Tumor Markers CA 125 and CA 19–9 in Cord Blood and During Infancy: Developmental Changes and Use in Pediatric Germ Cell Tumors

Lahdenne, Pekka; Pitkänen, Sari; Rajantie, Jukka; Kuusela, Pentti; Ma, Siimes; Lanning, Marjatta; Heikinheimo, Markku

doi:10.1203/00006450-199511000-00026

Cited by 24 publications

(19 citation statements)

References 23 publications

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“…In agreement with our data, similar trends have been previously demonstrated for AFP, proGRP, and CA19-9 (7,9,18 ). Reference intervals were also previously established for both AFP and CA19-9.…”

Section: Discussionsupporting

confidence: 81%

“…Regarding CA19-9, the upper limit of the 0-to Ͻ1-year reference interval established in the current study (64 U/mL) was vastly . This may be due, in part, to the fact that Lahdenne et al used an RIA method and reagents (including antibodies) distinct from the ones used in the present study (7 ). Surprisingly, CA125 and CA15-3 showed a distinct pattern of expression compared to the first group of analytes (Fig.…”

Section: Discussioncontrasting

confidence: 43%

“…This pattern is likely explained by the fact that many of these analytes are expressed during fetal development and/or play an important role in early postnatal development (17)(18)(19). It is also possible that these analytes are found in higher concentrations in the serum of neonates due to immature hepatic function (7 ). That is, if the liver processes these proteins, the high serum concentrations observed here may be the result of inefficiency in immature neonatal livers.…”

Section: Discussionmentioning

confidence: 74%

“…Again, although the expression patterns were similar, the established values differed greatly from those of Lahdenne et al (7 ), who used an RIA method and reagents/antibodies distinct from those used in the present study. Whereas the upper limit of the 0-to Ͻ4-month reference interval established in the current study was 22 U/mL, the upper limit of the 95th percentile CI established by Lahdenne et al for the 0.1-to 0.5-year age range was 45 U/L (7 ).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, tumor markers such as squamous cell carcinoma antigen (SCC) 4 may now play an important role in pediatric as well as adult cancers. One final motive for studying these markers in the pediatric population is that there is early evidence that application of tumor markers such as cancer antigen 19-9 (CA19-9), CA125, carcinoembryonic antigen (CEA), and ␣-fetoprotein (AFP) has value in various types of pediatric cancers, including yolk sac tumors and teratomas (3,7 ).…”

mentioning

confidence: 99%

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Pediatric Population Reference Value Distributions for Cancer Biomarkers and Covariate-Stratified Reference Intervals in the CALIPER Cohort

et al. 2014

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BACKGROUND Cancer biomarkers are commonly used in pediatrics to monitor cancer progression, recurrence, and prognosis, but pediatric reference value distributions have not been well established for these markers. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) sought to develop a pediatric database of covariate-stratified reference value distributions for 11 key circulating tumor markers, including those used in assessment of patients with childhood or adult cancers. METHODS Healthy community children from birth to 18 years of age were recruited to participate in the CALIPER project with informed parental consent. We analyzed serum samples from 400–700 children (depending on the analyte in question) on the Abbott Architect ci4100 and established reference intervals for α-fetoprotein (AFP), antithyroglobulin (anti-Tg), human epididymis protein 4 (HE4), cancer antigen 125 (CA125), CA15-3, CA19-9, progastrin-releasing peptide (proGRP), carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC), and total and free prostate specific antigen (PSA) according to CLSI C28-A3 statistical guidelines. RESULTS We observed significant fluctuations in biomarker concentrations by age and/or sex in 10 of 11 biomarkers investigated. Age partitioning was required for CA153, CA125, CA19-9, CEA, SCC, proGRP, total and free PSA, HE4, and AFP, whereas sex partitioning was also required for CA125, CA19-9, and total and free PSA. CONCLUSIONS This CALIPER study established a database of childhood reference intervals for 11 tumor biomarkers and revealed dramatic fluctuations in tumor marker concentrations between boys and girls and throughout childhood. In addition, important differences between the adult and pediatric population were observed, further highlighting the need for pediatric-specific reference intervals.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Pediatric Population Reference Value Distributions for Cancer Biomarkers and Covariate-Stratified Reference Intervals in the CALIPER Cohort

et al. 2014

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Reference intervals of carbohydrate antigen 19‐9 in the apparently healthy adult population

Zhang

Bai

2018

Clinical Laboratory Analysis

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Diverse monoclonal antibodies against the CA 19‐9 antigen show variation in binding specificity with consequences for clinical interpretation

et al. 2012

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The CA 19-9 antigen is currently the best individual marker for the detection of pancreatic cancer. In order to optimize the CA 19-9 assay and to develop approaches to further improve cancer detection, it is important to understand the specificity differences between CA 19-9 antibodies and the consequential affect on biomarker performance. Antibody arrays enabled multiplexed comparisons between five different CA 19-9 antibodies used in the analysis of plasma samples from pancreatic cancer patients and controls. Major differences were observed between antibodies in their detection of particular patient samples. Glycan array analysis revealed that certain antibodies were highly specific for the canonical CA 19-9 epitope, sialyl-Lewis A, while others bound sialyl-Lewis A in addition to a related structure called sialyl-Lewis C and modification with Nue5Gc. In a much larger patient cohort we confirmed the binding of Sialyl-Lewis C glycan by one of the antibodies and showed that the broader specificity led to the detection of an increased number of cancer patients without increasing detection of pancreatitis patient samples. This work demonstrates that variation between antibody specificity for cancer-associated glycans can have significant implications for biomarker performance and highlights the value of characterizing and detecting the range of glycan structures that are elevated in cancer.

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Tumor Markers CA 125 and CA 19–9 in Cord Blood and During Infancy: Developmental Changes and Use in Pediatric Germ Cell Tumors

Cited by 24 publications

References 23 publications

Pediatric Population Reference Value Distributions for Cancer Biomarkers and Covariate-Stratified Reference Intervals in the CALIPER Cohort

Pediatric Population Reference Value Distributions for Cancer Biomarkers and Covariate-Stratified Reference Intervals in the CALIPER Cohort

Reference intervals of carbohydrate antigen 19‐9 in the apparently healthy adult population

Diverse monoclonal antibodies against the CA 19‐9 antigen show variation in binding specificity with consequences for clinical interpretation

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