Tumor laterocervical de cuello: tiroides ectópico vs. metástasis de carcinoma tiroideo diferenciado

Fuentes, M. Nieves Sánchez; Bobadilla, José María Miguelena; Franco, María Carmen Casamayor; Domı́nguez, J.; Rascón, Miguel Ángel Dobón

doi:10.1016/j.ciresp.2013.10.007

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…Tumor size is a critical prognostic feature of cervical LNM, 19 , 22 and it is significantly associated with LNM in patients with DTC. According to our data, adverse clinical features (including male sex and white race) and disease aggressiveness (including the occurrence of gross ETE and distant metastasis) became more prevalent as the tumor size increased, which greatly explains the association between tumor size and LNM.…”

Section: Discussionmentioning

confidence: 99%

Tumor size interpretation for predicting cervical lymph node metastasis using a differentiated thyroid cancer risk model

Shi

Yang

et al. 2016

OTT

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Lymph node metastasis (LNM) is common in differentiated thyroid cancer (DTC), but management of clinically negative DTC is controversial. This study evaluated primary tumor size as a predictor of LNM. Multivariate logistic regression analysis was used for DTC patients who were treated with surgery between 2002 and 2012 in the Surveillance, Epidemiology, and End Results (SEER) database, to determine the association of tumor size at 10 mm increments with LNM. A predictive model was then developed to estimate the risk of LNM in DTC, using tumor size and other clinicopathological characteristics identified from the multivariate analysis. We identified 80,565 eligible patients with DTC in the SEER database. Final histology confirmed 9,896 (12.3%) cases affected with N1a disease and 8,194 (10.2%) cases with N1b disease. After the patients were classified into subgroups by tumor size, we found that the percentages of male sex, white race, follicular histology, gross extrathyroidal extension, lateral lymph node metastasis, and distant metastasis gradually increased with size. In multivariate analysis, tumor size was a significant independent prognostic factor for LNM; in particular, the odds ratio for lateral lymph node metastasis continued to increase by size relative to a 1–10 mm baseline. The coefficient for tumor size in the LNM predictive model waŝ0.20, indicating extra change in log(odds ratio) for LNM as 0.2 per unit increment in size relative to baseline. In conclusion, larger tumors are likely to have aggressive features and metastasize to a cervical compartment. Multistratification by size could provide more precise estimates of the likelihood of LNM before surgery.

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Section: Discussionmentioning

confidence: 99%

Tumor size interpretation for predicting cervical lymph node metastasis using a differentiated thyroid cancer risk model

Shi

Yang

et al. 2016

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“…Presently, multiple authors relate its origin to a metastatic deposit of well-differentiated thyroid carcinoma. The absence of lymph node tissue in the pathology study could be explained by the total replacement of the lymphoid tissue by the thyroid carcinoma [2] . However, the ectopic tissue can, in rare cases, include a primary thyroid carcinoma [1] , [4] .…”

Section: Discussionmentioning

confidence: 87%

“…The neural crest cells from the 4th and 5th lateral pharyngeal pouches contribute in the formation of parafollicular C cells. In the 3 following weeks, the primitive thyroid tissue descends from the foramen caecum, anterior to the hyoid bone and laryngeal cartilages, to reach its final pretracheal location, and then the diverticulum pathway retracts forming the thyroglossal duct which involutes later [1] , [2] , [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Abnormal descent of the thyroid gland leads to an ectopic thyroid mostly located in the midline area of its descending path described as lingual (90%), sublingual, thyroglossal or intralatyngotracheal. The occurrence of ectopic thyroid tissue in a non-midline site is extremely rare and can be found as lateral neck lymphatic nodules, on the pericardium, or on the cervical oesophagus and can be mistaken for neoplastic disease [1] , [2] , [5] . This ectopic entity may represent the only functional thyroid tissue in the body [4] .…”

Section: Discussionmentioning

confidence: 99%

“…Most ectopic thyroid tissues are located in the midline area corresponding to the embryological descending path of the gland. Lateral neck ectopic thyroid tissue remains a rare entity that can be affected by any lesion involving the gland [1] , [2] , [3] .…”

Section: Introductionmentioning

confidence: 99%

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Lateral neck ectopic thyroid carcinoma: Rare location for ectopic malignancy

Khadija

Oukessou

Rouadi

et al. 2021

International Journal of Surgery Case Reports

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Lateral neck ectopic thyroid tissue remains a rare entity that can be affected by any lesion involving the gland. The origin of lateral neck ectopic thyroid carcinomas still debated between a metastatic disease secondary to thyroid primary tumor and primary malignancy on the ectopic tissue. Anyway, it should indicate an exploration of the gland. We report the case of a 36 years old female with one year history of hyperthyroidism who was admitted for multinodular grade II goiter with a firm mass in the left level II of the lateral neck. The thyroid scintigraphy demonstrated multiple functioning nodules corresponding to toxic multinodular goiter; in addition to two cold hypofunctional nodules. The cervical ultrasound showed a voluminous multinodular goiter classified as EU TIRADS 5. The surgical procedure exposed a multinodular mass, lateral to the internal jugular vein, with the appearance and structure of the thyroid gland and no connection to it. The thyroid gland was exposed next through a collar incision. Each mass was dissected and removed individually. The histopathology examination of the thyroid gland found papillary carcinoma extracapsular extension. The pathology results of the other mass reported multiple colloid nodules with cystic component, papillary in appearance, with the same cancer proliferation, compatible with ectopic thyroid tissue with papillary carcinoma. No lymph node tissue was found. The patient was sent for complementary RAItherapy. We report a rare case of lateral neck ectopic thyroid papillary carcinoma that supplements and supports the lacking literature data concerning the management of this rare entity.

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Benign Ectopic Thyroid in the Lateral (Level II) Neck Compartment

Liu¹,

Berry²,

Desai³

et al. 2022

Cureus

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Ectopic thyroid most commonly presents in the midline and is typically associated with the absence of an orthotopic thyroid. Less commonly, ectopic thyroid can present in the lateral neck, typically with a coexisting orthotopic thyroid and abnormal pathology in either the ectopic or orthotopic thyroid tissue. This paper describes a rare case of a benign, ectopic thyroid in the lateral neck (level II) associated with a normal, benign orthotopic thyroid. This report illustrates clinical pearls for the management of this unusual entity.

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Tumor laterocervical de cuello: tiroides ectópico vs. metástasis de carcinoma tiroideo diferenciado

Cited by 3 publications

References 6 publications

Tumor size interpretation for predicting cervical lymph node metastasis using a differentiated thyroid cancer risk model

Tumor size interpretation for predicting cervical lymph node metastasis using a differentiated thyroid cancer risk model

Lateral neck ectopic thyroid carcinoma: Rare location for ectopic malignancy

Benign Ectopic Thyroid in the Lateral (Level II) Neck Compartment

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