Tumor induction in hamsters inoculated with an avian adenovirus (CELO)

Mancini, L; Anderson, Jeffrey P.; Jasty, V.; Yates, Vance J.

doi:10.1007/bf01250198

Cited by 5 publications

(1 citation statement)

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“…Like a number of mammalian adenoviruses, CELO virus is capable of generating tumors when injected into baby hamsters (40,51,52,66). CELO virus is also capable of transforming some cell types in vitro (6,7).…”

Section: Discussionmentioning

confidence: 99%

The complete DNA sequence and genomic organization of the avian adenovirus CELO

Chiocca

Kurzbauer

Schaffner

et al. 1996

J Virol

200

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The complete DNA sequence of the avian adenovirus chicken embryo lethal orphan (CELO) virus (FAV-1) is reported here. The genome was found to be 43,804 bp in length, approximately 8 kb longer than those of the human subgenus C adenoviruses (Ad2 and Ad5). This length is supported by pulsed-field gel electrophoresis analysis of genomes isolated from several related FAV-1 isolates (Indiana C and OTE). The genes for major viral structural proteins (IIIa, penton base, hexon, pVI, and pVIII), as well as the 52,000-molecular-weight (52K) and 100K proteins and the early-region 2 genes and IVa2, are present in the expected locations in the genome. CELO virus encodes two fiber proteins and a different set of the DNA-packaging core proteins, which may be important in condensing the longer CELO virus genome. No pV or pIX genes are present. Most surprisingly, CELO virus possesses no identifiable E1, E3, and E4 regions. There is 5 kb at the left end of the CELO virus genome and 15 kb at the right end with no homology to Ad2. The sequences are rich in open reading frames, and it is likely that these encode functions that replace the missing E1, E3, and E4 functions.

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Section: Discussionmentioning

confidence: 99%