Tumor-Infiltrating CD1a+ DCs and CD8+/FoxP3+ Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma Patients

Ni, Yanhong; Zhang, Xiao‐Xin; Lu, Zhanyi; Huang, Xiaofeng; Wang, Zhiyong; Yang, Yan; Dong, Yingchun; Yue, Jing; Song, Yuxian; Hou, Yayi; Hua, Zichun; Hu, Qingang

doi:10.1007/s12253-019-00701-5

Cited by 16 publications

(21 citation statements)

References 34 publications

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“…However, several other studies indicated that there is no such correlation with prognosis. One study even found a negative effect of CD8+ TIL on survival, but this did not reach statistical significance in multivariate analysis [28][29][30]. By contrast, as one of the paradoxically functional components of tumor-related immune system, FoxP3+…”

Section: Discussionmentioning

confidence: 99%

“…For patients with tonsillar cancer, a high CD8/Foxp3+ ratio positively correlated with DFS [40]. Ni et al had reported that increased CD8/FoxP3 ratios were associated with improved OS, DFS and tumor stage in tongue cancer but was not an independent prognostic factor in MVA [28]. Similar to these studies, this cohort demonstrated that high CD8/FoxP3 ratio correlated with favorable prognosis and CD8 expression, which further confirmed that CD8+ TIL is associated with good prognosis in HPSCC patients.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, CD4/CD8 ratio can potentially be used for the same purpose in squamous cell carcinoma of the cervix [42]. However, there were also instances in which CD4/CD8 ratio was not linked to clinical outcomes, and some researchers even reported that high CD4/CD8 ratio was associated with tumor recurrence and the absence of lymphovascular invasion [28,41,43,44]. The tendency for better clinical outcomes and progression in patients with high CD4/CD8 ratio is of note, despite the prognostic significance being limited to relatively few studies and insufficient for clinical use.…”

Section: Discussionmentioning

confidence: 99%

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The role of tumor infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in hypopharyngeal squamous cell carcinoma

Wang

Tian

Sun

et al. 2020

Preprint

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Background: Cancer cells induce the infiltration of various immune cells located or distributed in different sites and playing multiple roles, which have recently been proposed to predict clinical outcomes. We therefore studied the prognostic significance based on the presence of tumor infiltrating lymphocytes (TILs) and the ratios between different types of immune cells in hypopharyngeal squamous cell carcinoma (HPSCC).Methods: We retrospectively analysed 132 consecutive patients diagnosed with HPSCC in 2013-2017. Tumoral parenchyma were immunohistochemically counted manually for the number of CD8, CD4 and Foxp3. The ratios of CD8/Foxp3 and CD4/CD8 were calculated for each specimen, and analyzed with respect to patient clinicopathologic variables and prognosis. Results: HPSCC patients with high levels of TILs showed evidently correlations with well differentiated tumors (P < 0.05). Increased Foxp3+ TIL is also significantly associated with Stage and T stage (P =0.048 and P= 0.046, respectively). Kaplan-Meier analysis showed that high CD8 and FoxP3 infiltration correlated with favorable overall survival (OS, P = 0.019 and P = 0.001), disease-free survival (DFS, P = 0.045 and P = 0.028) and distant metastasis-free survival (DMFS, P = 0.034 and P = 0.009), respectively, but only FoxP3 displayed prognostic significance for DMFS in multivariate analysis (MVA). In lymphocyte ratios analysis, CD8/FoxP3 appeared to play a pivotal role, patients with high CD8/FoxP3 ratio had a superior 3-year DFS and DMFS compared with the low value of this parameter in both univariate analysis (UVA) and MVA (P = 0.015 and P=0.001). Meanwhile, high CD4/CD8 ratio had significantly better DFS and local relapse-free survival (LRFS) in UVA, and exhibited an independent prognostic factor for improved LRFS in MVA (P = 0.040).Conclusion: Although high TILs were determined to be prognostically significant in HPSCC, the ratios of these subsets may be more informative. Particularly, higher ratio of CD8/Foxp3 accurately predict prognosis for improved DFS and DMFS, and increment of CD4/CD8 ratio was an independent predictor for favorable LRFS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The role of tumor infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in hypopharyngeal squamous cell carcinoma

Wang

Tian

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…However, several other studies indicated that there is no such correlation with prognosis. One study even found a negative effect of CD8+ TILs on survival, but this did not reach statistical signi cance in multivariate analysis [28][29][30]. In contrast, as one of the paradoxically functional components of the tumour-related immune system, Foxp3+ TILs are considered to be the most speci c Treg marker involved in maintaining immune tolerance to the host.…”

Section: Discussionmentioning

confidence: 99%

“…For patients with tonsillar cancer, a high CD8/Foxp3+ ratio positively correlated with DFS [40]. Ni et al reported that increased CD8/Foxp3 ratios were associated with improved OS, DFS and tumour stage in tongue cancer but were not an independent prognostic factor in MVA [28]. Similar to these studies, this cohort demonstrated that a high CD8/Foxp3 ratio correlated with favourable prognosis and CD8 expression, which further con rmed that CD8+ TILs are associated with good prognosis in advanced HPSCC patients.…”

Section: Discussionmentioning

confidence: 99%

The presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in advanced hypopharyngeal squamous cell carcinoma

Wang

Tian

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background: Cancer cells induce the infiltration of various immune cells that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We therefore studied the prognostic significance of the presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different types of immune cells in hypopharyngeal squamous cell carcinoma (HPSCC). Methods: We retrospectively analysed 132 consecutive patients diagnosed with advanced HPSCC in 2013-2017. Tumoural parenchyma was immunohistochemically counted manually for the number of CD8, CD4 and Foxp3 cells. The ratios of CD8/Foxp3 and CD8/CD4 ratios were calculated for each specimen and analyzed with respect to patient clinicopathological variables and prognosis. Results: HPSCC patients with high levels of TILs showed evident correlations with well differentiated tumors (P < 0.05). Moreover, Foxp3+ TIL is also associated with overall staging group and T category (P =0.048 and P= 0.046, respectively). Kaplan-Meier analysis showed that high CD8 and FoxP3 infiltration correlated with favourable overall survival (OS, P = 0.019 and P = 0.001), disease-free survival (DFS, P = 0.045 and P = 0.028) and distant metastasis-free survival (DMFS, P = 0.034 and P = 0.009), respectively, but only Foxp3 displayed prognostic significance for DMFS in multivariate analysis (MVA). In the lymphocyte ratio analysis, CD8/Foxp3 appeared to play a pivotal role, and patients with a high CD8/Foxp3 ratio had a superior 3-year DFS and DMFS compared with those a low CD8/Foxp3 ratio in both univariate analysis (UVA) and MVA (P = 0.015 and P=0.011). A high CD8/CD4 ratio was associated with better DFS and local relapse-free survival (LRFS) in UVA, and was an independent prognostic factor for improved LRFS in MVA (P = 0.040).Conclusion: Although high TILs levels were determined to be prognostically significant in advanced HPSCC, the ratios of these subsets may be more informative. Particularly, a higher ratio of CD8/Foxp3 accurately predicts prognosis for improved DFS and DMFS, and an increased CD8/CD4 ratio is an independent predictor for favourable LRFS.

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Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors

Sun

Yuan

et al. 2021

Journal of Gastrointestinal Surgery

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Tumor-Infiltrating CD1a+ DCs and CD8+/FoxP3+ Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma Patients

Cited by 16 publications

References 34 publications

The role of tumor infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in hypopharyngeal squamous cell carcinoma

The role of tumor infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in hypopharyngeal squamous cell carcinoma

The presence of tumour-infiltrating lymphocytes (TILs) and the ratios between different subsets serve as prognostic factors in advanced hypopharyngeal squamous cell carcinoma

Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors

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