Tumor Intrinsic Subtypes and Gene Expression Signatures in Early-Stage ERBB2/HER2-Positive Breast Cancer
Aranzazu Fernandez-Martinez,
Mattia Rediti,
Gong Tang
et al.
Abstract:ImportanceBiologic features may affect pathologic complete response (pCR) and event-free survival (EFS) after neoadjuvant chemotherapy plus ERBB2/HER2 blockade in ERBB2/HER2-positive early breast cancer (EBC).ObjectiveTo define the quantitative association between pCR and EFS by intrinsic subtype and by other gene expression signatures in a pooled analysis of 3 phase 3 trials: CALGB 40601, NeoALTTO, and NSABP B-41.Design, Setting, and ParticipantsIn this retrospective pooled analysis, 1289 patients with EBC re… Show more
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