Tumor necrosis factor‐alpha gene (TNF‐α) −1031/−863, −857 single‐nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese

Abstract

Since the frequency of subjects who carried at least one variant allele in TNF-alpha-1031, -863 or -857 SNPs was higher in periodontitis patients than in healthy subjects, TNF-alpha-1031, -863 and -857 SNPs appear to be associated with severe adult periodontitis in Japanese populations.

Role of the polymorphic IL‐1B, IL‐1RN and TNF‐A genes in distal gastric cancer in Mexico

“…An example of this is the role of the TNF-A-1031, -863 and -857 variants, which are observed in a relatively large proportion in Japanese populations and have a more marked influence on risk of several inflammatory conditions. 26 In summary, our study has confirmed that the proinflammatory IL-1B-31 genotypes contribute significantly to the risk of GC in a Hispanic population, mirroring the findings in Caucasians and Asians. This underscores the very important role that this cytokine plays in the pathogenesis of H. pylori-related gastric cancer.…”

Study the Impact of T-helper 1 Cytokine (TNF-α) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah Region

“…One of them is transition replacement of adenine for guanine at positions -308 and the second polymorphism is transition replacement of thymine for cytosine at position -857. All PCR reactions were run under conditions previously described (Fargion et al, 2001;Soga et al, 2003). Primer sequences for the polymorphism at position -857(rs1799724) are sense 5′-AAG TCG AGT ATG GGG ACC CCC CGT TAA-3′ and anti-sense 5′-CCC CAG TGT GTG GCC ATA TCT TCT T-3′, those for the gene polymorphism at position -308 (rs361525) are forward 5′-GGG ACA CAC AAG CAT CAA GG-3′ and reverse 5′-GGG ACA CAC AAG CAT CAA GG-3′.…”

Association of tumor necrosis factor‐α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

“…[8][9][10] Several functional promoter polymorphisms have been identified in this gene. [11][12][13][14][15] There is emerging evidence that of an association of TNF-α-308 polymorphism, a G/A transition at -308-bp position, which may alter promoter activity, with TNF-α expression in vitro, as well as plasma concentrations. 16 An increased serum concentration of TNF-α is an independent predictor of cardiovascular disease 17 and is a marker for recurrent coronary events following a previous acute myocardial infarction.…”