Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models

Sheen, Allison; Agarwal, Yash; Cheah, Keith M.; Cowles, Sarah C.; Stinson, Jordan A.; Palmeri, Joseph R.; Sikes, Hadley D.; Wittrup, K. Dane

doi:10.1016/j.redox.2023.102766

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…CAT enzyme is a prominent oxidoreductase in vivo , playing a crucial role in scavenging ROS, safeguarding cell membranes, and impeding tumor progression. − CAT-like nanozymes are a class of nanomaterials exhibiting catalytic activity similar to that of CAT, enabling the decomposition of H 2 O 2 into molecular water (H 2 O) and O 2 according to the equation 2H 2 O 2 → 2H 2 O + O 2 (g) . The development of CAT-like nanozymes dates back to 2007, and since then, numerous reports have highlighted their potential for the treatment of disease .…”

Section: Catalytic Mechanismsmentioning

confidence: 99%

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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Cancer, as one of the leading causes of death worldwide, drives the advancement of cutting-edge technologies for cancer treatment. Transition-metal-based nanozymes emerge as promising therapeutic nanodrugs that provide a reference for cancer therapy. In this review, we present recent breakthrough nanozymes for cancer treatment. First, we comprehensively outline the preparation strategies involved in creating transition-metal-based nanozymes, including hydrothermal method, solvothermal method, chemical reduction method, biomimetic mineralization method, and sol−gel method. Subsequently, we elucidate the catalytic mechanisms (catalase (CAT)-like activities), peroxidase (POD)-like activities), oxidase (OXD)-like activities) and superoxide dismutase (SOD)-like activities) of transition-metal-based nanozymes along with their activity regulation strategies such as morphology control, size manipulation, modulation, composition adjustment and surface modification under environmental stimulation. Furthermore, we elaborate on the diverse applications of transition-metal-based nanozymes in anticancer therapies encompassing radiotherapy (RT), chemodynamic therapy (CDT), photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), immunotherapy, and synergistic therapy. Finally, the challenges faced by transition-metal-based nanozymes are discussed alongside future research directions. The purpose of this review is to offer scientific guidance that will enhance the clinical applications of nanozymes based on transition metals.

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Section: Catalytic Mechanismsmentioning

confidence: 99%

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Fu,

Wei,

Wang

2024

ACS Nano

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“…Catalase (CAT) is one of the key enzymes of the biological defense system, acting as an enzymatic scavenger in all living organisms to eliminate oxygen radicals [ 10 ]. CAT catalyzes the decomposition of H 2 O 2 to H 2 O and O 2 in both eukaryotes and prokaryotes.…”

Section: Introductionmentioning

confidence: 99%

Degradation Mechanism of Aflatoxin M1 by Recombinant Catalase from Bacillus pumilusE-1-1-1: Food Applications in Milk and Beer

Liu,

Zhao,

Wang

et al. 2024

Foods

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A bacteria capable of degrading aflatoxin M1 (AFM1) was isolated from African elephant manure. It was identified as Bacillus pumilus by 16s rDNA sequencing and named B. pumilusE-1-1-1. Compared with physical and chemical methods, biological methods have attracted much attention due to their advantages, such as thorough detoxification, high specificity, and environmental friendliness. This work aimed to study the effects of a recombinant catalase (rCAT) from B. pumilusE-1-1-1 on the degradation of AFM1 in pattern solution. The degradation mechanism was further explored and applied to milk and beer. Kinetic Momentum and Virtual Machine Maximum values for rCAT toward AFM1 were 4.1 μg/mL and 2.5 μg/mL/min, respectively. The rCAT-mediated AFM1 degradation product was identified as C15H14O3. Molecular docking simulations suggested that hydrogen and pi bonds played major roles in the steadiness of AFM1–rCAT. In other work, compared with identical density of AFM1, survival rates of Hep-G2 cells incubated with catalase-produced AFM1 degradation products increased by about 3 times. In addition, degradation rates in lager beer and milk were 31.3% and 47.2%, respectively. Therefore, CAT may be a prospective substitute to decrease AFM1 contamination in pattern solution, milk, and beer, thereby minimizing its influence on human health.

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Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy

Liu,

Zhang

et al. 2024

Acta Biomaterialia

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Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models

Cited by 5 publications

References 46 publications

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Transition-Metal-Based Nanozymes: Synthesis, Mechanisms of Therapeutic Action, and Applications in Cancer Treatment

Degradation Mechanism of Aflatoxin M1 by Recombinant Catalase from Bacillus pumilusE-1-1-1: Food Applications in Milk and Beer

Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy

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