Tumor microenvironment-responsive histidine modified-hyaluronic acid-based MnO2 as in vivo MRI contrast agent

Hong, Ji Yeon; Lim, Yong Geun; Song, Young-Hwan; Park, Kyeongsoon

doi:10.1016/j.ijbiomac.2022.12.033

Cited by 11 publications

(4 citation statements)

References 49 publications

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“…This promising label-free non-invasive imaging technique can be used to monitor dynamic changes in composition, with the exchangeable hydroxyl protons (i.e., single bond OH) [77,78]. Alternatively, HA hydrogel fluorination and other labeling methods to enhance contrast in MRI are available [79][80][81]. Therefore, potential options for further in vivo characterization of the effects of the combination products studied herein could comprise CEST MRI or appropriate hydrogel labeling for the rationalization of animal experimentation and potential enhancement of result quality and quantity, compared to standard in vivo preclinical trials.…”

Section: Study Limitations and Perspectives For Future Workmentioning

confidence: 99%

Lyophilized Progenitor Tenocyte Extracts: Sterilizable Cytotherapeutic Derivatives with Antioxidant Properties and Hyaluronan Hydrogel Functionalization Effects

Laurent

Porcello

Jeannerat³

et al. 2023

Antioxidants

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Cultured primary progenitor tenocytes in lyophilized form were previously shown to possess intrinsic antioxidant properties and hyaluronan-based hydrogel viscosity-modulating effects in vitro. The aim of this study was to prepare and functionally characterize several stabilized (lyophilized) cell-free progenitor tenocyte extracts for inclusion in cytotherapy-inspired complex injectable preparations. Fractionation and sterilization methods were included in specific biotechnological manufacturing workflows of such extracts. Comparative and functional-oriented characterizations of the various extracts were performed using several orthogonal descriptive, colorimetric, rheological, mechanical, and proteomic readouts. Specifically, an optimal sugar-based (saccharose/dextran) excipient formula was retained to produce sterilizable cytotherapeutic derivatives with appropriate functions. It was shown that extracts containing soluble cell-derived fractions possessed conserved and significant antioxidant properties (TEAC) compared to the freshly harvested cellular starting materials. Progenitor tenocyte extracts submitted to sub-micron filtration (0.22 µm) and 60Co gamma irradiation terminal sterilization (5–50 kGy) were shown to retain significant antioxidant properties and hyaluronan-based hydrogel viscosity modulating effects. Hydrogel combination products displayed important efficacy-related characteristics (friction modulation, tendon bioadhesivity) with significant (p < 0.05) protective effects of the cellular extracts in oxidative environments. Overall, the present study sets forth robust control methodologies (antioxidant assays, H2O2-challenged rheological setups) for stabilized cell-free progenitor tenocyte extracts. Importantly, it was shown that highly sensitive phases of cytotherapeutic derivative manufacturing process development (purification, terminal sterilization) allowed for the conservation of critical biological extract attributes.

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Section: Study Limitations and Perspectives For Future Workmentioning

confidence: 99%

Lyophilized Progenitor Tenocyte Extracts: Sterilizable Cytotherapeutic Derivatives with Antioxidant Properties and Hyaluronan Hydrogel Functionalization Effects

Laurent

Porcello

Jeannerat³

et al. 2023

Antioxidants

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“…In light of this, many Mn-based contrast agents have been developed and are particularly effective at enhancing the contrast of T 1 -weighted images. 76–78…”

Section: Mno2 For Magnetic Resonance Imagingmentioning

confidence: 99%

“…In light of this, many Mn-based contrast agents have been developed and are particularly effective at enhancing the contrast of T 1 -weighted images. [76][77][78] 3.1.2 The mechanism of MnO 2 as a T 2 contrast agent. T 2 relaxation, also known as spin-spin relaxation, refers to the decay of transverse magnetization of tissue after it has been excited by an external radiofrequency.…”

Section: Mno 2 For Magnetic Resonance Imagingmentioning

confidence: 99%

Advances in the application of manganese dioxide and its composites for theranostics

Hao

Zhao

et al. 2023

Inorg. Chem. Front.

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“…In active targeting, MNPs are conjugated with ligands that can recognize highly expressed receptors on the membranes of cancer cells and tumor-associated cells. For instance, many ligands such as transferrin, [125][126][127][128][129][130] folate, [131][132][133] hyaluronic acid, 134,135 aptamers, 136,137 antibodies, 15,[138][139][140] and peptides [141][142][143][144] have been conjugated with MNPs for active targeted delivery into brain tumor sites. 145 MNPs present unique advantages for drug delivery into brain tumors, particularly due to their strong response to EMF.…”

Section: Targeted Delivery Based On Mnps Targeted Delivery Under Emf ...mentioning

confidence: 99%

Advances in Brain Tumor Therapy Based on the Magnetic Nanoparticles

Xu,

Zhang,

Zhang

et al. 2023

IJN

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Brain tumors, including primary gliomas and brain metastases, are one of the deadliest tumors because effective macromolecular antitumor drugs cannot easily penetrate the blood-brain barrier (BBB) and blood-brain tumor barrier (BTB). Magnetic nanoparticles (MNPs) are considered the most suitable nanocarriers for the delivery of brain tumor drugs because of their unique properties compared to other nanoparticles. Numerous preclinical and clinical studies have demonstrated the potential of these nanoparticles in magnetic targeting, nuclear magnetic resonance, magnetic thermal therapy, and ultrasonic hyperthermia. To further develop and optimize MNPs for the diagnosis and treatment of brain tumors, we attempt to outline recent advances in the use of MNPs to deliver drugs, with a particular focus on their efficacy in the delivery of anti-brain tumor drugs based on magnetic targeting and low-intensity focused ultrasound, magnetic resonance imaging for surgical real-time guidance, and magnetothermal and ultrasonic hyperthermia therapy. Furthermore, we summarize recent findings on the clinical application of MNPs and the research limitations that need to be addressed in clinical translation.

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Tumor microenvironment-responsive histidine modified-hyaluronic acid-based MnO2 as in vivo MRI contrast agent

Cited by 11 publications

References 49 publications

Lyophilized Progenitor Tenocyte Extracts: Sterilizable Cytotherapeutic Derivatives with Antioxidant Properties and Hyaluronan Hydrogel Functionalization Effects

Lyophilized Progenitor Tenocyte Extracts: Sterilizable Cytotherapeutic Derivatives with Antioxidant Properties and Hyaluronan Hydrogel Functionalization Effects

Advances in the application of manganese dioxide and its composites for theranostics

Advances in Brain Tumor Therapy Based on the Magnetic Nanoparticles

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