Tumor Lysis Syndrome in Small Cell Lung Cancer: A Case Report and Review of the Literature

Jallad, Bassel; Hamdi, Tamim; Latta, Shadi; Alhosaini, Mohamad; Kheir, Fayez; Iroegbu, Nkemakolam

doi:10.1159/000324791

Cited by 19 publications

(19 citation statements)

References 13 publications

(12 reference statements)

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“…30 Most of the cases were attributable to chemotherapy, except two cases of spontaneous TLS. 28,29 Padhi and Singh incorrectly mentioned that their case was the first reported case of spontaneous TLS among patients with SCLC. 29 Spontaneous TLS was first officially reported by a group from our institution in 2011.…”

Section: Tumor Lysis Syndrome In Patients With Small Cell Lung Cancermentioning

confidence: 99%

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Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

et al. 2014

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Tumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. TLS is especially common in patients with hematological malignancies with rapid cellular turnover rates such as acute lymphocytic leukemia and Burkitt lymphoma, but is very rare in patients with solid tumors. Nevertheless, there are multiple reports in the literature on the occurrence of TLS in patients with solid tumors. In this review article, we summarize the current data on the occurrence of TLS in patients with solid tumors. We propose an algorithm of risk stratification and prevention of TLS in patients with solid cancers.

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Section: Tumor Lysis Syndrome In Patients With Small Cell Lung Cancermentioning

confidence: 99%

“…29 Spontaneous TLS was first officially reported by a group from our institution in 2011. 28 It is important to mention that most of the patients with SCLC who developed TLS had baseline elevation of LDH and other biochemical variables such as uric acid, potassium, creatinine and phosphorus.…”

Section: Tumor Lysis Syndrome In Patients With Small Cell Lung Cancermentioning

confidence: 99%

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

et al. 2014

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“…To the best of our knowledge, there were only three previous case reports that have described spontaneous TLS in SCLC, ours being the fourth case [5-7]. In the first two cases, both patients were found to have a significant tumor burden and expired shortly after diagnosis [5-6].…”

Section: Discussionmentioning

confidence: 86%

Spontaneous Tumor Lysis Syndrome in Small Cell Lung Cancer

Kanchustambham

Saladi

Patolia

et al. 2017

Cureus

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Tumor lysis syndrome (TLS) is a life-threatening oncologic complication caused by the lysis of a vast number of malignant cells resulting in metabolic derangements and organ dysfunction. TLS can occur spontaneously before initiation of any therapies often referred to as spontaneous tumor lysis syndrome (STLS), or shortly after the induction of chemotherapy, radiotherapy, or cytolytic antibody therapy. TLS is vastly seen in patients with hematological malignancies with high rapid cell turnover rates such as Burkitt lymphoma, acute myelogenous leukemia, and acute lymphocytic leukemia, and is rarely observed in solid tumors. However, TLS can occur in solid tumors, and there are multiple reports in the literature on the occurrence of TLS in various solid tumors. In this article, we report a case of STLS in small cell lung cancer followed by a brief review of the occurrence of TLS and STLS in small cell lung cancer.

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“…TLS usually occurs after starting cytotoxic medications and most commonly after induction chemotherapy in hematologic malignancies. However, spontaneous TLS in solid tumors, without the presence of precipitating chemotherapy, has rarely been described [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Rare Case of Spontaneous Tumor Lysis Syndrome (TLS) in a Patient with Germ Cell Tumor (GCT): Literature Review and Approach to Management

Mansour¹,

Brill²,

Gourdin³

2017

MOJCR

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Tumor Lysis Syndrome (TLS) is an oncologic emergency caused by destruction of malignant cells and release of intracellular components into the blood stream leading to numerous electrolyte abnormalities. Spontaneous TLS in solid tumors, without the presence of precipitating chemotherapy, has rarely been described. Germ cells tumors are the most common malignancy among men age 15-35 years of age. Due to the dramatic sensitivity of germ cell tumors to platinum based chemotherapy, systemic treatment in combination with surgical resection lead to cure rates ranging from 50%-90%. In a patient with spontaneous TLS, prior to initiation of chemotherapy, careful consideration of the treatment regimen is required. Although there are potential adverse effects of chemotherapy in any patient, these side effects may be further exacerbated in patients with significant co-morbidities. We will review a case of metastatic germ cell cancer presenting with spontaneous TLS and discuss implications for management in the acute setting.

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Tumor Lysis Syndrome in Small Cell Lung Cancer: A Case Report and Review of the Literature

Cited by 19 publications

References 13 publications

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

Tumor Lysis Syndrome in Solid Tumors: An up to Date Review of the Literature

Spontaneous Tumor Lysis Syndrome in Small Cell Lung Cancer

Rare Case of Spontaneous Tumor Lysis Syndrome (TLS) in a Patient with Germ Cell Tumor (GCT): Literature Review and Approach to Management

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