Tumor-like Lesions of the Hepatobiliary Tract: Granulomatous Masses in Syphilis, Brucellosis, and Cat-Scratch Disease

Zimmermann, Arthur

doi:10.1007/978-3-319-26587-2_129-1

Cited by 1 publication

(1 citation statement)

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“…This vasculitis can affect the small blood vessels within the liver, leading to impaired blood flow and potentially causing areas of ischemia (lack of blood supply). Ischemic liver tissue can become necrotic, further contributing to liver dysfunction 14 Granulomatous reaction: Treponema pallidum infection can trigger the formation of granulomas in the liver tissue (Fig.…”

Section: Pathophysiologymentioning

confidence: 99%

“Syphilitic Hepatitis”

Goyal,

Dhaliwal,

Agrawal

2024

Journal of Clinical Gastroenterology

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Syphilitic hepatitis is a very rare presentation of syphilis infection, characterized by inflammation of the liver due to the invasion of hepatic tissue by the bacterium Treponema pallidum. This review article provides an in-depth analysis of the existing body of information pertaining to syphilitic hepatitis. The article primarily concentrates on key aspects such as the epidemiology, clinical manifestations, diagnostic methods, and therapeutic approaches associated with this condition. Despite its rarity, awareness of syphilitic hepatitis is vital for accurate diagnosis and appropriate intervention. The clinical presentations frequently exhibit similarities with many liver illnesses, hence presenting difficulties in making an accurate diagnosis. Common symptoms include fatigue, stomach pain, and jaundice. Diagnostic procedures encompass the use of serological assays, including rapid plasma reagin (RPR) and fluorescent treponemal antibody absorption (FTA-ABS), in conjunction with imaging modalities to evaluate hepatic engagement. The primary therapeutic approach is the prompt initiation of antibiotic therapy, with a particular emphasis on penicillin, to eradicate the causative bacterial infection and facilitate the restoration of liver function. Failure to swiftly manage this condition may result in substantial morbidity. In summary, syphilitic hepatitis is a very uncommon but medically relevant manifestation of syphilis infection. The significance of increased clinical suspicion, precise diagnostic techniques, and prompt antibiotic administration is emphasized in this review since these are crucial in reducing the potentially severe outcomes associated with this illness.

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Section: Pathophysiologymentioning

confidence: 99%