Tumor-infiltrating CD45RO+ memory cells are associated with a favorable prognosis breast cancer

Yajima, Reina; Yajima, Toshiki; Fujii, Takaaki; Yanagita, Yasuhiro; Fujisawa, Tomomi; Miyamoto, Takeshi; Tsutsumi, Soichi; Iijima, Misa; Kuwano, Hiroyuki

doi:10.1007/s12282-015-0622-y

Cited by 25 publications

(21 citation statements)

References 26 publications

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“…Additionally, in other studies, CD3 + and CD45RO + TILs were significantly correlated with clinico-pathological features [39,40]. However, in our study, no significant correlation was observed, except for CD3 + and lymph node metastasis, this may be further explored in a larger patient cohort.…”

Section: Discussioncontrasting

confidence: 62%

CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

Mohamed

Sarwath

Salih³

et al. 2016

transl med commun

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Background: Breast Cancer in the Middle East and North Africa region (MENA) occurs in a younger age group of patients and is more aggressive than in Europe and North America. Little is known about the presence of immune infiltration and clinico-pathologic correlates in patients from the MENA region. Immune infiltration of most solid tumors carries a prognostic role. Adaptive immune cells and cytotoxic T-cells, in particular, play a positive prognostic role in patients undergoing treatment for breast cancer. Therefore, our preliminary study was aimed to identify and quantify the presence of tumor infiltrating lymphocytes (TILs) (CD8 + , CD45RO

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Section: Discussioncontrasting

confidence: 62%

CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

Mohamed

Sarwath

Salih³

et al. 2016

transl med commun

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“…There is a general consensus that in the context of the antitumor immune response, the frequency of CD8 + lymphocytes and their memory T cell subsets correlates positively with smaller tumor size, lower disease stages, less lymph node involvement, and a generally better prognosis or survival in most types of cancer, e.g. breast carcinoma [14,[16][17][18][19][20][21][22]. CD8 + lymphocytes are assumed to mediate tumor rejection through the direct killing of transformed cells.…”

Section: Discussionmentioning

confidence: 99%

CD8-positive memory T cells in tumor-draining lymph nodes of patients with breast cancer

Vahidi

Bagheri²,

Ghaderi

et al. 2020

BMC Cancer

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Background: Human immunological memory is a hallmark of the adaptive immune system and plays an important role in the development of effective immune responses against tumors. In the present study, we aimed to determine the frequencies of CD8 + memory T cell subsets including T stem cell memory (TSCM) in tumor-draining lymph nodes of patients with breast cancer (BC). Methods: Mononuclear cells were obtained from axillary lymph nodes of 52 untreated patients with BC and stained for CD8, CCR7, CD45RO, CD95 markers to detect different subtypes of memory cells in the CD8 + lymphocyte population. Data were acquired on four-color flow cytometer and analyzed with CellQuest Pro software. Results: We observed that 47.65 ± 2.66% of CD8 + lymphocytes expressed the CD45RO, a marker for memory T cells. Statistical analysis showed that the total frequency of central memory T cells (TCM) and their subset with low CD45RO expression was significantly higher in tumor-involved nodes compared to tumor-free ones (P = 0.024 and P = 0.017, respectively). The level of CD95 expression (based on mean fluorescence intensity) on the surface of TCM, their CD45RO hi and CD45RO low subsets, and TSCM was higher in patients with stage II compared to those in stage I (P < 0.05). In addition, the percentage of naive CD8 + T cells was significantly lower in tumor-involved lymph nodes compared to tumor-free ones (P = 0.025). Conclusions: Our data collectively indicate no significant differences in the frequencies of CD8 + lymphocytes or their memory subsets in tumor-draining lymph nodes of patients with BC. However, the frequency of CD45 low TCM was higher in tumor-involved nodes. Along with a decrease in the frequency of naive T cells, the higher frequency of CD45 low TCM suggests that despite the immune reaction to provide a pool of effective memory cells, it is blocked in early-stage of memory cells' differentiation (CD45RO low), probably by tumor-derived suppressive factors. Identifying the molecular and cellular mechanisms behind this suppression can provide invaluable tools for adoptive T cell therapies in cancer.

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“…These studies indicate the anti-tumor effect of CD45RO + T cells. In addition, CD45RO + TILs are negatively correlated with tumor size, lymph nodes metastasis in breast cancer patients (27), associated with lesser advanced T stage and TNM stage in rectal cancer (28), and correlated with well differentiation and lower TNM stage in renal cell carcinoma (29). Consistent with previous studies, we found that CD45RO expression was increased in lung adenocarcinoma tissues compared to paired adjacent lung tissues, and CD45RO + TILs were negatively correlated with tumor size, lymph node metastasis and TNM stage in lung adenocarcinoma patients.…”

Section: Analysis Of Baseline Factors Affecting Osmentioning

confidence: 99%

Tumor-infiltrating CD45RO+ memory cells correlate with favorable prognosis in patients with lung adenocarcinoma

Zhong

2018

J. Thorac. Dis.

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Tumor-infiltrating CD45RO+ memory cells are associated with a favorable prognosis breast cancer

Cited by 25 publications

References 26 publications

CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

CD8+ tumor infiltrating lymphocytes strongly correlate with molecular subtype and clinico-pathological characteristics in breast cancer patients from Sudan

CD8-positive memory T cells in tumor-draining lymph nodes of patients with breast cancer

Tumor-infiltrating CD45RO+ memory cells correlate with favorable prognosis in patients with lung adenocarcinoma

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