Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo

Singh, Mala; Mansuri, Mohmmad Shoab; Kadam, Ashlesha; Palit, Sayantani Pramanik; Dwivedi, Mitesh; Laddha, Naresh C.; Begum, Rasheedunnisa

doi:10.1016/j.cyto.2021.155432

Cited by 29 publications

(30 citation statements)

References 58 publications

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“…Fibroblasts cultivated with conditioned medium obtained from immortalized human keratinocytes (HaCaT) treated with PM displayed increased nuclear translocation of p65 and p50 as well as increased ROS production, morphological changes, and secretion of SASP components including prostaglandin E2, COX-2, TNF-α, IL-1β, and IL-6 [ 93 ]. It is well established that the expression and release of TNF-α is increased upon UV exposure [ 105 ] as well in some skin diseases such as vitiligo [ 106 ].…”

Section: Major Components Of Air Pollution Affecting Skin Appearancementioning

confidence: 99%

Effects of Air Pollution on Cellular Senescence and Skin Aging

Martic

Jansen-Duerr

Cavinato

2022

Cells

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The human skin is exposed daily to different environmental factors such as air pollutants and ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin and is known to promote aging and inflammation of this tissue, leading to the onset of skin disorders and to the appearance of wrinkles and pigmentation issues. Besides this, components of air pollution can interact synergistically with ultraviolet light and increase the impact of damage to the skin. However, little is known about the modulation of air pollution on cellular senescence in skin cells and how this can contribute to skin aging. In this review, we are summarizing the current state of knowledge about air pollution components, their involvement in the processes of cellular senescence and skin aging, as well as the current therapeutic and cosmetic interventions proposed to prevent or mitigate the effects of air pollution in the skin.

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Section: Major Components Of Air Pollution Affecting Skin Appearancementioning

confidence: 99%

Effects of Air Pollution on Cellular Senescence and Skin Aging

Martic

Jansen-Duerr

Cavinato

2022

Cells

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“…IFNγ and TNFα have similar effects on melanocytes with increased apoptosis, inhibition of differentiation, and upregulation of several factors involved in the recruitment and activation of immune cells and antigen presentation (Nordlund, 2007b;Tulic et al, 2019;Webb et al, 2015; Table 1). An interesting phenomenon induced by decreased activity of antigen-specific T cells (Boukhedouni et al, 2020;Richmond et al, 2013;Singh et al, 2021;Taube et al, 2012;Tulic et al, 2019;S. Wang, Zhou, et al, 2014;Webb et al IFNγ, type I cytokines and TNFα is the reduction of melanocyte attachment via E-cadherin to surrounding epidermal cells (Table 1).…”

Section: The Influence Of Cytokines and Chemokines On Melanocytesmentioning

confidence: 99%

“…Other factors inducing melanocyte proliferation are leukotrienes, peptides, and growth factors (Table 1). In contrast, IL‐1, IL‐6, TNF‐α, TNF‐β, TGF‐β1, and IFN‐γ inhibit the proliferation of pigment cells (Krasagakis et al, 1995; Richmond et al, 2013; Singh et al, 2021). A broad range of cytokines has been associated with decreased tyrosinase activity and melanin formation (Table 1).…”

Section: Melanocytes and Immunitymentioning

confidence: 99%

The delicate relation between melanocytes and skin immunity: A game of hide and seek

Speeckaert

Belpaire

Speeckaert

et al. 2022

Pigment Cell Melanoma Res

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Melanocytes exhibit a complex and intriguing relationship with the skin immune response, leading to several clinical conditions. In some disorders, inappropriate melanocyte destruction (e.g., vitiligo, halo naevi) is problematic, while in others, immune tolerance should be broken (melanoma). Important parts of the dysregulated pathways have been unraveled in pigment disorders, ranging from upregulated interferon (IFN)‐γ signaling to memory T cells, regulatory T cells, and immune checkpoints. Although a network of many factors is involved, targeting key players such as IFN‐γ or checkpoint inhibitors (e.g., programmed death‐ligand 1 (PD‐L1)] can shift the balance and lead to impressive outcomes. In this review, we focus on the immunological mechanisms of the most common inflammatory disorders where the interaction of the immune system with melanocytes plays a crucial role. This can provide new insights into the current state of melanocyte research.

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“…TNFα activity is increased in active vitiligo lesions [ 43 ]. TNFα induces melanocyte dysfunction and cellular death through several mechanisms [ 43 , 44 ]: it produces its effects acting upon the microphthalmia-associated transcription factor (MITF), melanocyte-stimulating hormone receptor (MSH-R) activity and reducing the expression of melanocortin-1 receptor (MC1-R), thus inducing melanocyte toxicity and enhancing ROS production [ 43 , 44 ]. Nevertheless, this pro-inflammatory cytokine appears to also play a protective role in vitiligo, activating and promoting the development of T reg cells [ 45 ].…”

Section: Vitiligo Pathogenesis: Ab Origine Development From Gene To Cellular Dynamicsmentioning

confidence: 99%

Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments

Custurone

Bartolomeo

Irrera

et al. 2021

IJMS

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Vitiligo is a chronic autoimmune dermatosis of which the pathogenesis remains scarcely known. A wide variety of clinical studies have been proposed to investigate the immune mediators which have shown the most recurrency. However, such trials have produced controversial results. The aim of this review is to summarize the main factors involved in the pathogenesis of vitiligo, the latest findings regarding the cytokines involved and to evaluate the treatments based on the use of biological drugs in order to stop disease progression and achieve repigmentation. According to the results, the most recurrent studies dealt with inhibitors of IFN-gamma and TNF-alpha. It is possible that, given the great deal of cytokines involved in the lesion formation process of vitiligo, other biologics could be developed in the future to be used as adjuvants and/or to entirely replace the treatments that have proven to be unsatisfactory so far.

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Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo

Cited by 29 publications

References 58 publications

Effects of Air Pollution on Cellular Senescence and Skin Aging

Effects of Air Pollution on Cellular Senescence and Skin Aging

The delicate relation between melanocytes and skin immunity: A game of hide and seek

Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments

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