Tumor microcirculation and its significance in therapy: possible role of omega-3 fatty acids as rheological modifiers

Baronzio, Gian Franco; Galante, F.; Gramaglia, Alberto; Barlocco, A.; Grandi, Samuele; Freitas, Isabel

doi:10.1016/s0306-9877(98)90204-3

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…42 Given the uneven presence of nutrients and impaired oxygenation in tumour microenvironment, the survival and invasiveness of tumour cells may rely on the modulation of anaerobic metabolism and of pentose phosphate pathways producing the NADPH needed for anabolic reductive biosynthesis and antioxidant defence. [43][44][45] The consequent decrease in the NAD(P)H bound fraction, due to the fewer binding sites engaged in pentose phosphate pathways and glycolytic metabolism, accounts for the weakening and shifting of the AF signal towards longer wavelengths. [46][47][48] Similar AF changes can reveal alterations in liver energy status and energy production machinery, depending on alterations in nutrients and oxygen supply, and metabolic disorders.…”

Section: Endog Enous Fluorophore Smentioning

confidence: 99%

Autofluorescence‐based optical biopsy: An effective diagnostic tool in hepatology

Croce

Ferrigno

Bottiroli

et al. 2018

Liver International

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Autofluorescence emission of liver tissue depends on the presence of endogenous biomolecules able to fluoresce under suitable light excitation. Overall autofluorescence emission contains much information of diagnostic value because it is the sum of individual autofluorescence contributions from fluorophores involved in metabolism, for example, NAD(P)H, flavins, lipofuscins, retinoids, porphyrins, bilirubin and lipids, or in structural architecture, for example, fibrous proteins, in close relationship with normal, altered or diseased conditions of the liver. Since the 1950s, hepatocytes and liver have been historical models to study NAD(P)H and flavins as in situ, real-time autofluorescence biomarkers of energy metabolism and redox state. Later investigations designed to monitor organ responses to ischaemia/reperfusion were able to predict the risk of dysfunction in surgery and transplantation or support the development of procedures to ameliorate the liver outcome. Subsequently, fluorescent fatty acids, lipofuscin-like lipopigments and collagen were characterized as optical biomarkers of liver steatosis, oxidative stress damage, fibrosis and disease progression. Currently, serum AF is being investigated to improve non-invasive optical diagnosis of liver disease. Validation of endogenous fluorophores and in situ discrimination of cancerous from non-cancerous tissue belong to the few studies on liver in human subjects. These reports along with other optical techniques and the huge work performed on animal models suggest many optically based applications in hepatology. Optical diagnosis is currently offering beneficial outcomes in clinical fields ranging from the respiratory and gastrointestinal tracts, to dermatology and ophthalmology. Accordingly, this review aims to promote an effective bench to bedside transfer in hepatology.

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Section: Endog Enous Fluorophore Smentioning

confidence: 99%

Autofluorescence‐based optical biopsy: An effective diagnostic tool in hepatology

Croce

Ferrigno

Bottiroli

et al. 2018

Liver International

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“…Bougnoux et al 126 noted a positive correlation between DHA level in breast adipose tissue of breast cancer patients and response to chemotherapy. An improved response to radiation (survival time) and a reduction of late radionecrosis were observed in patients receiving a mixture of ω‐3 PUFAs and unspecified bioflavonoids 127 …”

Section: Potential Nutrient Candidates For Modulating Gi Toxicity Relmentioning

confidence: 99%

Nutrition Modulation of Gastrointestinal Toxicity Related to Cancer Chemotherapy

Xue

Sawyer

Wischmeyer

et al. 2011

J Parenter Enteral Nutr

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Chemotherapy-induced gut toxicity is a major dose-limiting toxicity for many anticancer drugs. Gastrointestinal (GI) complications compromise the efficacy of chemotherapy, promote overall malnutrition, aggravate cancer cachexia, and may contribute to worsened prognosis. The GI tract is an attractive target for nutrition modulation, owing to its direct exposure to the diet, participation in uptake and metabolism of nutrients, high rate of cell turnover, and plasticity to nutrition stimuli. Glutamine, ω-3 polyunsaturated fatty acids, and probiotics/prebiotics are therapeutic factors that potentially modulate GI toxicity related to cancer treatments. Preclinical and clinical evidence are reviewed to critically define plausible benefits of these factors and their potential development into adjuncts to cancer chemotherapy. Mechanisms underlying the action of these nutrients are being unraveled in the laboratory. Optimal strategies to translate these findings into clinical care still remain to be elucidated. Key questions that remain to be answered include the following: which nutrient or combination of nutrients is selected for which patient and chemotherapy regimen? What mechanisms are responsible for modulation, and how are nutrient(s) administered in a clinically optimal manner? Research exploring interactions between different nutrients in GI protection is ongoing and demands further understanding. How nutrition preparations given to chemotherapy-treated patients are formulated in terms of component selection and dose optimization should be carefully studied and justified.

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“…The relationship between these parameters can be expressed by Starling's law. [33][34][35][36] (EQ.1) Fluid filtration = LpS [(P cap -P if ) -s( capif )] LpS = (␦ hydraulic pressure -␦ oncotic pressure)…”

Section: Tif Formation and Capillary Fluid Hemodynamicsmentioning

confidence: 99%

“…Normally, fibrinogen binds to activated PLTs, forming interplatelet bridges that restore the structural integrity of injured blood vessels. 34,50 Decreased blood flow permits an increased interaction among the various blood cellular components. PLTs, RBCs, and WBCs come into contact and favor an increased number of organized thrombi.…”

Section: Hemorheological Effect Of Tifmentioning

confidence: 99%

“…The acidic pH has been shown to decrease RBC deformability, and this permits an augmented intravascular aggregation. 12,33,34 Thrombogenic Effects of Biochemical Factors Produced by Hypoxia Endothelial response to hypoxia is of great importance because it primes the vasculature for inflammatory response. 5,52 The first interaction is between tumor and endothelium, and the second is between endothelium and circulating blood cells.…”

Section: Hemorheological Effect Of Tifmentioning

confidence: 99%

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Tumor Microenvironment and Hemorheological Abnormalities

Baronzio

Freitas

Kwaan

2003

Semin Thromb Hemost

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This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

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Tumor microcirculation and its significance in therapy: possible role of omega-3 fatty acids as rheological modifiers

Cited by 10 publications

References 40 publications

Autofluorescence‐based optical biopsy: An effective diagnostic tool in hepatology

Autofluorescence‐based optical biopsy: An effective diagnostic tool in hepatology

Nutrition Modulation of Gastrointestinal Toxicity Related to Cancer Chemotherapy

Tumor Microenvironment and Hemorheological Abnormalities

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