Tumor-microenvironment-responsive poly-prodrug encapsulated semiconducting polymer nanosystem for phototherapy-boosted chemotherapy

Abstract

Phototherapy induced hypoxia in the tumor microenvironment (TME) is responsible for the diminished therapeutic efficacy. Designing an intelligent nanosystem capable of responding to hypoxia for TME responsive drug delivery will,...

Synthesis of a new photosensitizer for ablation of Uppsala 87 Malignant Glioma cells

“…BTR was synthesized by the condensation reaction and characterized by 1 HNMR, 13 CNMR, and maldi-tof (Figure S1-S3), whose results confirmed the purity of it. In cancer nanomedicine, nanoformulation significantly improves colloidal stability and stealth effects.…”

“…[2][3][4][5] A photosensitizer (PS) plays a vital role in PDT because it can generate reactive oxygen species (ROS) with light irradiation, which can induce cell apoptosis by oxidizing mitochondria and nuclei. [5][6] So far, a variety of PSs, such as porphyrin, [7][8][9][10][11] 1,4-diketopyrrolo-[3,4-c]-pyrroles (DPP), [12][13][14][15][16][17][18][19][20][21] boron dipyrromethene (BODIPY), [21][22][23][24][25][26][27][28][29][30][31] have been developed as potential candidates for dual use as both therapeutic and imaging agent. These compounds, however, still suffer from some disadvantages, such as low reactive oxygen species generation ability and poor water solubility.…”

Theranostics - a sure cure for cancer after 100 years?

“…Continuous irradiation during PDT can deteriorate tumor hypoxia because it not only consumes intracellular oxygen but also damages tumor blood vessels, limiting the phototherapeutic effect 90 . To improve PDT performance, there are generally two ways to relieve tumor hypoxia: one is the delivery of the molecular oxygen to the tumor using carriers, such as perfluorocarbon 87 , 97 , 102 , and the other one is fractionated PDT 98 , 101 , 103 .…”

Synthesis of a new photosensitizer for photodynamic and photothermal synergistic cancer therapy

“…Materials Advances is similar to that of the control group, indicating the low dark toxicity of TDPP NPs themselves. [36][37][38][39] In comparison, obvious tumor suppression was observed for those treated with PDIDPP NPs with the help of light. Tumors in the PDIDPP NPs + light group disappeared thoroughly.…”