Tumor necrosis factor‐alpha expression and detection of apoptosis at the site of chronic periodontitis in AIDS patients

Vieira, Beatriz Julião; Souza, Andrezza Rodrigues De; Aarestrup, Fernando Monteiro

doi:10.1034/j.1600-0765.2003.00701.x

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The prevalence of pro‐inflammatory cytokines in crevicular fluid is in agreement with the significant increased synthesis of the same cytokines by monocytes from HIV + patients compared with that in healthy individuals following challenge of these cells with periodontopathogens and LPS (Baqui et al , 2000a). In addition, an altered apoptosis of mononuclear cells in gingival tissue from HIV + patients correlates well with the Th1 gingival response in periodontal disease of these patients, because their prolonged presence at the periodontitis sites would guarantee a constant production of inflammatory Th1 cytokines that promotes more aggressive tissue destructions (Vieira et al , 2003).…”

Section: Hypothesis: Oral Co‐infections As a Risk Factor For Hiv Recrmentioning

confidence: 99%

Oral infectious diseases: a potential risk factor for HIV virus recrudescence?

2009

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As the highly active antiretroviral therapy (HAART) has transitioned human immunodeficiency virus (HIV) infection into a ‘chronic disease’ management strategy, there is growing evidence that infection with non-HIV pathogens in HIV+ patients may have important public health implications in undermining HAART success and acquired immunodeficiency syndrome progression. Several bacterial and host cell products during infections with non-HIV pathogens have shown the capacity to regulate HIV replication in latently infected cells. A high prevalence of oral infections caused by bacteria, viruses and fungi has been described in HIV+ patients, including periodontal disease. The oral cavity appears to be a site of HIV pathogenesis and potential reservoir for the disease as HIV RNA and DNA forms are present in saliva as well as in gingival crevicular fluid, and oral epithelial cells are susceptible to either cell free or cell-associated HIV infection. The clinical and biological bases of potential associations between chronic oral inflammatory disorders, such as periodontal disease, and exacerbation of HIV viraemia have received little attention. This review attempts to evaluate the current understanding of HIV reactivation as a result of co-infection and/or inflammation induced by non-HIV pathogens in HIV-infected patients, and presents a hypothetic model about the potential role of periodontitis as a global oral infection that potentially contributes to HIV recrudescence.

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Section: Hypothesis: Oral Co‐infections As a Risk Factor For Hiv Recrmentioning

confidence: 99%

Oral infectious diseases: a potential risk factor for HIV virus recrudescence?

2009

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Role of macrophages in LPS-induced osteoblast and PDL cell apoptosis

Thammasitboon

Goldring

Boch

2006

Bone

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Imunohistoquímica Para Receptor De Prolactina E Apoptose Em Glândulas Mamárias De Camundongos Mus Muscullus (Linnaeus) Durante a Lactação

Souza,

Peters,

Farias

et al. 2004

Arq. Inst. Biol.

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RESUMO A lactação é indispensável para o crescimento e o desenvolvimento de recém-nascidos. Drogas administradas no período de lactação podem alterar o desenvolvimento da cria, ou lesar a glândula mamária alterando a produção de leite. Poucos estudos foram encontrados sobre a evolução da expressão de receptores de prolactina e de presença de células apoptóticas em ácinos da glândula mamária de fêmeas de camundongos, durante o processo de lactação, sendo este o objetivo do presente trabalho. Glândulas mamárias de fêmeas de camundongos foram obtidas no 19o dia de prenhez e em diferentes dias da lactação. Foram avaliados: o número de alvéolos por campo e o número de células por alvéolo. Identificou-se a expressão de receptores para prolactina através de imunohistoquímica, e a presença de células apoptóticas pelo método tunel. A presença de células prolactinas positivas, discreta no final da prenhez, aumenta significativamente já no 1o dia de lactação e permanece assim até o desmame. A involução da glândula mamária, indicada pelo aumento do número de células em processo de apoptose se inicia por volta do 8o dia pós-natal e prossegue até ao desmame.

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Tumor necrosis factor‐alpha expression and detection of apoptosis at the site of chronic periodontitis in AIDS patients

Abstract: These data suggested an important role of the apoptosis of mononuclear cells in the pathogenesis of chronic adult periodontitis in AIDS patients.

Cited by 4 publications

References 41 publications

Oral infectious diseases: a potential risk factor for HIV virus recrudescence?

Oral infectious diseases: a potential risk factor for HIV virus recrudescence?

Role of macrophages in LPS-induced osteoblast and PDL cell apoptosis

Imunohistoquímica Para Receptor De Prolactina E Apoptose Em Glândulas Mamárias De Camundongos Mus Muscullus (Linnaeus) Durante a Lactação

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