Tumor-localizing radionuclides in heterotransplanted human tumors in nude mice

Yeh, Samuel J.; Helson, Lawrence; Grando, Robert

doi:10.1016/0047-0740(79)90033-0

Cited by 5 publications

(1 citation statement)

References 3 publications

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“…One would expect a similar mechanism of uptake, and laboratory studies have shown that both 57 Co-BLM and 14 C-bleomycin are adsorbed to the cell membrane of tumour cells (4,8). It is shown that human tumours can be detected by 5 7 C O -B L M also when they are transplanted to nude mice (17). This will solve the problem associated with the use of high activity levels for microautoradiographic studies of human tumours.…”

Section: Discussionmentioning

confidence: 90%

The Place of 57Co-Bleomycin in the Evaluation of Tumours

Frederiksen¹,

Rasmussen²,

Flindt-Egebak³

et al. 1983

Nuklearmedizin

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162 patients were investigated by 57Co-bleomycin scintigraphy. 62 of these patients were also studied with 67Ga. 142 were suspected for malignant neoplastic disease, 20 for a focal inflammatory process. Good visualization with 57Co-bleomycin was obtained in 75% of malignant tumours and in 66% with 67Ga. Most of the patients were studied for abdominal disease and in this region 57Co-bleomycin was found to be qualitatively superior to 67Ga. The principal advantage of 57Co-bleomycin is a very low tissue background specially concerning the bowel. Neither 57Co-bleomycin nor 67Ga are tumour-specific. Both radiopharmaceuticals are taken up by inflammatory processes. This is a disadvantage in tumour diagnostics but the radionuclides can be useful for localizing inflammatory foci. The possibilities of studying the localisation of radionuclides at the cellular level will be discussed.

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Section: Discussionmentioning

confidence: 90%

The Place of 57Co-Bleomycin in the Evaluation of Tumours

Frederiksen¹,

Rasmussen²,

Flindt-Egebak³

et al. 1983

Nuklearmedizin

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Small Animal Oncological Models for Screening Diagnostic Radiotracers

Wiebe¹

1983

Animal Models in Radiotracer Design

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Tumor localization of alpha-aminoisobutyric acid (AIB) in human melanoma heterotransplants

Conti

Sordillo

et al. 1985

Eur J Nucl Med

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The nude mouse bearing a human tumor heterotransplant is a useful model for studying the tumor localization of radiolabeled compounds. The biological tissue distribution of carbon 14-labeled alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid, was determined in nude mice bearing human malignant melanoma heterotransplants in order to investigate the feasibility of using carbon 11 (t 1/2, 20.4 min)-labeled AIB for the visualization of human melanoma in vivo with positron emission tomography (PET). Our laboratory has previously demonstrated the use of 11C-labeled AIB as a tumor-imaging agent in a number of animal tumor models. The mean relative concentration of 14C-labeled AIB in tumor tissue at 45 min was 1.95 in this melanoma model. Tumor/blood and tumor/muscle ratios at 45 min postinjection were 5.42 and 12.2, respectively. These values suggest that 11C-labeled AIB may be useful for the in vivo study of malignant melanoma in humans. Alpha-aminoisobutyric acid (AIB), a synthetic, nonmetabolized amino acid, is thought to be actively accumulated into viable cells primarily by the A-type, or "alanine-prefering", amino acid transport system. AIB has been labeled with the short-lived, positron-emitting radionuclide, carbon 11 (t 1/2, 20.4 min), using a modified Bucherer-Strecker synthesis for amino acids. 11C-labeled AIB has been used to visualize tumors in dogs bearing spontaneous cancers, such as adenocarcinoma, lymphosarcoma, and osteogenic sarcoma, by utilizing positron-emission tomography (PET) and high-energy gamma (HEG) scintigraphy at the Sloan-Kettering Institute.(ABSTRACT TRUNCATED AT 250 WORDS)

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Tumor-localizing radionuclides in heterotransplanted human tumors in nude mice

Cited by 5 publications

References 3 publications

The Place of 57Co-Bleomycin in the Evaluation of Tumours

The Place of 57Co-Bleomycin in the Evaluation of Tumours

Small Animal Oncological Models for Screening Diagnostic Radiotracers

Tumor localization of alpha-aminoisobutyric acid (AIB) in human melanoma heterotransplants

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