Tumor inhibitors. XLIV. Isolation and characterization of hellebrigenin 3-acetate and hellebrigenin 3,5-diacetate, Bufadienolide tumor inhibitors from Bersama abyssinica

Antiviral activity against human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) of ethnobotanically selected Ethiopian medicinal plants

“…The different parts of B. abyssinica have previously been subjected to phytochemical and biological investigations. The fruits have yielded a series of bufadienolides with anti-tumour activity (Kupchan et al, 1969;Kupchan et al, 1971). The alcohol extract of the stem bark was reported to be devoid of anti-tumour activity although two bufadienolides together with sterols and a xanthone have been isolated from it (Bowen et al, 1985).…”

Antitumor Agents V: Cytotoxic Cardenolides from Cryptostegia grandiflora (Roxb.) R. Br.

“…Other cardenolides that are cytotoxic are known (17)(18)(19), and a parallel appears to exist between cytotoxicity towards KB cells, a heart action, and the inhibition of the ATPase enzymes of the active transport of potassium and scdium ions (20). Other cardenolides that are cytotoxic are known (17)(18)(19), and a parallel appears to exist between cytotoxicity towards KB cells, a heart action, and the inhibition of the ATPase enzymes of the active transport of potassium and scdium ions (20).…”

Review of Medicinal Uses, Phytochemistry, and Pharmacological Properties of Drimia Elata

“…The extract exhibited total Maroyi growth inhibition values of 1.1 µg/ml against ovarian (OVCAR-3), 1.4 µg/ml against central nervous system cancer, CNSC SF-539 and 1.4 µg/ml against non-small cell lung cancer, NSCLC A549/ATCC [81]. The documented anticancer activities may be attributed to bufadienolides as these compounds are known to have anticancer activities [62][63][64][65][66][67][68].…”

“…Van et al [61] argued that there is a danger of accidental poisoning or that people may be harmed if bulbs of D. elata are used indiscriminately as rubbing the bulb scales or leaves on bare skin produces a stinging and irritating effect and a skin rash is produced. However, bufadienolides are known to have a wide range of biological activities including anti-tumor, antiproliferative, and cytotoxic activities [62][63][64][65][66][67][68].…”