 A allele has been shown to increase the plasma cytokine level and to correlate with high in vitro TNF-α gene transcription and expression. [31][32][33] It also has been demonstrated that the TNF-α-308 A allele could increase the risk of acute rejection. 5,[34][35][36][37] Interestingly, HLA-matched allogeneic donorrecipient pairs often are mismatched for microsatellite markers in the class III region, leading to complications after allogeneic hematopoietic stem cell transplants.…”

Section: Discussionmentioning

confidence: 99%

Linkage Disequilibrium Between TNF-α-308 G/A Promoter and Histocompatibility Leukocyte Antigen Alleles in Han-Nationality Lung Transplant Recipients From Eastern China

Ji²,

Xie³

et al. 2013

Exp Clin Transplant

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“…M. Bittar и соавт. [5] изучали взаимосвязь между полиморфизмом -308G/A TNF-α с уровнями ци-токина в плазме и клиническим течением у пациентов по-сле операции АКШ. Показано, что пациенты, гомозигот-ные по аллелю -308А, имели более высокие уровни TNF-α после операции (р=0,009).…”

Section: Tnf-αunclassified

The importance of genetic polymorphism of inflammatory response mediators in the development of complications after cardiac surgery (literature review)

Buziashvili¹,

Koksheneva²,

Abukov³

et al. 2016

Kardiol. serdechno-sosud. khir.

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Tumor Necrosis Factor Alpha Influences the Inflammatory Response After Coronary Surgery

Cited by 40 publications

References 21 publications

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

Apolipoprotein E genotype, TNF-α 308G/A and risk for cardiac surgery associated-acute kidney injury in Caucasians

Linkage Disequilibrium Between TNF-α-308 G/A Promoter and Histocompatibility Leukocyte Antigen Alleles in Han-Nationality Lung Transplant Recipients From Eastern China

The importance of genetic polymorphism of inflammatory response mediators in the development of complications after cardiac surgery (literature review)

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