Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

Yang, Zhaohui; Costanzo, Mario; Golde, DW; Kolesnick, Richard

doi:10.1016/s0021-9258(20)80756-x

Cited by 163 publications

(14 citation statements)

References 25 publications

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“…The concept of costimulation allows interpretation of the role of ceramide as mediator of Fas-and TNF-induced apoptosis to be viewed in the context of reciprocal regulation of cell death versus proliferation by lipid second messengers. Cellular stimulation with bacterial sphingomyelinase, ceramide analogues, or TNF induces apoptosis in sensitive cell lines concomitant with relatively large elevations in cellular ceramide content and without effect on cellular DG levels (16,29,31). This contrasts with the costimulation phenomenon through IL-1 or CD28 and the TCR, in which elevation of cellular ceramide content likely occurs together with DG, and proliferation and T cell activation ensue.…”

Section: Coordinate Signaling Through Ceramide and Dgmentioning

confidence: 97%

Ceramide: a signal for apoptosis or mitogenesis?

Kolesnick

Fuks

1995

The Journal of Experimental Medicine

152

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Section: Coordinate Signaling Through Ceramide and Dgmentioning

confidence: 97%

Ceramide: a signal for apoptosis or mitogenesis?

Kolesnick

Fuks

1995

The Journal of Experimental Medicine

152

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“…Par-4 binding to PKC in transfection experiments may be due to the fact that overexpression by ceramide appears to be of functional relevance. Thus, ceramide is a potent activator of NF-B (Schu ¨tze et al, of the protein lowers the requirement of the second signal necessary for this binding to occur in a more 1992; Yang et al, 1993), and it has been shown that expression of a dominant-negative mutant of the atypi-physiological environment. Ceramide also activates this association in HeLa cells (data not shown), suggesting cal PKCs severely impairs B-dependent promoter activation by sphingomyelinase (Lozano et al, 1994).…”

mentioning

confidence: 99%

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

Diaz‐Meco

Municio

Frutos

et al. 1996

Cell

358

377

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The atypical PKCs are involved in a number of important cellular functions, including cell proliferation. We report here that the product of the par-4 gene specifically interacts with the regulatory domains of zeta PKC and lambda/LPKC, which dramatically inhibits their enzymatic activity. This is particularly challenging, because expression of par-4 has been shown to correlate with growth inhibition and apoptosis. Results are shown here demonstrating that the expression of par-4 in NIH-3T3 cells induces morphological changes typical of apoptosis, which are abrogated by cotransfection of either wild-type zeta PKC or lambda/LPKC, but not by their respective kinase-inactive mutants. These findings support a role for the atypical PKC subspecies in the control of cell growth and survival.

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“…No measurable accumulation of virus was observed after 24 hours of culture; however, the ce~~s,7.15,16,i8,20,22,2S.26. 28 Our initial experiments were designed levels reached after 2 days of incubation were quantitatively equivalent to those observed in cultures stimulated for 12 hours with TNF or sphingomyelinase (compare Fig 3B with Fig 1A). Maximal accumulation of virus in the culture supernatants was observed after 3 days of culture.…”

Section: 5mentioning

confidence: 66%

Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells

Rivas

Golde

Vera

et al. 1994

Blood

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Tumor necrosis factor (TNF) is a potent inducer of human immunodeficiency virus (HIV) proviral transcription and subsequent mature virus production. Recent investigations have shown that TNF can use a signal transduction pathway in HL-60 cells involving sphingomyelin hydrolysis to ceramide with subsequent stimulation of a ceramide-linked kinase. When sphingomyelinase was added exogenously to activate this cascade in HIV-1-infected HL-60 cells, it mimicked TNF- induced HIV production. Phospholipases A2, C, or D, which do not generate ceramide, had no effect; however, a synthetic ceramide analog added exogenously potently induced HIV production. In addition, anti- TNF antibodies blocked much of the effect of both sphingomyelinase and the synthetic ceramide analog on virus expression, suggesting that, although signaling is initiated through the sphingomyelin pathway, it is sustained by autocrine TNF synthesis. Thus, direct activation of the sphingomyelin pathway recapitulated the effect of TNF on both HIV and TNF production. These studies indicate that the sphingomyelin pathway is involved in TNF signaling for HIV production in chronically infected myeloid cells.

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Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.

Cited by 163 publications

References 25 publications

Ceramide: a signal for apoptosis or mitogenesis?

Ceramide: a signal for apoptosis or mitogenesis?

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells

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