Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment

Wang, Yandong; Gao, Fucheng; Li, Xiaofeng; Niu, Guiming; Yang, Yufei; Li, Hui; Jiang, Yanyan

doi:10.1186/s12951-022-01278-z

Cited by 47 publications

(29 citation statements)

References 155 publications

(201 reference statements)

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“…Among the liquid metals, an important class is eutectic gallium-indium alloys, which can produce ROS under microwave radiation. (4) Fenton catalysts (e.g., iron ions, copper sulfide, Cu I , and Mn 2+ ) can mediate the Fenton reaction to achieve redox reactions and promote the generation of ROS [38][39][40]. Iron ions are the most widely studied metal ions with Fenton activity and have recently been popularly researched.…”

Section: Oxidative Modulatorsmentioning

confidence: 99%

Advances in Delivering Oxidative Modulators for Disease Therapy

Wei

Yue

et al. 2022

Research

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Oxidation modulators regarding antioxidants and reactive oxygen species (ROS) inducers have been used for the treatment of many diseases. However, a systematic review that refers to delivery system for divergent modulation of oxidative level within the biomedical scope is lacking. To provide a comprehensive summarization and analysis, we review pilot designs for delivering the oxidative modulators and the main applications for inflammatory treatment and tumor therapy. On the one hand, the antioxidants based delivery system can be employed to downregulate ROS levels at inflammatory sites to treat inflammatory diseases (e.g., skin repair, bone-related diseases, organ dysfunction, and neurodegenerative diseases). On the other hand, the ROS inducers based delivery system can be employed to upregulate ROS levels at the tumor site to kill tumor cells (e.g., disrupt the endogenous oxidative balance and induce lethal levels of ROS). Besides the current designs of delivery systems for oxidative modulators and the main application cases, prospects for future research are also provided to identify intelligent strategies and inspire new concepts for delivering oxidative modulators.

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Section: Oxidative Modulatorsmentioning

confidence: 99%

Advances in Delivering Oxidative Modulators for Disease Therapy

Wei

Yue

et al. 2022

Research

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“…So far, only a few forms of metal peroxide have been described for tumor treatment, with the majority of the studies focusing on CaO 2 -based nanostructures [154,155]. Other metal peroxide-based nanoparticles, such as MgO 2 , BaO 2 , ZnO 2 , and CuO 2 -based materials, have yet to be fully realized, and their physiological uses are equally restricted [44]. Improving them by correctly altering them or coupling them with other chemotherapeutic drugs might be a potential research trend [156].…”

Section: Targeting Metal Ion Homeostasismentioning

confidence: 99%

“…Te best way to modify size distribution and optimize NP distribution has never been straightforward [215]. Metal peroxide has been used as an oxygen-generating compound in the production of potential tumor theranostics nanoplatforms in the past few years, which may modulate the tumor microenvironment to generate a new working environment for therapies whose efectiveness is restricted by the underlying tumor microenvironment [44,46,213,215,216].…”

Section: Synthetic Procedures For Metal Peroxidesmentioning

confidence: 99%

“…Copper peroxide (CuO 2 ), calcium peroxide (CaO 2 ), magnesium peroxide (MgO 2 ), zinc peroxide (ZnO 2 ), barium peroxide (BaO 2 ), and titanium peroxide (TiOx) are some of the metal peroxide nanosystems which have attracted interest in this area. As shown in Figure 2, they have been extensively investigated in several biomedical felds, including catalytic nanomedicine, based on their reactivity for hydrogen peroxide and oxygen generation and metal ionbased bioactivity [44][45][46].…”

Section: Introductionmentioning

confidence: 99%

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Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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“…Thus, this restriction stimulates the use of alternative treatments based on raising tumor temperature that present higher penetration ability, such as microwave thermal therapy and magnetothermal therapy. This kind of therapy takes the benefits of the low temperature resistance of cancer cells compared to normal human cells and tissues and, when combined with CDT, can boost the catalytic activity of the Fenton agents [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Bioengineered Carboxymethylcellulose–Peptide Hybrid Nanozyme Cascade for Targeted Intracellular Biocatalytic–Magnetothermal Therapy of Brain Cancer Cells

et al. 2022

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Glioblastoma remains the most lethal form of brain cancer, where hybrid nanomaterials biofunctionalized with polysaccharide peptides offer disruptive strategies relying on passive/active targeting and multimodal therapy for killing cancer cells. Thus, in this research, we report for the first time the rational design and synthesis of novel hybrid colloidal nanostructures composed of gold nanoparticles stabilized by trisodium citrate (AuNP@TSC) as the oxidase-like nanozyme, coupled with cobalt-doped superparamagnetic iron oxide nanoparticles stabilized by carboxymethylcellulose ligands (Co-MION@CMC) as the peroxidase-like nanozyme. They formed inorganic–inorganic dual-nanozyme systems functionalized by a carboxymethylcellulose biopolymer organic shell, which can trigger a biocatalytic cascade reaction in the cancer tumor microenvironment for the combination of magnetothermal–chemodynamic therapy. These nanoassemblies were produced through a green aqueous process under mild conditions and chemically biofunctionalized with integrin-targeting peptide (iRDG), creating bioengineered nanocarriers. The results demonstrated that the oxidase-like nanozyme (AuNP) was produced with a crystalline face-centered cubic nanostructure, spherical morphology (diameter = 16 ± 3 nm), zeta potential (ZP) of −50 ± 5 mV, and hydrodynamic diameter (DH) of 15 ± 1 nm. The peroxide-like nanostructure (POD, Co-MION@CMC) contained an inorganic crystalline core of magnetite and had a uniform spherical shape (2R = 7 ± 1 nm) which, summed to the contribution of the CMC shell, rendered a hydrodynamic diameter of 45 ± 4 nm and a negative surface charge (ZP = −41 ± 5 mV). Upon coupling both nanozymes, water-dispersible colloidal supramolecular vesicle-like organic–inorganic nanostructures were produced (AuNP//Co-MION@CMC, ZP = −45 ± 4 mV and DH = 28 ± 3 nm). They confirmed dual-nanozyme cascade biocatalytic activity targeted by polymer–peptide conjugates (AuNP//Co-MION@CMC_iRGD, ZP = −29 ± 3 mV and DH = 60 ± 4 nm) to kill brain cancer cells (i.e., bioenergy “starvation” by glucose deprivation and oxidative stress through reactive oxygen species generation), which was boosted by the magneto-hyperthermotherapy effect when submitted to the alternating magnetic field (i.e., induced local thermal stress by “nanoheaters”). This groundwork offers a wide avenue of opportunities to develop innovative theranostic nanoplatforms with multiple integrated functionalities for fighting cancer and reducing the harsh side effects of conventional chemotherapy.

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Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment

Cited by 47 publications

References 155 publications

Advances in Delivering Oxidative Modulators for Disease Therapy

Advances in Delivering Oxidative Modulators for Disease Therapy

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Bioengineered Carboxymethylcellulose–Peptide Hybrid Nanozyme Cascade for Targeted Intracellular Biocatalytic–Magnetothermal Therapy of Brain Cancer Cells

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