Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics

Chen, Hongtao; Zhou, Bingcheng; Zheng, Xian; Wei, Jie; Ji, Chendong; Yin, Meizhen

doi:10.1039/d2bm01604d

Cited by 2 publications

(2 citation statements)

References 51 publications

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“… 16 , 17 Nanodrugs are engineered drug loaded particles on the nanometer that can specifically be delivered to cancer cells. 18 , 19 Their diminutive size allows for enhanced penetration and accumulation within tumor tissues, exploiting the abnormal vasculature associated with cancers. 20 This targeted delivery minimizes damage to healthy tissues and organs, mitigating the systemic side effects commonly observed with traditional chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Wang,

Pan,

Chen

et al. 2024

IJN

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Background The in vivo barriers and multidrug resistance (MDR) are well recognized as great challenges for the fulfillment of antitumor effects of current drugs, which calls for the development of novel therapeutic agents and innovative drug delivery strategies. Nanodrug (ND) combining multiple drugs with distinct modes of action holes the potential to circumvent these challenges, while the introduction of photothermal therapy (PTT) can give further significantly enhanced efficacy in cancer therapy. However, facile preparation of ND which contains dual drugs and photothermal capability with effective cancer treatment ability has rarely been reported. Methods In this study, we selected curcumin (Cur) and doxorubicin (Dox) as two model drugs for the creation of a cocktail ND (Cur-Dox ND). We utilized polyvinylpyrrolidone (PVP) as a stabilizer and regulator to prepare Cur-Dox ND in a straightforward one-pot method. Results The size of the resulting Cur-Dox ND can be easily adjusted by tuning the charged ratios. It was noted that both loaded drugs in Cur-Dox ND can realize their functions in the same target cell. Especially, the P-glycoprotein inhibition effect of Cur can synergistically cooperate with Dox, leading to enhanced inhibition of 4T1 cancer cells. Furthermore, Cur-Dox ND exhibited pH-responsive dissociation of loaded drugs and a robust photothermal translation capacity to realize multifunctional combat of cancer for photothermal enhanced anticancer performance. We further demonstrated that this effect can also be realized in 3D multicellular model, which possibly attributed to its superior drug penetration as well as photothermal-enhanced cellular uptake and drug release. Conclusion In summary, Cur-Dox ND might be a promising ND for better cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Wang,

Pan,

Chen

et al. 2024

IJN

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“…6,7 Particularly, introducing electron-donating nitrogen substituents at the bay positions has the potential to induce a significant red-shift in absorption and augment photothermal conversion efficiency, thus propelling PDIs as potential candidates for PTAs. [8][9][10] Nevertheless, the maximum absorption wavelength of these PDIs remains below 700 nm, restricting the penetration depth of phototherapy. 11,12 Although extending π-conjugation might facilitate red-shifted absorption, this strategy often results in poor molecular solubility.…”

mentioning

confidence: 99%

Regulating steric hindrances of perylenediimide to construct NIR photothermal J-aggregates with a large red-shift

Zhou,

Chen,

et al. 2023

Nanoscale

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Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics

Abstract: Phototheranostics that integrate diagnosis and treatment modalities have great promise in personalized cancer therapy. However, the “always on” characteristics often lead to suboptimal imaging quality and severe side effect. Herein,...

Cited by 2 publications

References 51 publications

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Polyvinylpyrrolidone Assisted One-Pot Synthesis of Size-Tunable Cocktail Nanodrug for Multifunctional Combat of Cancer

Regulating steric hindrances of perylenediimide to construct NIR photothermal J-aggregates with a large red-shift

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